Porous deproteinized bovine bone scaffold with three-dimensional localized drug delivery system using chitosan microspheres

BioMedical Engineering Online

Volumn 14, Issue 1, 2015, Pages

  Li, Qing ^a,b   Zhou, Gang ^c   Yu, Xin ^c   Wang, Tong ^b   Xi, Yuan ^c   Tang, Zhihui ^b  

^a PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

^b NATIONAL ENGINEERING LABORATORY FOR DIGITAL AND MATERIAL TECHNOLOGY OF STOMATOLOGY   (China)

^c BEIHANG UNIVERSITY   (China)

Author keywords

Deproteinized bovine bone (DBB); Drug delivery system; Microsphere; Scaffold

Indexed keywords

ASSAYS; BIOACTIVITY; BIOASSAY; BIOCOMPATIBILITY; BONE; CELL CULTURE; CHITIN; CHITOSAN; CONTROLLED DRUG DELIVERY; MAMMALS; MICROSPHERES; SCAFFOLDS; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING;

BONE MORPHOGENETIC PROTEIN-2; BOVINE BONE; BOVINE CANCELLOUS BONES; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; FOURIER TRANSFORM INFRARED; OSTEOINDUCTIVE PROPERTIES; TISSUE ENGINEERING APPLICATIONS;

SCAFFOLDS (BIOLOGY);

BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATE; CHITOSAN; GROWTH FACTOR; HYDROXYAPATITE; MICROSPHERE; BIOCOMPATIBLE COATED MATERIAL; DRUG IMPLANT; MESSENGER RNA;

ALLOGRAFT; ANIMAL EXPERIMENT; ARTICLE; AUTOGRAFT; BIOCOMPATIBILITY; BONE GROWTH; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMUR; FREEZE DRYING; IN VITRO STUDY; INFRARED SPECTROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; THREE DIMENSIONAL IMAGING; TIBIA; TISSUE ENGINEERING; TRABECULAR BONE; X RAY DIFFRACTION; ANIMAL; BIOSYNTHESIS; BONE; BOVINE; CELL CULTURE; CYTOLOGY; DEVICES; DRUG EFFECTS; DRUG IMPLANT; EMBRYOLOGY; GENE EXPRESSION PROFILING; MATERIALS TESTING; METABOLISM; OSTEOBLAST; POROSITY; SCANNING ELECTROCHEMICAL MICROSCOPY; SKULL; TISSUE SCAFFOLD;

BOVINAE;

ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CATTLE; CELLS, CULTURED; CHITOSAN; COATED MATERIALS, BIOCOMPATIBLE; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; FEMUR; GENE EXPRESSION PROFILING; MATERIALS TESTING; MICE; MICROSCOPY, ELECTROCHEMICAL, SCANNING; MICROSPHERES; OSTEOBLASTS; POROSITY; RNA, MESSENGER; SKULL; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TIBIA; TISSUE SCAFFOLDS;

EID: 84928541071     PISSN: None     EISSN: 1475925X     Source Type: Journal    
DOI: 10.1186/s12938-015-0028-2     Document Type: Article

References (18)

1. Shang F, Ming L, Zhou Z, Yu Y, Sun J, Ding Y, et al. The effect of licochalcone A on cell-aggregates ECM secretion and osteogenic differentiation during bone formation in metaphyseal defects in ovariectomized rats. Biomaterials. 2014;35:2789-97.
2. Thormann U, Ray S, Sommer U, Elkhassawna T, Rehling T, Hundgeburth M, et al. Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats. Biomaterials. 2013;34:8589-98.
3. Meyer Jr RA, Tsahakis PJ, Martin DF, Banks DM, Harrow ME, Kiebzak GM. Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats. J Orthop Res. 2001;19:428-35.
4. Namkung-Matthai H, Appleyard R, Jansen J, Hao Lin J, Maastricht S, Swain M, et al. Osteoporosis influences the early period of fracture healing in a rat osteoporotic model. Bone. 2001;28:80-6.
5. Fairbairn NG, Randolph MA, Redmond RW. The clinical applications of human amnion in plastic surgery. J Plast Reconstr Aesthet Surg. 2014;67:662-75.
6. Chen Z, Wu C, Gu W, Klein T, Crawford R, Xiao Y. Osteogenic differentiation of bone marrow MSCs by beta-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials. 2014;35:1507-18.
7. Muller KH, Motskin M, Philpott AJ, Routh AF, Shanahan CM, Duer MJ, et al. The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages. Biomaterials. 2014;35:1074-88.
8. Van Manen EH, Zhang W, Walboomers XF, Vazquez B, Yang F, Ji W, et al. The influence of electrospun fibre scaffold orientation and nano-hydroxyapatite content on the development of tooth bud stem cells in vitro. Odontology. 2014;102:14-21.
9. Wiltfang J, Jatschmann N, Hedderich J, Neukam FW, Schlegel KA, Gierloff M. Effect of deproteinized bovine bone matrix coverage on the resorption of iliac cortico-spongeous bone grafts - a prospective study of two cohorts. Clin Oral Implants Res. 2014;25:e127-32.
10. Garcia EV, Valdecantos PA, Barrera D, Roldan-Olarte M, Miceli DC. Bone morphogenetic proteins in the bovine oviduct: differential expression of BMP-5 in the isthmus during the estrous cycle. Theriogenology. 2014;81:1032-41.
11. Rahman CV, Ben-David D, Dhillon A, Kuhn G, Gould TW, Muller R, et al. Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model. J Tissue Eng Regen Med. 2014;8:59-66.
12. Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, et al. Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. J Biol Chem. 2014;289:9865-79.
13. Almodovar J, Guillot R, Monge C, Vollaire J, Selimovic S, Coll JL, et al. Spatial patterning of BMP-2 and BMP-7 on biopolymeric films and the guidance of muscle cell fate. Biomaterials. 2014;35:3975-85.
14. Allouche FN, Guibal EE, Mameri N. Preparation of a new chitosan-based materials and its application for mercury sorption. Colloids Surf A Physicochem Eng Asp. 2014;446:224-32.
15. Abdelgawad AM, Hudson SM, Rojas OJ. Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems. Carbohydr Polym. 2014;100:166-78.
16. Ferrand A, Eap S, Richert L, Lemoine S, Kalaskar D, Demoustier-Champagne S, et al. Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with chitosan-based nanoreservoirs of growth factors. Macromol Biosci. 2014;14:45-55.
17. Liu Y, De Groot K, Hunziker EB. BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model. Bone. 2005;36:745-57.
18. Meng J, Zhang Y, Qi X, Kong H, Wang C, Xu Z, et al. Paramagnetic nanofibrous composite films enhance the osteogenic responses of pre-osteoblast cells. Nanoscale. 2010;2:2565-9.