Risk factors for mortality in patients with bloodstream infections caused by carbapenem-resistant Pseudomonas aeruginosa: Clinical impact of bacterial virulence and strains on outcome

Diagnostic Microbiology and Infectious Disease

Volumn 80, Issue 2, 2014, Pages 130-135

  Jeong, Su Jin ^a   Yoon, Sang Sun ^a   Bae, Il Kwon ^b   Jeong, Seok Hoon ^a   Kim, June Myung ^a   Lee, Kyungwon ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Silla University   (South Korea)

Author keywords

Carbapenem resistant Pseudomonas aeruginosa; Mortality; Pseudomonas aeruginosa bloodstream infection; Virulence factors

Indexed keywords

AMINOGLYCOSIDE; CARBAPENEM; CIPROFLOXACIN; ELASTASE; GLYCOPEPTIDE; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE; PANCREATIC ELASTASE; VIRULENCE FACTOR;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; APACHE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; BIOFILM; BLOODSTREAM INFECTION; CARBAPENEM RESISTANT PSEUDOMONAS AERUGINOSA; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTILOCUS SEQUENCE TYPING; NEUTROPHIL COUNT; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; RISK FACTOR; AGED; BACTEREMIA; COHORT ANALYSIS; DRUG EFFECTS; EPIDEMIOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PSEUDOMONAS INFECTION; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; SOUTH KOREA; TEACHING HOSPITAL; TREATMENT OUTCOME; VIRULENCE;

ADULT; AGED; ANTI-BACTERIAL AGENTS; BACTEREMIA; BETA-LACTAM RESISTANCE; BIOFILMS; CARBAPENEMS; COHORT STUDIES; FEMALE; HOSPITALS, TEACHING; HUMANS; MALE; MIDDLE AGED; PANCREATIC ELASTASE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VIRULENCE; VIRULENCE FACTORS;

EID: 84928522861     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2014.07.003     Document Type: Article

References (34)

1. ATS, IDSA Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005, 171(4):388-416.
2. Blot S., Vandewoude K., De Bacquer D., Colardyn F. Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization. Clin Infect Dis 2002, 34(12):1600-1606.
3. Bone R.C., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101(6):1644-1655.
4. Caballero A.R., Moreau J.M., Engel L.S., Marquart M.E., Hill J.M., O'Callaghan R.J. Pseudomonas aeruginosa protease IV enzyme assays and comparison to other Pseudomonas proteases. Anal Biochem 2001, 290(2):330-337.
5. Charlson M.E., Pompei P., Ales K.L., MacKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987, 40(5):373-383.
6. Clinical and Laboratory Standards Institute (CLSI) Performance standards for antimicrobial susceptibility testing; 22nd informational supplement 2012, CLSI, Wayne, PA, USA.
7. Costerton J.W., Stewart P.S., Greenberg E.P. Bacterial biofilms: a common cause of persistent infections. Science 1999, 284(5418):1318-1322.
8. Curran B., Jonas D., Grundmann H., Pitt T., Dowson C.G. Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa. J Clin Microbiol 2004, 42(12):5644-5649.
9. Fricks Lima J., Hendrickson C.M., Allgaier M., Zhuo H., Wiener Kronish J.P., Lynch S.V., et al. Differences in biofilm formation and antimicrobial resistance of Pseudomonas aeruginosa isolated from airways of mechanically ventilated patients and cystic fibrosis patients. Int J Antimicrob Agents 2011, 37(4):309-315.
10. Garner J.S., Jarvis W.R., Emori T.G., Horan T.C., Hughes J.M. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988, 16(3):128-140.
11. Gasink L.B., Fishman N.O., Weiner M.G., Nachamkin I., Bilker W.B., Lautenbach E. Fluoroquinolone-resistant Pseudomonas aeruginosa: assessment of risk factors and clinical impact. Am J Med 2006, 119(6):526.e19-526.e25.
12. Gaynes R., Edwards J.R. Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis 2005, 41(6):848-854.
13. Glupczynski Y., Bogaerts P., Deplano A., Berhin C., Huang T.D., Van Eldere J., et al. Detection and characterization of class A extended-spectrum-beta-lactamase-producing Pseudomonas aeruginosa isolates in Belgian hospitals. J Antimicrob Chemother 2010, 65(5):866-871.
14. Hodge W., Ciak J., Tramont E.C. Simple method for detection of penicillinase-producing Neisseria gonorrhoeae. J Clin Microbiol 1978, 7(1):102-103.
15. Khan N.H., Ahsan M., Yoshizawa S., Hosoya S., Yokota A., Kogure K. Multilocus sequence typing and phylogenetic analyses of Pseudomonas aeruginosa Isolates from the ocean. Appl Environ Microbiol 2008, 74(20):6194-6205.
16. Kipnis E., Sawa T., Wiener-Kronish J. Targeting mechanisms of Pseudomonas aeruginosa pathogenesis. Med Mal Infect 2006, 36(2):78-91.
17. Knaus W.A., Draper E.A., Wagner D.P., Zimmerman J.E. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13(10):818-829.
18. Koh T.H., Khoo C.T., Tan T.T., Arshad M.A., Ang L.P., Lau L.J., et al. Multilocus sequence types of carbapenem-resistant Pseudomonas aeruginosa in Singapore carrying metallo-beta-lactamase genes, including the novel bla(IMP-26) gene. J Clin Microbiol 2010, 48(7):2563-2564.
19. Kouda S., Ohara M., Onodera M., Fujiue Y., Sasaki M., Kohara T., et al. Increased prevalence and clonal dissemination of multidrug-resistant Pseudomonas aeruginosa with the blaIMP-1 gene cassette in Hiroshima. J Antimicrob Chemother 2009, 64(1):46-51.
20. Kudoh I., Wiener-Kronish J.P., Hashimoto S., Pittet J.F., Frank D. Exoproduct secretions of Pseudomonas aeruginosa strains influence severity of alveolar epithelial injury. Am J Physiol 1994, 267(5):L551-L556.
21. Kurahashi K., Kajikawa O., Sawa T., Ohara M., Gropper M.A., Frank D.W., et al. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J Clin Invest 1999, 104(6):743-750.
22. Lautenbach E., Weiner M.G., Nachamkin I., Bilker W.B., Sheridan A., Fishman N.O. Imipenem resistance among Pseudomonas aeruginosa isolates: risk factors for infection and impact of resistance on clinical and economic outcomes. Infect Control Hosp Epidemiol 2006, 27(9):893-900.
23. Le Gall J.R., Lemeshow S., Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993, 270(24):2957-2963. [Chicago, Ill.].
24. Lee K., Lim Y.S., Yong D., Yum J.H., Chong Y. Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-beta-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp. J Clin Microbiol 2003, 41(10):4623-4629.
25. Livermore D.M. beta-Lactamases in laboratory and clinical resistance. Clin Microbiol Rev 1995, 8(4):557-584.
26. Livermore D.M. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?. Clin Infect Dis 2002, 34(5):634-640.
27. Morihara K. Production of elastase and proteinase by pseudomonas aeruginosa. J Bacteriol 1964, 88:745-757.
28. O'Toole G.A., Kolter R. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol 1998, 30(2):295-304.
29. Poole K. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Mol Microbiol Biotechnol 2001, 3(2):255-264.
30. Sadikot R.T., Blackwell T.S., Christman J.W., Prince A.S. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med 2005, 171(11):1209-1223.
31. Seok Y., Bae I.K., Jeong S.H., Kim S.H., Lee H., Lee K. Dissemination of IMP-6 metallo-beta-lactamase-producing Pseudomonas aeruginosa sequence type 235 in Korea. J Antimicrob Chemother 2011, 66(12):2791-2796.
32. Vidal F., Mensa J., Almela M., Martnez J.A., Marco F., Casals C., et al. Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment. Analysis of 189 episodes. Arch Intern Med 1996, 156(18):2121-2126.
33. Walsh T.R., Toleman M.A., Poirel L., Nordmann P. Metallo-beta-lactamases: the quiet before the storm?. Clin Microbiol Rev 2005, 18(2):306-325.
34. Yoon S.S. Anaerobiosis of Pseudomonas aeruginosa: implications for treatments of airway infection. J Bacteriol Virol 2010, 40(2):59-66.