Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

Clinical Microbiology and Infection

Volumn 21, Issue 4, 2015, Pages 347.e5-347.e8

  Yu, W L ^a,b   Lee, M F ^a   Tang, H J ^a,c   Chang, M C ^d   Walther Rasmussen, J ^e   Chuang, Y C ^a  

^a Chi Mei Medical Centre   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^d HUNGKUANG UNIVERSITY   (Taiwan)

^e Rigshospitalet   (Denmark)

Author keywords

Carbapenemase; Klebsiella pneumoniae; KPC 16; KPC 17; KPC 2

Indexed keywords

AMIKACIN; CEFAZOLIN; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; DORIPENEM; ERTAPENEM; FOSFOMYCIN; GENTAMICIN; IMIPENEM; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; TIGECYCLINE; ANTIINFECTIVE AGENT; BETA LACTAMASE; MINOCYCLINE;

AGED; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CASE REPORT; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EPIDEMIC; HUMAN; INSTITUTIONAL REVIEW; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MALE; MINIMUM INHIBITORY CONCENTRATION; MULTILOCUS SEQUENCE TYPING; PHYSICIAN; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; SPUTUM CULTURE; TAIWAN; ANALOGS AND DERIVATIVES; CLASSIFICATION; DRUG EFFECTS; ENZYMOLOGY; GENETICS; GENOTYPE; KLEBSIELLA INFECTIONS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR TYPING; PULSED FIELD GEL ELECTROPHORESIS;

KLEBSIELLA PNEUMONIAE;

AGED; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; COLISTIN; DISEASE OUTBREAKS; ELECTROPHORESIS, GEL, PULSED-FIELD; GENOTYPE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; MOLECULAR TYPING; TAIWAN;

EID: 84928556368     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2014.11.030     Document Type: Article

References (21)

1. Queenan A.M., Bush K. Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev 2007, 20:440-448.
2. Hirsch E.B., Tam V.H. Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection. JAntimicrob Chemother 2010, 65:1119-1125.
3. Qi Y., Wei Z., Ji S., Du X., Shen P., Yu Y. ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China. JAntimicrob Chemother 2011, 66:307-312.
4. Andrade L.N., Curiao T., Ferreira J.C., Longo J.M., Clímaco E.C., Martinez R., et al. Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil. Antimicrob Agents Chemother 2011, 55:3579-3583.
5. Chung K.P., Tseng S.P., Huang Y.T., Tsai T.H., Teng L.J., Hsueh P.R. Arrival of Klebsiella pneumoniae carbapenemase (KPC)-2 in Taiwan. JAntimicrob Chemother 2011, 66:1182-1184.
6. Lauderdale T.L., Shi Z.Y., Lin C.F., Lai J.F., Tan M.C., Wang J.T., et al. KPC-2-producing sequence type 11 Klebsiella pneumoniae detected in Taiwan. Antimicrob Agents Chemother 2012, 56:2207-2208.
7. Lee C.M., Liao C.H., Lee W.S., Liu Y.C., Mu J.J., Lee M.C., et al. Outbreak of Klebsiella pneumoniae carbapenemase-2-producing K.pneumoniae sequence type 11 in Taiwan in 2011. Antimicrob Agents Chemother 2012, 56:5016-5022.
8. Chiu S.K., Wu T.L., Chuang Y.C., Lin J.C., Fung C.P., Lu P.L., et al. National surveillance study on carbapenem non-susceptible Klebsiella pneumoniae in Taiwan: the emergence and rapid dissemination of KPC-2 carbapenemase. PLoS One 2013, 8:e69428.
9. Eckert C., Gautier V., Saladin-Allard M., Hidri N., Verdet C., Ould-Hocine Z., et al. Dissemination of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Paris, France. Antimicrob Agents Chemother 2004, 48:1249-1255.
10. Poirel L., Revathi G., Bernabeu S., Nordmann P. Detection of NDM-1-producing Klebsiella pneumoniae in Kenya. Antimicrob Agents Chemother 2011, 55:934-936.
11. Perez-Perez F.J., Hanson N.D. Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR. JClin Microbiol 2002, 40:2153-2162.
12. Ambler R.P., Coulson A.F., Frere J.M., Ghuysen J.M., Joris B., Forsman M., et al. Astandard numbering scheme for the class A beta-lactamases. Biochem J 1991, 276(Pt 1):269-270.
13. Tsai Y.K., Fung C.P., Lin J.C., Chen J.H., Chang F.Y., Chen T.L., et al. Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence. Antimicrob Agents Chemother 2011, 55:1485-1493.
14. Wu J.J., Wang L.R., Liu Y.F., Chen H.M., Yan J.J. Prevalence and characteristics of ertapenem-resistant Klebsiella pneumoniae isolates in a Taiwanese university hospital. Microb Drug Resist 2011, 17:259-266.
15. Zhang Y., Jiang X., Wang Y., Li G., Tian Y., Liu H., et al. Contribution of β-lactamases and porin proteins OmpK35 and OmpK36 to carbapenem resistance in clinical isolates of KPC-2-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2014, 58:1214-1217.
16. Kado C.I., Liu S.T. Rapid procedure for detection and isolation of large and small plasmids. JBacteriol 1981, 145:1365-1373.
17. Song W., Kim J.S., Kim H.S., Jeong S.H., Yong D., Lee K.M. Emergence of Escherichia coli isolates producing conjugative plasmid-mediated DHA-1 β-lactamase in a Korean university hospital. JHosp Infect 2006, 63:459-464.
18. Picao R.C., Cardoso J.P., Campana E.H., Nicoletti A.G., Petrolini F.V., Assis D.M., et al. The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage. Diagn Microbiol Infect Dis 2013, 76:80-85.
19. Sheng J.F., Li J.J., Tu S., Sheng Z.K., Bi S., Zhu M.H., et al. blaKPC and rmtB on a single plasmid in Enterobacter amnigenus and Klebsiella pneumoniae isolates from the same patient. Eur J Clin Microbiol Infect Dis 2012, 31:1585-1591.
20. Chen Y.T., Lin J.C., Fung C.P., Lu P.L., Chuang Y.C., Wu T.L., et al. KPC-2-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan. JAntimicrob Chemother 2014, 69:628-631.
21. Diancourt L., Passet V., Verhoef J., Grimont P.A., Brisse S. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. JClin Microbiol 2005, 43:4178-4182.