-
1
-
-
33846379526
-
Therapeutic resistance in lung cancer
-
COI: 1:CAS:528:DC%2BD28XhtValtbvF, PID: 17014393
-
Nadkar A, Pungaliya C, Drake K, Zajac E, Singhal SS, Awasthi S. Therapeutic resistance in lung cancer. Expert Opin Drug Metab Toxicol. 2006;2:753–77.
-
(2006)
Expert Opin Drug Metab Toxicol
, vol.2
, pp. 753-777
-
-
Nadkar, A.1
Pungaliya, C.2
Drake, K.3
Zajac, E.4
Singhal, S.S.5
Awasthi, S.6
-
2
-
-
1942520367
-
Nrf2 signaling in coordinated activation of antioxidant gene expression
-
COI: 1:CAS:528:DC%2BD2cXjsVelsL4%3D, PID: 15110384
-
Jaiswal AK. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med. 2004;36:1199–207.
-
(2004)
Free Radic Biol Med
, vol.36
, pp. 1199-1207
-
-
Jaiswal, A.K.1
-
3
-
-
79953236274
-
Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis
-
PID: 21295136
-
Stępkowski TM, Kruszewski MK. Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis. Free Radic Biol Med. 2011;50:1186–95.
-
(2011)
Free Radic Biol Med
, vol.50
, pp. 1186-1195
-
-
Stępkowski, T.M.1
Kruszewski, M.K.2
-
4
-
-
77958140054
-
The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer
-
COI: 1:CAS:528:DC%2BC3cXht12ltL%2FP, PID: 20486759
-
Zhang DD. The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer. Antioxid Redox Signal. 2010;13:1623–6.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 1623-1626
-
-
Zhang, D.D.1
-
5
-
-
33750885385
-
Dysfunctional KEAP1–NRF2 interaction in non-small-cell lung cancer
-
PID: 17020408
-
Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, et al. Dysfunctional KEAP1–NRF2 interaction in non-small-cell lung cancer. PLoS Med. 2006;3:e420.
-
(2006)
PLoS Med
, vol.3
, pp. e420
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
-
6
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
COI: 1:CAS:528:DC%2BD1cXislagtbo%3D, PID: 18316592
-
Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res. 2008;68:1303–9.
-
(2008)
Cancer Res
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
-
7
-
-
66149168685
-
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
-
COI: 1:CAS:528:DC%2BD1MXmtVKmu7k%3D, PID: 19417020
-
Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, et al. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res. 2009;15:3423–32.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3423-3432
-
-
Homma, S.1
Ishii, Y.2
Morishima, Y.3
Yamadori, T.4
Matsuno, Y.5
Haraguchi, N.6
-
8
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
COI: 1:CAS:528:DC%2BD28XislKqsLg%3D, PID: 16507366
-
Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell. 2006;21:689–700.
-
(2006)
Mol Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
Tong, K.I.2
Ohta, T.3
Nakamura, Y.4
Scharlock, M.5
Ohtsuji, M.6
-
9
-
-
77958129306
-
Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance
-
COI: 1:CAS:528:DC%2BC3cXht12ltL%2FN, PID: 20446773
-
Singh A, Bodas M, Wakabayashi N, Bunz F, Biswal S. Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid Redox Signal. 2010;13:1627–37.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 1627-1637
-
-
Singh, A.1
Bodas, M.2
Wakabayashi, N.3
Bunz, F.4
Biswal, S.5
-
10
-
-
84858797950
-
Sirtuins as regulators of metabolism and healthspan
-
COI: 1:CAS:528:DC%2BC38XjtlOktbw%3D, PID: 22395773
-
Houtkooper RH, Pirinen E, Auwerx J. Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol. 2012;13:225–38.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 225-238
-
-
Houtkooper, R.H.1
Pirinen, E.2
Auwerx, J.3
-
11
-
-
34548598664
-
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells
-
PID: 17624472
-
Sun Y, Sun D, Li F, Tian L, Li C, Li L, et al. Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. Lung Cancer. 2007;58:21–9.
-
(2007)
Lung Cancer
, vol.58
, pp. 21-29
-
-
Sun, Y.1
Sun, D.2
Li, F.3
Tian, L.4
Li, C.5
Li, L.6
-
12
-
-
84876359638
-
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
-
COI: 1:CAS:528:DC%2BC3sXlsFegu7c%3D, PID: 23562301
-
Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013;23:450–63.
-
(2013)
Cancer Cell
, vol.23
, pp. 450-463
-
-
Jeong, S.M.1
Xiao, C.2
Finley, L.W.3
Lahusen, T.4
Souza, A.L.5
Pierce, K.6
-
13
-
-
65249087389
-
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
COI: 1:CAS:528:DC%2BD1MXlvFamsL8%3D, PID: 19410549
-
Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 2009;137:560–70.
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
14
-
-
84869498851
-
SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice
-
COI: 1:CAS:528:DC%2BC38Xhs1Kls7jN, PID: 23085393
-
Nakamura Y, Ogura M, Ogura K, Tanaka D, Inagaki N. SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice. FEBS Lett. 2012;586:4076–81.
-
(2012)
FEBS Lett
, vol.586
, pp. 4076-4081
-
-
Nakamura, Y.1
Ogura, M.2
Ogura, K.3
Tanaka, D.4
Inagaki, N.5
-
15
-
-
81055122671
-
Sirt5 Is a NAD-dependent protein lysine demalonylase and desuccinylase
-
COI: 1:CAS:528:DC%2BC3MXhsVagtrnI, PID: 22076378
-
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, et al. Sirt5 Is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011;334:806–9.
-
(2011)
Science
, vol.334
, pp. 806-809
-
-
Du, J.1
Zhou, Y.2
Su, X.3
Yu, J.J.4
Khan, S.5
Jiang, H.6
-
16
-
-
84880791239
-
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways
-
COI: 1:CAS:528:DC%2BC3sXhtVWlsLrI, PID: 23806337
-
Park J, Chen Y, Tishkoff Daniel X, Peng C, Tan M, Dai L, et al. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013;50:919–30.
-
(2013)
Mol Cell
, vol.50
, pp. 919-930
-
-
Park, J.1
Chen, Y.2
Tishkoff Daniel, X.3
Peng, C.4
Tan, M.5
Dai, L.6
-
17
-
-
84861163510
-
Lysine succinylation and lysine malonylation in histones
-
COI: 1:CAS:528:DC%2BC38XotlWls78%3D, PID: 22389435
-
Xie Z, Dai J, Dai L, Tan M, Cheng Z, Wu Y, et al. Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics. 2012;11:100–7.
-
(2012)
Mol Cell Proteomics
, vol.11
, pp. 100-107
-
-
Xie, Z.1
Dai, J.2
Dai, L.3
Tan, M.4
Cheng, Z.5
Wu, Y.6
-
18
-
-
78650516004
-
Identification of lysine succinylation as a new post-translational modification
-
COI: 1:CAS:528:DC%2BC3cXhsFGgtrfM, PID: 21151122
-
Zhang Z, Tan M, Xie Z, Dai L, Chen Y, Zhao Y. Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol. 2011;7:58–63.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 58-63
-
-
Zhang, Z.1
Tan, M.2
Xie, Z.3
Dai, L.4
Chen, Y.5
Zhao, Y.6
-
19
-
-
84889636259
-
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks
-
COI: 1:STN:280:DC%2BC2c3kt1KmsA%3D%3D, PID: 24315375
-
Rardin Matthew J, He W, Nishida Y, Newman John C, Carrico C, Danielson Steven R, et al. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013;18:920–33.
-
(2013)
Cell Metab
, vol.18
, pp. 920-933
-
-
Rardin Matthew, J.1
He, W.2
Nishida, Y.3
Newman John, C.4
Carrico, C.5
Danielson Steven, R.6
-
20
-
-
84888294166
-
Dai D, Lu Q, Fei M, Li M, Wu X. Sirt2 suppresses glioma cell growth through targeting NF-κB–miR-21 axis
-
Yn L. Dai D, Lu Q, Fei M, Li M, Wu X. Sirt2 suppresses glioma cell growth through targeting NF-κB–miR-21 axis. Biochem Biophys Res Commun. 2013;441:661–7.
-
(2013)
Biochem Biophys Res Commun
, vol.441
, pp. 661-667
-
-
Yn, L.1
-
21
-
-
84902121544
-
The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BC2cXpsVKrt7k%3D, PID: 24571482
-
Chen Z, Ye X, Tang N, Shen S, Li Z, Niu X, et al. The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer. Br J Pharmacol. 2014;171:3196–211.
-
(2014)
Br J Pharmacol
, vol.171
, pp. 3196-3211
-
-
Chen, Z.1
Ye, X.2
Tang, N.3
Shen, S.4
Li, Z.5
Niu, X.6
-
22
-
-
0037242343
-
Mitochondrial DNA mutation correlates with stage progression and prognosis in non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BD3sXjtFKrur0%3D, PID: 12655558
-
Matsuyama W, Nakagawa M, Wakimoto J, Hirotsu Y, Kawabata M, Osame M. Mitochondrial DNA mutation correlates with stage progression and prognosis in non-small cell lung cancer. Hum Mutat. 2003;21:441–3.
-
(2003)
Hum Mutat
, vol.21
, pp. 441-443
-
-
Matsuyama, W.1
Nakagawa, M.2
Wakimoto, J.3
Hirotsu, Y.4
Kawabata, M.5
Osame, M.6
-
23
-
-
0039250954
-
Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
-
COI: 1:CAS:528:DC%2BD3cXhvF2qs78%3D, PID: 10720328
-
Fliss MS, Usadel H, Caballero OL, Wu L, Buta MR, Eleff SM, et al. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science. 2000;287:2017–9.
-
(2000)
Science
, vol.287
, pp. 2017-2019
-
-
Fliss, M.S.1
Usadel, H.2
Caballero, O.L.3
Wu, L.4
Buta, M.R.5
Eleff, S.M.6
-
24
-
-
77952309632
-
Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study
-
COI: 1:CAS:528:DC%2BC3cXlvVSqurc%3D, PID: 20176654
-
Hosgood HD, Liu C-S, Rothman N, Weinstein SJ, Bonner MR, Shen M, et al. Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis. 2010;31:847–9.
-
(2010)
Carcinogenesis
, vol.31
, pp. 847-849
-
-
Hosgood, H.D.1
Liu, C.-S.2
Rothman, N.3
Weinstein, S.J.4
Bonner, M.R.5
Shen, M.6
-
25
-
-
0034671206
-
Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460
-
COI: 1:CAS:528:DC%2BD3MXjsVOgsQ%3D%3D, PID: 11156422
-
Ferreira CG, Span SW, Peters GJ, Kruyt FAE, Giaccone G. Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res. 2000;60:7133–41.
-
(2000)
Cancer Res
, vol.60
, pp. 7133-7141
-
-
Ferreira, C.G.1
Span, S.W.2
Peters, G.J.3
Kruyt, F.A.E.4
Giaccone, G.5
-
26
-
-
63149129655
-
Bcl-2 Inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy
-
COI: 1:CAS:528:DC%2BD1MXitVOksLg%3D, PID: 19228717
-
Kang MH, Reynolds CP. Bcl-2 Inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res. 2009;15:1126–32.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1126-1132
-
-
Kang, M.H.1
Reynolds, C.P.2
-
27
-
-
37549026223
-
Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5
-
COI: 1:CAS:528:DC%2BD2sXhsVOktr7L, PID: 18054327
-
Nakamura Y, Ogura M, Tanaka D, Inagaki N. Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem Biophys Res Commun. 2008;366:174–9.
-
(2008)
Biochem Biophys Res Commun
, vol.366
, pp. 174-179
-
-
Nakamura, Y.1
Ogura, M.2
Tanaka, D.3
Inagaki, N.4
|