Epithelioid malignant peripheral nerve sheath tumor: Clinicopathologic analysis of 63 cases

American Journal of Surgical Pathology

Volumn 39, Issue 5, 2015, Pages 673-682

  Jo, Vickie Y ^a   Fletcher, Christopher D M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

epithelioid; INI1; malignant peripheral nerve sheath tumor; sarcoma; soft tissue

Indexed keywords

TUMOR MARKER;

ADOLESCENT; ADULT; AGED; CHILD; EPITHELIOID CELL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEURILEMOMA; PATHOLOGY; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; EPITHELIOID CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEURILEMMOMA; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84928585328     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000379     Document Type: Conference Paper

References (26)

1. McCormack LJ, Hazard JB, Dickson JA. Malignant epithelioid neurilemoma (schwannoma). Cancer. 1954;7:725-728.
2. Laskin WB, Weiss SW, Bratthauer GL. Epithelioid variant of malignant peripheral nerve sheath tumor (malignant epithelioid schwannoma). Am J Surg Pathol. 1991;15:1136-1145.
3. Lodding P, Kindblom LG, Angervall L. Epithelioid malignant schwannoma. A study of 14 cases. Virchows Arch A Pathol Anat Histopathol. 1986;409:433-451.
4. Woodruff JM, Selig AM, Crowley K, et al. Schwannoma (neurilemoma) with malignant transformation. A rare, distinctive peripheral nerve tumor. Am J Surg Pathol. 1994;18:882-895.
5. McMenamin ME, Fletcher CD. Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases. Am J Surg Pathol. 2001;25:13-25.
6. Hornick JL, Dal Cin P, Fletcher CD. Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol. 2009;33:542-550.
7. Carter JM, O'Hara C, Dundas G, et al. Epithelioid malignant peripheral nerve sheath tumor arising in a schwannoma, in a patient with "neuroblastoma-like" schwannomatosis and a novel germline SMARCB1 mutation. Am J Surg Pathol. 2012;36:154-160.
8. Rasbridge SA, Browse NL, Tighe JR, et al. Malignant nerve sheath tumour arising in a benign ancient schwannoma. Histopathology. 1989;14:525-528.
9. Mikami Y, Hidaka T, Akisada T, et al. Malignant peripheral nerve sheath tumor arising in benign ancient schwannoma: a case report with an immunohistochemical study. Pathol Int. 2000;50:156-161.
10. Yamamoto T, Minami R, Ohbayashi C. Subcutaneous malignant epithelioid schwannoma with cartilaginous differentiation. J Cutan Pathol. 2001;28:486-491.
11. Chen Y, Diamond AS, Vaheesan KR, et al. Retroperitoneal neurofibrosarcoma in a patient with neurofibromatosis. 2: a case report and review of the literature. Pediatr Pathol Mol Med. 2003; 22:375-381.
12. Endo M, Yamamoto H, Harimaya K, et al. Conventional spindle cell-type malignant peripheral nerve sheath tumor arising in a sporadic schwannoma. Hum Pathol. 2013;44:2845-2848.
13. Patil S, Perry A, Maccollin M, et al. Immunohistochemical analysis supports a role for INI1/SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas. Brain Pathol. 2008;18:517-519.
14. Coindre JM, Terrier P, Guillou L, et al. Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group. Cancer. 2001;91: 1914-1926.
15. Hagel C, Zils U, Peiper M, et al. Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors. J Neurooncol. 2007;82:187-192.
16. Smith K, Mezebish D, Williams JP, et al. Cutaneous epithelioid schwannomas: a rare variant of a benign peripheral nerve sheath tumor. J Cutan Pathol. 1998;25:50-55.
17. Kindblom LG, Meis-Kindblom JM, Havel G, et al. Benign epithelioid schwannoma. Am J Surg Pathol. 1998;22:762-770.
18. Saad AG, Mutema GK, Mutasim DF. Benign cutaneous epithelioid Schwannoma: case report and review of the literature. Am J Dermatopathol. 2005;27:45-47.
19. Rezanko T, Sari AA, Tunakan M, et al. Epithelioid schwannoma of soft tissue: unusual morphological variant causing a diagnostic dilemma. Ann Diagn Pathol. 2012;16:521-526.
20. Laskin WB, Fetsch JF, Lasota J, et al. Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol. 2005;29:39-51.
21. Gleason BC, Fletcher CD. Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases. Am J Surg Pathol. 2007;31:1813-1824.
22. Antonescu CR, Zhang L, Chang NE, et al. EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer. 2010;49:1114-1124.
23. Jo VY, Antonescu CR, Zhang L, et al. Cutaneous syncytial myoepithelioma: clinicopathologic characterization in a series of 38 cases. Am J Surg Pathol. 2013;37:710-718.
24. Flucke U, Palmedo G, Blankenhorn N, et al. EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases. Mod Pathol. 2011;24:1444-1450.
25. Guillou L, Wadden C, Coindre JM, et al. "Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series. Am J Surg Pathol. 1997;21: 130-146.
26. Nascimento AF, Bertoni F, Fletcher CD. Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. Am J Surg Pathol. 2007; 31:99-105.