-
1
-
-
34548487159
-
Insomnia: Definition, prevalence, etiology, and consequences
-
Roth T. Insomnia: Definition, prevalence, etiology, and consequences. J Clin Sleep Med 2007;3(Suppl):S7-10.
-
(2007)
J Clin Sleep Med
, vol.3
, pp. S7-10
-
-
Roth, T.1
-
2
-
-
33644517260
-
Epidemiology of insomnia: Prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors
-
Morin CM, LeBlanc M, Daley M, Gregoire JP, Mérette C. Epidemiology of insomnia: Prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep Med 2006;7:123-30.
-
(2006)
Sleep Med
, vol.7
, pp. 123-130
-
-
Morin, C.M.1
Leblanc, M.2
Daley, M.3
Gregoire, J.P.4
Mérette, C.5
-
3
-
-
84883550757
-
Optimizing the pharmacologic treatment of insomnia: Current status and future horizons
-
Minkel J, Krystal AD. Optimizing the pharmacologic treatment of insomnia: Current status and future horizons. Sleep Med Clin 2013;8:333-50.
-
(2013)
Sleep Med Clin
, vol.8
, pp. 333-350
-
-
Minkel, J.1
Krystal, A.D.2
-
4
-
-
84867317521
-
-
[Last accessed on 2014 Sep 18]
-
FDA News Release: FDA Approves New Type of Sleep Drug. Available from: http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm 409950.htm. [Last accessed on 2014 Sep 18].
-
FDA News Release: FDA Approves New Type of Sleep Drug
-
-
-
5
-
-
77957095308
-
Expression of orexin receptors 1 (OX1R) and 2 (OX2R) in the porcine hypothalamus during the oestrous cycle
-
Kaminski T, Smolinska N, Nitkiewicz A, Przala J. Expression of orexin receptors 1 (OX1R) and 2 (OX2R) in the porcine hypothalamus during the oestrous cycle. J Physiol Pharmacol 2010;61:363-71.
-
(2010)
J Physiol Pharmacol
, vol.61
, pp. 363-371
-
-
Kaminski, T.1
Smolinska, N.2
Nitkiewicz, A.3
Przala, J.4
-
6
-
-
79951994324
-
Orexin receptors: Pharmacology and therapeutic opportunities
-
Scammell TE, Winrow CJ. Orexin receptors: Pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol 2011;51:243-66.
-
(2011)
Annu Rev Pharmacol Toxicol
, vol.51
, pp. 243-266
-
-
Scammell, T.E.1
Winrow, C.J.2
-
7
-
-
84904961158
-
Opportunities and perspectives for developing orexin receptor antagonists
-
Steiner MA, Winrow CJ. Opportunities and perspectives for developing orexin receptor antagonists. Front Neurosci 2014;8:158.
-
(2014)
Front Neurosci
, vol.8
, pp. 158
-
-
Steiner, M.A.1
Winrow, C.J.2
-
8
-
-
77954731181
-
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan- 1-yl] [5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl] methanone (MK-4305) for the treatment of insomnia
-
Cox CD, Breslin MJ, Whitman DB, Schreier JD, McGaughey GB, Bogusky MJ, et al. Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan- 1-yl] [5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl] methanone (MK-4305) for the treatment of insomnia. J Med Chem 2010;53:5320 - 32.
-
(2010)
J Med Chem
, vol.53
, pp. 5320-5332
-
-
Cox, C.D.1
Breslin, M.J.2
Whitman, D.B.3
Schreier, J.D.4
McGaughey, G.B.5
Bogusky, M.J.6
-
9
-
-
84928641288
-
-
[Last accessed on 2014 Sep 18]
-
Suvorexant Advisory Committee Meeting Briefing Document, NDA 204569. Available from: http://www.fda.gov/downloads/Advisory Committees/CommitteesMeetingMaterials/Drugs/Peripheraland Central Nervous System Drugs Advisory Committee/UCM352970.pdf. [Last accessed on 2014 Sep 18].
-
Suvorexant Advisory Committee Meeting Briefing Document, NDA 204569
-
-
-
10
-
-
84871323368
-
Orexin receptor antagonism for treatment of insomnia: A randomized clinical trial of suvorexant
-
Herring WJ, Snyder E, Budd K, Hutzelmann J, Snavely D, Liu K, et al. Orexin receptor antagonism for treatment of insomnia: A randomized clinical trial of suvorexant. Neurology 2012;79:2265-74.
-
(2012)
Neurology
, vol.79
, pp. 2265-2274
-
-
Herring, W.J.1
Snyder, E.2
Budd, K.3
Hutzelmann, J.4
Snavely, D.5
Liu, K.6
-
11
-
-
84873388862
-
Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men
-
Sun H, Kennedy WP, Wilbraham D, Lewis N, Calder N, Li X, et al. Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men. Sleep 2013;36:259-67.
-
(2013)
Sleep
, vol.36
, pp. 259-267
-
-
Sun, H.1
Kennedy, W.P.2
Wilbraham, D.3
Lewis, N.4
Calder, N.5
Li, X.6
-
12
-
-
84907923574
-
Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects
-
Ma J, Svetnik V, Snyder E, Lines C, Roth T, Herring WJ. Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects. Sleep 2014;37:1609-19.
-
(2014)
Sleep
, vol.37
, pp. 1609-1619
-
-
Ma, J.1
Svetnik, V.2
Snyder, E.3
Lines, C.4
Roth, T.5
Herring, W.J.6
-
13
-
-
84898546938
-
Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: A phase 3 randomised, double-blind, placebo-controlled trial
-
Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, et al. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: A phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol 2014;13:461-71.
-
(2014)
Lancet Neurol
, vol.13
, pp. 461-471
-
-
Michelson, D.1
Snyder, E.2
Paradis, E.3
Chengan-Liu, M.4
Snavely, D.B.5
Hutzelmann, J.6
-
14
-
-
84898044015
-
Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors
-
Callander GE, Olorunda M, Monna D, Schuepbach E, Langenegger D, Betschart C, et al. Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors. Front Neurosci 2013;7:230.
-
(2013)
Front Neurosci
, vol.7
, pp. 230
-
-
Callander, G.E.1
Olorunda, M.2
Monna, D.3
Schuepbach, E.4
Langenegger, D.5
Betschart, C.6
-
15
-
-
84907077800
-
Schedules of controlled substances: Placement of suvorexant into Schedule IV
-
Drug Enforcement Administration, Department of Justice
-
Drug Enforcement Administration, Department of Justice. Schedules of controlled substances: Placement of suvorexant into Schedule IV. Final rule. Fed Regist 2014;79:51243-7.
-
(2014)
Final Rule. Fed Regist
, vol.79
, pp. 51243-51247
-
-
-
16
-
-
84928644531
-
-
[Last accessed on 2014 Sep 18]
-
News: Actelion, Glaxo Stop Development of Insomnia Medicine. Available from: http://www.bloomberg.com/news/2011-01-28/actelion-glaxo-stop -development-of-insomnia-medicine-on-safety-concern.html. [Last accessed on 2014 Sep 18].
-
News: Actelion, Glaxo Stop Development of Insomnia Medicine
-
-
-
17
-
-
84897024986
-
Discovery of 5''- chloro-N-[(5,6-dimethoxypyridin-2-yl) methyl]-2,2':5',3''-terpyridine-3'- carboxamide (MK-1064): A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
-
Roecker AJ, Mercer SP, Schreier JD, Cox CD, Fraley ME, Steen JT, et al. Discovery of 5''- chloro-N-[(5,6-dimethoxypyridin-2-yl) methyl]-2,2':5',3''-terpyridine-3'- carboxamide (MK-1064): A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Chem Med Chem 2014;9:311-22.
-
(2014)
Chem Med Chem
, vol.9
, pp. 311-322
-
-
Roecker, A.J.1
Mercer, S.P.2
Schreier, J.D.3
Cox, C.D.4
Fraley, M.E.5
Steen, J.T.6
-
18
-
-
84898027536
-
Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice
-
Etori K, Saito YC, Tsujino N, Sakurai T. Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice. Front Neurosci 2014;8:8.
-
(2014)
Front Neurosci
, vol.8
, pp. 8
-
-
Etori, K.1
Saito, Y.C.2
Tsujino, N.3
Sakurai, T.4
-
19
-
-
84887991602
-
Orexin in sleep, addiction and more: Is the perfect insomnia drug at hand?
-
Hoyer D, Jacobson LH. Orexin in sleep, addiction and more: Is the perfect insomnia drug at hand? Neuropeptides 2013;47:477-88.
-
(2013)
Neuropeptides
, vol.47
, pp. 477-488
-
-
Hoyer, D.1
Jacobson, L.H.2
|