Circulating tumor cells found in patients with localized and advanced pancreatic cancer

Pancreas

Volumn 44, Issue 4, 2015, Pages 547-550

  Kulemann, Birte ^a,b   Pitman, Martha B ^a   Liss, Andrew S ^a   Valsangkar, Nakul ^a   Fernández Del Castillo, Carlos ^a   Lillemoe, Keith D ^a   Hoeppner, Jens ^b   Mino Kenudson, Mari ^a   Warshaw, Andrew L ^a   Thayer, Sarah P ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

circulating tumor cells; KRAS mutation; pancreatic cancer

Indexed keywords

CELL DNA; K RAS PROTEIN; KRAS PROTEIN, HUMAN; PROTEIN P21; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CELL ISOLATION; CIRCULATING TUMOR CELL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLOGY; EXPLORATORY RESEARCH; FEMALE; FILTRATION DEVICE; GENE MUTATION; GENERAL DEVICE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MALE; MUTATIONAL ANALYSIS; PANCREAS ADENOCARCINOMA; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; BLOOD; CANCER STAGING; CASE CONTROL STUDY; CELL SEPARATION; CLINICAL TRIAL; FILTRATION; GENETICS; MIDDLE AGED; MUTATION; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; SINGLE BLIND PROCEDURE; TUMOR EMBOLISM;

ADULT; AGED; BIOMARKERS, TUMOR; CARCINOMA, PANCREATIC DUCTAL; CASE-CONTROL STUDIES; CELL SEPARATION; FEMALE; FILTRATION; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASM STAGING; NEOPLASTIC CELLS, CIRCULATING; PANCREATIC NEOPLASMS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS P21(RAS); SINGLE-BLIND METHOD;

EID: 84928487016     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0000000000000324     Document Type: Article

References (24)

1. Jemal A, Siegel R, Xu J, et al. Cancer statistics 2010. CA Cancer J Clin. 2010;60:277-300.
2. Sant M, Allemani C, Santaquilani M, et al. EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary. Eur J Cancer. 2009;45:931-991.
3. Fernández-del Castillo C,Morales-OyarvideV,McGrath D, et al. Evolution of the whipple procedure at the Massachusetts General Hospital. Surgery. 2012;152(3 suppl 1):S56-S63.
4. Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817-1825.
5. Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, et al. Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Surgery. 2012; 152(3 suppl 1):S43-S49.
6. Croome KP, Jayaraman S, Schlachta CM. Preoperative staging of cancer of the pancreatic head: is there room for improvement? Can J Surg. 2010;53: 171-174.
7. Marrinucci D, Bethel K, Bruce RH, et al. Case study of the morphologic variation of circulating tumor cells. Hum Pathol. 2007;38:514-519.
8. Khoja L, Backen A, Sloane R, et al. A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker. Br J Cancer. 2012; 106:508-516.
9. Nagrath S, Sequist LV, Maheswaran S. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature. 2007;450: 1235-1239.
10. Cohen SJ, Punt CJ, Iannotti N, et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26: 3213-3221.
11. de Bono JS, Scher HI, Montgomery RB, et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res. 2008;14:6302-6309.
12. Maheswaran S, Sequist LV, Nagrath S, et al. Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med. 2008;359: 366-377.
13. Stott SL, Lee RJ, Nagrath S, et al. Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci Transl Med. 2010;2:25ra23.
14. Gorges TM, Tinhofer I, Drosch M, et al. Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. BMC Cancer. 2012;12:178.
15. Rhim AD, Mirek ET, Aiello NM, et al. EMT and dissemination precede pancreatic tumor formation. Cell. 2012;148:349-361.
16. Pinzani P, Salvadori B, Simi L, et al. Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection. Hum Pathol. 2006;37:711-718.
17. Hofman V, Long E, Ilie M, et al. Morphological analysis of circulating tumour cells in patients undergoing surgery for non-small cell lung carcinoma using the isolation by size of epithelial tumour cell (ISET) method. Cytopathology. 2012;23:30-38.
18. Desitter I, Guerrouahen BS, Benali-Furet N, et al. A new device for rapid isolation by size and characterization of rare circulating tumor cells. Anticancer Res. 2011;31:427-441.
19. Bidard FC, Huguet F, Louvet C, et al. Circulating tumor cells in locally advanced pancreatic adenocarcinoma: the ancillary CirCe 07 study to the LAP 07 trial. Ann Oncol. 2013;24:2057-2061.
20. Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53: 549-554.
21. Beau-Faller M, Legrain M, Voegeli AC, et al. Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping. Br J Cancer. 2009; 100:985-992.
22. Rhim AD, Thege FI, Santana SM, et al. Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions. Gastroenterology. 2014;146:647-651.
23. Morris JP 4th, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 2010;10:683-695.
24. Yu M, Ting DT, Stott SL, et al. RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature. 2012;487: 510-513.