Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer

Oncotarget

Volumn 6, Issue 10, 2015, Pages 8300-8312

  Hoekstra, Elmer ^a   Kodach, Liudmila L ^b   Das, Asha M ^a   Ruela de Sousa, Roberta R ^c   Ferreira, Carmen V ^c   Hardwick, James C ^b   Janneke van der Woude, C ^a   Peppelenbosch, Maikel P ^a   ten Hagen, Timo L M ^a   Fuhler, Gwenny M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Colorectal cancer; Kinases and phosphatases; Metastasis; Signal transduction

Indexed keywords

ACID PHOSPHATASE; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROURACIL; LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE SHP 1; UNCLASSIFIED DRUG; TRANSCRIPTOME;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER STAGING; CELL DEATH; CELL MIGRATION; CELL SURVIVAL; CELL VIABILITY; COLON BIOPSY; COLORECTAL ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM CELL; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; VERY ELDERLY; COLORECTAL TUMOR; ENZYMOLOGY; GENETICS; METABOLISM; METASTASIS; MOLECULAR WEIGHT; PATHOLOGY; PHOSPHORYLATION;

CELL SURVIVAL; COLORECTAL NEOPLASMS; HUMANS; MOLECULAR WEIGHT; NEOPLASM METASTASIS; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASES; SIGNAL TRANSDUCTION; TRANSCRIPTOME; UP-REGULATION;

EID: 84928399921     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3224     Document Type: Article

References (34)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. Ca-Cancer J Clin. 2013; 63:11-30.
2. Howlader N NA, Krapcho M, Garshell J, Neyman N, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2010. National Cancer Institute. Bethesda, MD 2013. http://seer.cancer.gov/csr/1975_2010/
3. Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001; 411:355-65.
4. Gschwind A, Fischer OM, Ullrich A. Timeline-The discovery of receptor tyrosine kinases: targets for cancer therapy. Nature Reviews Cancer. 2004; 4:361-70.
5. Van Cutsem E, Kohne CH, Hitre E, Zaluski J, Chien CRC, Makhson A, D'Haens G, Pinter T, Lim R, Bodoky G, Roh JK, Folprecht G, Ruff P, Stroh C, Tejpar S, Schlichting M, Nippgen J, Rougier P. Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer. New Engl J Med. 2009; 360:1408-17.
6. Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Cupit L, Wagner A, Laurent D, Grp CS. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013; 381:303-12.
7. Hoekstra E, Peppelenbosch MP, Fuhler GM. The role of protein tyrosine phosphatases in colorectal cancer. Bba-Rev Cancer. 2012; 1826:179-88.
8. Chiarugi P, Taddei ML, Schiavone N, Papucci L, Giannoni E, Fiaschi T, Capaccioli S, Raugei G, Ramponi G. LMW-PTP is a positive regulator of tumor onset and growth. Oncogene. 2004; 23:3905-14.
9. Malentacchi F, Marzocchini R, Gelmini S, Orlando C, Serio M, Ramponi G, Raugei G. Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers. Biochem Biophys Res Commun. 2005; 334:875-83.
10. Kikawa KD, Vidale DR, Van Etten RL, Kinch MS. Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. J Biol Chem. 2002; 277:39274-9.
11. Taddei ML, Chiarugi P, Cirri P, Buricchi F, Fiaschi T, Giannoni E, Talini D, Cozzi G, Formigli L, Raugei G, Ramponi G. Beta-catenin interacts with low-molecularweight protein tyrosine phosphatase leading to cadherinmediated cell-cell adhesion increase. Cancer Res. 2002; 62:6489-99.
12. Chiarugi P, Cirri P, Raugei G, Camici G, Dolfi F, Berti A, Ramponi G. PDGF receptor as a specific in vivo target for low M(r) phosphotyrosine protein phosphatase. FEBS Lett. 1995; 372:49-53.
13. Lee JK, Edderkaoui M, Truong P, Ohno I, Jang KT, Berti A, Pandol SJ, Gukovskaya AS. NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases. Gastroenterology. 2007; 1637-48.
14. Rigacci S, Talini D, Berti A. LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain. Biochem Biophys Res Commun. 2003; 312:360-6.
15. Baek SJ, Yang S, Kang TW, Park SM, Kim YS, Kim SY. MENT: Methylation and expression database of normal and tumor tissues. Gene. 2013; 518:194-200.
16. Zhou M, Van Etten RL. Structural basis of the tight binding of pyridoxal 5 '-phosphate to a low molecular weight protein tyrosine phosphatase. Biochemistry. 1999; 38:2636-46.
17. Sieg DJ, Hauck CR, Schlaepfer DD. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. Journal of Cell Science. 1999; 2677-91.
18. Kato H, Semba S, Miskad UA, Seo Y, Kasuga M, Yokozaki H. High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: A predictive molecular marker of metachronous liver and lung metastases. Clinical Cancer Research. 2004; 10:7318-28.
19. Peng L, Xing X, Li W, Qu L, Meng L, Lian S, Jiang B, Wu J, Shou C. PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. Mol Cancer. 2009; 8:110.
20. Sadakata H, Okazawa H, Sato T, Supriatna Y, Ohnishi H, Kusakari S, Murata Y, Ito T, Nishiyama U, Minegishi T, Harada A, Matozaki T. SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. Genes Cells. 2009; 295-308.
21. Seo Y, Matozaki T, Tsuda M, Hayashi Y, Itoh H, Kasuga M. Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers. Biochem Biophys Res Commun. 1997; 231:705-11.
22. Zheng XM, Wang Y, Pallen CJ. Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature. 1992; 359:336-9.
23. Larsson SC, Orsini N, Wolk A. Vitamin B-6 and Risk of Colorectal Cancer A Meta-analysis of Prospective Studies. Jama-J Am Med Assoc. 2010; 303:1077-83.
24. Ren SG, Melmed S. Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology. 2006; 147:3936-42.
25. Ferreira PA, Ruela-de-Sousa RR, Queiroz KCS, Souza ACS, Milani R, Pilli RA, Peppelenbosch MP, den Hertog J, Ferreira CV. Knocking Down Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) Reverts Chemoresistance through Inactivation of Src and Bcr-Abl Proteins. PLoS One. 2012; 7:e44312.
26. Cordoncardo C, Obrien JP, Boccia J, Casals D, Bertino JR, Melamed MR. Expression of the Multidrug Resistance Gene-Product (P-Glycoprotein) in Human Normal and Tumor-Tissues. J Histochem Cytochem. 1990; 1277-87.
27. Mechetner E, Kyshtoobayeva A, Zonis S, Kim H, Stroup R, Garcia R, Parker RJ, Fruehauf JP. Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin. Clinical Cancer Research. 1998; 389-98.
28. Tomar A, Lim ST, Lim Y, Schlaepfer DD. A FAKp120RasGAP-p190RhoGAP complex regulates polarity in migrating cells (vol 122. pg 1852, 2009). Journal of Cell Science. 2009; 122:1852-62.
29. Sahai E, Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol. 2003; 5:711-9.
30. Morran DC WJ, Jamieson NB, Mrowinska A, Kalna G, Karim SA, Au AY, Scarlett CJ, Chang DK, Pajak MZ, Australian Pancreatic Cancer Genome Initiative (APGI) Oien KA, McKay CJ, Carter CR, Gillen G, Champion S, Pimlott SL, Anderson KI, Evans TR, Grimmond SM, Biankin AV, Sansom OJ, Morton JP. Targeting mTOR dependency in pancreatic cancer. Gut. 2014; 63:1481-9.
31. Khamas A, Ishikawa T, Shimokawa K, Mogushi K, Iida S, Ishiguro M, Mizushima H, Tanaka H, Uetake H, Sugihara K. Screening for Epigenetically Masked Genes in Colorectal Cancer Using 5-Aza-2 '-deoxycytidine, Microarray and Gene Expression Profile. Cancer Genom Proteom. 2012; 9:67-75.
32. Sabates-Beliver J, Van der Flier LG, de Palo M, Cattaneo E, Maake C, Rehrauer H, Laczko E, Kurowski MA, Bujnicki JM, Menigatti M, Luz J, Ranalli TV, Gornes V, Pastorelli A, Faggiani R, Anti M, Jiricny J, Clevers H, Marra G. Transcriptome profile of human colorectal adenomas. Mol Cancer Res. 2007; 5:1263-75.
33. Li Y, de Haar C, Chen M, Deuring J, Gerrits MM, Smits R, Xia B, Kuipers EJ, van der Woude CJ. Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut. 2010; 59:227-35.
34. Bakker ERM, Das AM, Helvensteijn W, Franken PF, Swagemakers S, van der Valk MA, ten Hagen TLM, Kuipers EJ, van Veelen W, Smits R. Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc1638N mice. Carcinogenesis. 2013; 34:2629-38.