Effect of combining tramadol and morphine in adult surgical patients: A systematic review and meta-analysis of randomized trials

British Journal of Anaesthesia

Volumn 114, Issue 3, 2015, Pages 384-395

  Martinez, V ^a,b,c   Guichard, L ^a   Fletcher, D ^a,b,c  

^a RAYMOND POINCARÉ HOSPITAL   (France)

^b HÔPITAL AMBROISE PARÉ   (France)

^c LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Balanced analgesia; Meta analysis; Postoperative pain; Surgery; Tramadol

Indexed keywords

MORPHINE; PLACEBO; TRAMADOL; NARCOTIC ANALGESIC AGENT;

ADULT; ADVERSE OUTCOME; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COCHRANE LIBRARY; CONTROLLED CLINICAL TRIAL (TOPIC); DIZZINESS; DRUG EFFECT; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; EMBASE; HEADACHE; HUMAN; INCIDENCE; META ANALYSIS; NAUSEA AND VOMITING; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PAIN INTENSITY; POSTOPERATIVE ANALGESIA; POSTOPERATIVE CARE; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; SEDATION; SHIVERING; SURGICAL APPROACH; SURGICAL PATIENT; SYSTEMATIC REVIEW; TACHYCARDIA; VISUAL ANALOG SCALE; XEROSTOMIA; ADVERSE EFFECTS; DRUG COMBINATION; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROCEDURES; SURGERY;

ADULT; ANALGESICS, OPIOID; DRUG THERAPY, COMBINATION; HUMANS; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SURGICAL PROCEDURES, OPERATIVE; TRAMADOL;

EID: 84928481862     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeu414     Document Type: Review

References (40)

1. Kehlet H, Dahl JB. The value of 'multimodal' or 'balanced analgesia' in postoperative pain treatment. Anesth Analg 1993; 77: 1048-56
2. Institute of Medicine (US). Committee on Advancing Pain Research, Care, and Education Board on Health Sciences Policy. Relieving Pain in America:A Blueprint for Transforming Prevention, Care, Education, andResearch.Washington, DC:TheNationalAcademiesPress,2011
3. Fletcher D, Aubrun F. Long texts for the formalized recommendation of experts on management of postoperative pain. Ann Fr Anesth Reanim 2009; 28: 1-2
4. Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet 2004; 43: 879-923
5. Desmeules JA, Piguet V, Collart L, Dayer P. Contribution of monoaminergic modulation to the analgesic effect of tramadol. Br J Clin Pharmacol 1996; 41: 7-12
6. Scott LJ,PerryCM. Tramadol:areviewof its use in perioperativepain. Drugs 2000; 60: 139-76
7. Stubhaug A, Grimstad J, Breivik H. Lack of analgesic effect of 50 and100 mg oral tramadol after orthopaedic surgery: a randomized, double-blind, placebo and standard active drug comparison. Pain 1995; 62: 111-8
8. Antila H, Manner T, Kuurila K, Salantera S, Kujala R, Aantaa R. Ketoprofen and tramadol for analgesia during early recovery after tonsillectomy in children. Paediatr Anaesth 2006; 16: 548-53
9. But AK, Erdil F, Yucel A, Gedik E, Durmus M, Ersoy MO. The effects of single-dose tramadol on post-operative pain and morphine requirements after coronary artery bypass surgery. Acta Anaesthesiol Scand 2007; 51: 601-6
10. Kocabas S, Karaman S, Uysallar E, Firat V. The use of tramadol and morphine for pain relief after abdominal hysterectomy. Clin Exp Obstet Gynecol 2005; 32: 45-8
11. Ozbakis Akkurt BC, Inanoglu K, Turhanoglu S, Asfuroglu Z. Effects of dexmedetomidine and tramadol administered before induction of anesthesia on postoperative pain. (Anesteziinduksiyonu oncesiuygulanan tramadol veya deksmedetomidin'in postoperatif agri uzerine etkileri). Anestezi Dergis 2008; 16: 183-7
12. Spacek A, Goraj E, Neiger FX, Jarosz J, Kress HG. Superior postoperative analgesic efficacy of a continuous infusion of tramadol and dipyrone (metamizol) versus tramadol alone. Acute Pain 2003; 5: 3-9
13. Stiller CO, Lundblad H,Weidenhielm L, et al. The addition of tramadol to morphine via patient-controlled analgesia does not lead to better post-operative pain relief after total knee arthroplasty. Acta Anaesthesiol Scand 2007; 51: 322-30
14. Stratigopoulou P, Vasileiou I, Stefaniotou A, Melissopoulou T, Lampadariou A, Tsinari K. Comparison of morphine versus morphine plus bolus tramadol for postoperative analgesia in morbidly obese patients. Eur J Anaesthesiol 2012; 29: 14AP2-8
15. Thienthong S, Taesiri W, Utsahapanich S, Krisanaprakornkit W, Thaninsurat N, Klaichanad C. Two doses of oral sustained-release tramadol do not reduce pain or morphine consumption after modified radical mastectomy: a randomized, double-blind, placebocontrolled trial. J Med Assoc Thai 2004; 87: 24-32
16. Unlugenc H, Ozalevli M, Gunes Y, Guler T, Isik G. Pre-emptive analgesic efficacy of tramadol compared with morphine after majorabdominal surgery. Br J Anaesth 2003; 91: 209-13
17. Webb AR, Leong S, Myles PS, Burn SJ. The addition of a tramadol infusion to morphine patient-controlled analgesia after abdominal surgery: a double-blinded, placebo-controlled randomized trial. Anesth Analg 2002; 95: 1713-8
18. Wilder-Smith CH, Hill L, Dyer RA, Torr G, Coetzee E. Postoperative sensitization and pain after cesarean delivery and the effects of single im doses of tramadol and diclofenac alone and in combination. Anesth Analg 2003; 97: 526-33
19. Marcou TA, Marque S, Mazoit JX, BenhamouD. The median effective dose of tramadol and morphine for postoperative patients: a study of interactions. Anesth Analg 2005; 100: 469-74
20. Higgins J, Green S. Guide to the contents of a Cochrane protocol and review.CochraneHandbookfor SystematicReviewsof Interventions, Version 5.1.0. Chapter 4. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org (updated March 2011)
21. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Br Med J 2009; 339: b2700
22. Lefebvre C, Manheimer E, Glanville J. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 (Updated March 2011). Chapter 6.4: Searching for studies. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org, 2008
23. Visser K, Hassink EA, Bonsel GJ, Moen J, Kalkman CJ. Randomized controlled trial of total intravenous anesthesia with propofol versus inhalation anesthesia with isoflurane-nitrous oxide: postoperative nausea with vomiting and economic analysis. Anesthesiology 2001; 95: 616-26
24. Apfel CC, Turan A, Souza K, Pergolizzi J, Hornuss C. Intravenous acetaminophen reduces postoperative nausea and vomiting: a systematic review and meta-analysis. Pain 2013; 154: 677-89
25. Higgins JP, White IR, Wood AM. Imputation methods for missing outcome data in meta-analysis of clinical trials. Clin Trials 2008; 5: 225-39
26. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005; 5: 13
27. Sparks DA, Fanciullo GJ. Opioids. In: Lynch ME, Craig KD, Peng PWH, eds. Clinical Pain Management: A Practical Guide, 2011: 128-34
28. Guler A, Celebioglu B, Sahin A, Beksac S. Comparison of preemptive administration of lornoxicam and tramadol on postoperative analgesia.: Preemptif olarak kullanilan lornoksikam ve tramadolun postoperatif analjeziye katkilarinin karsilastirilmasi. Anestezi Dergizi 2013; 21: 43-8
29. Elhakim M, Abd El-Megid W, Metry A, El-hennawy A, El-Queseny K. Analgesic andantacid properties of i.m. tramadol given before Caesarean section under general anaesthesia. Br J Anaesth 2005; 95: 811-5
30. Duthie DJ. Remifentanil and tramadol. Br J Anaesth 1998; 81: 51-7
31. Maund E, McDaid C, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth 2011; 106: 292-7
32. Elia N, Lysakowski C, Tramer MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2inhibitorsandpatient-controlled analgesiamorphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 2005; 103: 1296-304
33. De Oliveira GS Jr, Agarwal D, Benzon HT. Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials. Anesth Analg 2012; 114: 424-33
34. Evans MS, Lysakowski C, Tramer MR. Nefopam for the prevention of postoperative pain: quantitative systematic review. Br J Anaesth 2008; 101: 610-7
35. Remy C, Marret E, Bonnet F. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth 2005; 94: 505-13
36. Marret E, Kurdi O, Zufferey P, Bonnet F. Effects of nonsteroidal antiinflammatory drugsonpatient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology 2005; 102: 1249-60
37. Ilias W, Jansen M. Pain control after hysterectomy: an observerblind, randomised trial of lornoxicam versus tramadol. Br J Clin Pract 1996; 50: 197-202
38. Cossmann M, Kohnen C, Langford R, McCartney C. Tolerance and safety of tramadol use. Results of international studies and data from drug surveillance. Drugs 1997; 53 (Suppl. 2): 50-62
39. Cepeda MS, Africano JM, Polo R, Alcala R, Carr DB. What decline in pain intensity is meaningful to patients with acute pain? Pain 2003; 105: 151-7
40. Garcia Quetglas E, Azanza JR, Cardenas E, Sadaba B, Campanero MA. Stereoselective pharmacokinetic analysis of tramadol and its main phase I metabolites in healthy subjects after intravenous and oral administration of racemic tramadol. Biopharm Drug Dispos 2007; 28: 19-33