메뉴 건너뛰기




Volumn 123, Issue 5, 2015, Pages 365-372

Targeted therapy in gastric cancer

Author keywords

Gastric cancer; HER 2; Targeted therapy; Trastuzumab; VEGFR 2

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MAMMALIAN TARGET OF RAPAMYCIN; RAMUCIRUMAB; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; TRASTUZUMAB; VASCULOTROPIN RECEPTOR 2; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; HGF PROTEIN, HUMAN; MONOCLONAL ANTIBODY; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN;

EID: 84928295481     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12359     Document Type: Review
Times cited : (52)

References (56)
  • 3
    • 84897048556 scopus 로고    scopus 로고
    • Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?
    • Duraes C, Almeida GM, Seruca R, Oliveira C, Carneiro F. Biomarkers for gastric cancer: prognostic, predictive or targets of therapy? Virchows Arch 2014;464:367-78.
    • (2014) Virchows Arch , vol.464 , pp. 367-378
    • Duraes, C.1    Almeida, G.M.2    Seruca, R.3    Oliveira, C.4    Carneiro, F.5
  • 4
    • 85013736066 scopus 로고    scopus 로고
    • Role of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis
    • GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group, Oba K, Paoletti X, Bang YJ, Bleiberg H, Burzykowski T, Fuse N, et al. Role of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis. Eur J Cancer 2013; 49:1565-77.
    • (2013) Eur J Cancer , vol.49 , pp. 1565-1577
    • Oba, K.1    Paoletti, X.2    Bang, Y.J.3    Bleiberg, H.4    Burzykowski, T.5    Fuse, N.6
  • 6
    • 75549083827 scopus 로고    scopus 로고
    • EGFR Signaling and Drug Discovery
    • Lurje G, Lenz HJ. EGFR Signaling and Drug Discovery. Oncology 2009;77:400-10.
    • (2009) Oncology , vol.77 , pp. 400-410
    • Lurje, G.1    Lenz, H.J.2
  • 7
    • 70649098325 scopus 로고    scopus 로고
    • Evolving novel anti-HER2 strategies
    • Jones KL, Buzdar AU. Evolving novel anti-HER2 strategies. Lancet Oncol 2009;10:1179-87.
    • (2009) Lancet Oncol , vol.10 , pp. 1179-1187
    • Jones, K.L.1    Buzdar, A.U.2
  • 8
    • 78249282604 scopus 로고    scopus 로고
    • Genetic and epigenetic alteration in gastric carcinogenesis
    • Resende C, Ristimaki A, Machado JC. Genetic and epigenetic alteration in gastric carcinogenesis. Helicobacter 2010;15(Suppl 1):34-9.
    • (2010) Helicobacter , vol.15 , pp. 34-39
    • Resende, C.1    Ristimaki, A.2    Machado, J.C.3
  • 10
    • 84868630658 scopus 로고    scopus 로고
    • HER2 as a prognostic marker in gastric cancer - A systematic analysis of data from the literature
    • Jorgensen JT, Hersom M. HER2 as a prognostic marker in gastric cancer - A systematic analysis of data from the literature. J Cancer 2012;3:137-44.
    • (2012) J Cancer , vol.3 , pp. 137-144
    • Jorgensen, J.T.1    Hersom, M.2
  • 11
    • 84902318168 scopus 로고    scopus 로고
    • Interpretation of HER2 tests in gastric cancer: confirmation of interobserver differences and validation of a QA/QC educational program
    • Kushima R, Kuwata T, Yao T, Kuriki H, Hashizume K, Masuda S, et al. Interpretation of HER2 tests in gastric cancer: confirmation of interobserver differences and validation of a QA/QC educational program. Virchows Arch 2014;464:539-45.
    • (2014) Virchows Arch , vol.464 , pp. 539-545
    • Kushima, R.1    Kuwata, T.2    Yao, T.3    Kuriki, H.4    Hashizume, K.5    Masuda, S.6
  • 12
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010;376:687-97.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3    Chung, H.C.4    Shen, L.5    Sawaki, A.6
  • 13
    • 84904751533 scopus 로고    scopus 로고
    • Prognostic significance of HER2 expression based on trastuzumab for gastric cancer (ToGA) criteria in gastric cancer: an updated meta-analysis
    • Gu J, Zheng L, Wang Y, Zhu M, Wang Q, Li X. Prognostic significance of HER2 expression based on trastuzumab for gastric cancer (ToGA) criteria in gastric cancer: an updated meta-analysis. Tumour Biol 2014;35:5315-21.
    • (2014) Tumour Biol , vol.35 , pp. 5315-5321
    • Gu, J.1    Zheng, L.2    Wang, Y.3    Zhu, M.4    Wang, Q.5    Li, X.6
  • 14
    • 84928289995 scopus 로고    scopus 로고
    • A study of capecitabine (xeloda) in combination with trastuzumab (herceptin) and oxaliplatine in patients with resectable gastric cancer
    • NLM identifier: NCT01130337. (Accessed 22 May 2014)
    • Hoffmann-La Roche. A study of capecitabine (xeloda) in combination with trastuzumab (herceptin) and oxaliplatine in patients with resectable gastric cancer. In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US). Available at: http://clinicaltrials.gov/show/NCT01130337. NLM identifier: NCT01130337. (Accessed 22 May 2014).
    • In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US)
  • 15
    • 84928289994 scopus 로고    scopus 로고
    • A study of the combination of oxaliplatin, capecitabine and herceptin (trastuzumab) and chemoradiotherapy in the adjuvant setting in operated patients with HER2 + gastric or gastro-esophageal junction cancer (TOXAG study)
    • NLM identifier: NCT01748773. (Accessed 22 May 2014)
    • Hoffmann-La Roche. A study of the combination of oxaliplatin, capecitabine and herceptin (trastuzumab) and chemoradiotherapy in the adjuvant setting in operated patients with HER2 + gastric or gastro-esophageal junction cancer (TOXAG study). In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US). Available at: http://clinicaltrials.gov/show/NCT01748773. NLM identifier: NCT01748773. (Accessed 22 May 2014).
    • In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US)
    • Roche, H.-L.1
  • 16
    • 80054057131 scopus 로고    scopus 로고
    • Southwest oncology group study S0413: a phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer
    • Iqbal S, Goldman B, Fenoglio-Preiser CM, Lenz HJ, Zhang W, Danenberg KD, et al. Southwest oncology group study S0413: a phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer. Ann Oncol 2011;22:2610-5.
    • (2011) Ann Oncol , vol.22 , pp. 2610-2615
    • Iqbal, S.1    Goldman, B.2    Fenoglio-Preiser, C.M.3    Lenz, H.J.4    Zhang, W.5    Danenberg, K.D.6
  • 17
    • 84882418636 scopus 로고    scopus 로고
    • Lapatinib in combination with capecitabine plus oxaliplatin (CapeOx) in HER2-positive advanced or metastatic gastric, esophageal, or gastroesophageal adenocarcinoma (AC): the TRIO-013/LOGiCTrial
    • Abstract
    • Hecht J, Bang Y, Qin S, Chung H, Xu J, Park J, et al. Lapatinib in combination with capecitabine plus oxaliplatin (CapeOx) in HER2-positive advanced or metastatic gastric, esophageal, or gastroesophageal adenocarcinoma (AC): the TRIO-013/LOGiCTrial. J Clin Oncol 2013; 31(Suppl 15):LBA4001. Abstract
    • (2013) J Clin Oncol , vol.31
    • Hecht, J.1    Bang, Y.2    Qin, S.3    Chung, H.4    Xu, J.5    Park, J.6
  • 18
    • 84877605189 scopus 로고    scopus 로고
    • A randomized, open-label, phase III study of lapatinib in combination with paclitaxel versus weekly paclitaxel alone in the second-line treatment of HER2 amplified advanced gastric cancer (AGC) in asian population: tytan study
    • Abstract
    • Bang Y. A randomized, open-label, phase III study of lapatinib in combination with paclitaxel versus weekly paclitaxel alone in the second-line treatment of HER2 amplified advanced gastric cancer (AGC) in asian population: tytan study. J Clin Oncol 2012; 30(Suppl 4):11. Abstract
    • (2012) J Clin Oncol , vol.30 , pp. 11
    • Bang, Y.1
  • 19
    • 84928289986 scopus 로고    scopus 로고
    • A study of perjeta (pertuzumab) in combination with herceptin (trastuzumab) and chemotherapy in patients with HER2 -positive metastatic gastroesophageal junction or gastric cancer
    • NLM identifier: NCT01774786. (Accessed 22 May 2014)
    • Hoffmann-La Roche. A study of perjeta (pertuzumab) in combination with herceptin (trastuzumab) and chemotherapy in patients with HER2 -positive metastatic gastroesophageal junction or gastric cancer. In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US). Available at: http://clinicaltrials.gov/show/NCT01774786. NLM identifier: NCT01774786. (Accessed 22 May 2014).
    • In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US)
    • Roche, H.-L.1
  • 20
    • 84899645435 scopus 로고    scopus 로고
    • Role of human epidermal growth factor receptor 2 in gastric cancer: biological and pharmacological aspects
    • Jorgensen JT. Role of human epidermal growth factor receptor 2 in gastric cancer: biological and pharmacological aspects. World J Gastroenterol 2014;20:4526-35.
    • (2014) World J Gastroenterol , vol.20 , pp. 4526-4535
    • Jorgensen, J.T.1
  • 22
    • 42649133793 scopus 로고    scopus 로고
    • EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number
    • Kim MA, Lee HS, Lee HE, Jeon YK, Yang HK, Kim WH. EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number. Histopathology 2008;52:738-46.
    • (2008) Histopathology , vol.52 , pp. 738-746
    • Kim, M.A.1    Lee, H.S.2    Lee, H.E.3    Jeon, Y.K.4    Yang, H.K.5    Kim, W.H.6
  • 23
    • 80051647503 scopus 로고    scopus 로고
    • Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome
    • Begnami MD, Fukuda E, Fregnani JH, Nonogaki S, Montagnini AL, da Costa WL, et al. Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome. J Clin Oncol 2011;29:3030-6.
    • (2011) J Clin Oncol , vol.29 , pp. 3030-3036
    • Begnami, M.D.1    Fukuda, E.2    Fregnani, J.H.3    Nonogaki, S.4    Montagnini, A.L.5    da Costa, W.L.6
  • 24
    • 84868560972 scopus 로고    scopus 로고
    • Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer
    • Terashima M, Kitada K, Ochiai A, Ichikawa W, Kurahashi I, Sakuramoto S, et al. Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer. Clin Cancer Res 2012;18:5992-6000.
    • (2012) Clin Cancer Res , vol.18 , pp. 5992-6000
    • Terashima, M.1    Kitada, K.2    Ochiai, A.3    Ichikawa, W.4    Kurahashi, I.5    Sakuramoto, S.6
  • 25
    • 84883401358 scopus 로고    scopus 로고
    • Prognostic role of human epidermal growth factor receptor in gastric cancer: a systematic review and meta-analysis
    • Chen C, Yang JM, Hu TT, Xu TJ, Yan G, Hu SL, et al. Prognostic role of human epidermal growth factor receptor in gastric cancer: a systematic review and meta-analysis. Arch Med Res 2013a;44:380-9.
    • (2013) Arch Med Res , vol.44 , pp. 380-389
    • Chen, C.1    Yang, J.M.2    Hu, T.T.3    Xu, T.J.4    Yan, G.5    Hu, S.L.6
  • 26
    • 84876951761 scopus 로고    scopus 로고
    • Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial
    • Lordick F, Kang YK, Chung HC, Salman P, Oh SC, Bodoky G, et al. Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial. Lancet Oncol 2013;14:490-9.
    • (2013) Lancet Oncol , vol.14 , pp. 490-499
    • Lordick, F.1    Kang, Y.K.2    Chung, H.C.3    Salman, P.4    Oh, S.C.5    Bodoky, G.6
  • 27
    • 84876992498 scopus 로고    scopus 로고
    • Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial
    • Waddell T, Chau I, Cunningham D, Gonzalez D, Okines AF, Okines C, et al. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial. Lancet Oncol 2013;14:481-9.
    • (2013) Lancet Oncol , vol.14 , pp. 481-489
    • Waddell, T.1    Chau, I.2    Cunningham, D.3    Gonzalez, D.4    Okines, A.F.5    Okines, C.6
  • 28
    • 33748987894 scopus 로고    scopus 로고
    • Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma
    • Rojo F, Tabernero J, Albanell J, Van Cutsem E, Ohtsu A, Doi T, et al. Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma. J Clin Oncol 2006;24:4309-16.
    • (2006) J Clin Oncol , vol.24 , pp. 4309-4316
    • Rojo, F.1    Tabernero, J.2    Albanell, J.3    Van Cutsem, E.4    Ohtsu, A.5    Doi, T.6
  • 29
    • 77649085714 scopus 로고    scopus 로고
    • A phase II study of perioperative concurrent chemotherapy, gefitinib, and hyperfractionated radiation followed by maintenance gefitinib in locoregionally advanced esophagus and gastroesophageal junction cancer
    • Rodriguez CP, Adelstein DJ, Rice TW, Rybicki LA, Videtic GM, Saxton JP, et al. A phase II study of perioperative concurrent chemotherapy, gefitinib, and hyperfractionated radiation followed by maintenance gefitinib in locoregionally advanced esophagus and gastroesophageal junction cancer. J Thorac Oncol 2010;5:229-35.
    • (2010) J Thorac Oncol , vol.5 , pp. 229-235
    • Rodriguez, C.P.1    Adelstein, D.J.2    Rice, T.W.3    Rybicki, L.A.4    Videtic, G.M.5    Saxton, J.P.6
  • 31
    • 80052439302 scopus 로고    scopus 로고
    • Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction
    • Wainberg ZA, Lin LS, DiCarlo B, Dao KM, Patel R, Park DJ, et al. Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction. Br J Cancer 2011;105:760-5.
    • (2011) Br J Cancer , vol.105 , pp. 760-765
    • Wainberg, Z.A.1    Lin, L.S.2    DiCarlo, B.3    Dao, K.M.4    Patel, R.5    Park, D.J.6
  • 32
    • 0036252329 scopus 로고    scopus 로고
    • Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model
    • Jung YD, Mansfield PF, Akagi M, Takeda A, Liu W, Bucana CD, et al. Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model. Eur J Cancer 2002;38:1133-40.
    • (2002) Eur J Cancer , vol.38 , pp. 1133-1140
    • Jung, Y.D.1    Mansfield, P.F.2    Akagi, M.3    Takeda, A.4    Liu, W.5    Bucana, C.D.6
  • 33
    • 84876378081 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of galectin-1 and vascular endothelial growth factor expression in gastric cancer
    • Chen J, Zhou SJ, Zhang Y, Zhang GQ, Zha TZ, Feng YZ, et al. Clinicopathological and prognostic significance of galectin-1 and vascular endothelial growth factor expression in gastric cancer. World J Gastroenterol 2013b;19:2073-9.
    • (2013) World J Gastroenterol , vol.19 , pp. 2073-2079
    • Chen, J.1    Zhou, S.J.2    Zhang, Y.3    Zhang, G.Q.4    Zha, T.Z.5    Feng, Y.Z.6
  • 34
    • 77649213706 scopus 로고    scopus 로고
    • Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin JL, Cohen RB, Eadens M, Gore L, Camidge DR, Diab S, et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 2010;28:780-7.
    • (2010) J Clin Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3    Gore, L.4    Camidge, D.R.5    Diab, S.6
  • 35
    • 84892852372 scopus 로고    scopus 로고
    • Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial
    • Fuchs CS, Tomasek J, Yong CJ, Dumitru F, Passalacqua R, Goswami C, et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 2014;383:31-9.
    • (2014) Lancet , vol.383 , pp. 31-39
    • Fuchs, C.S.1    Tomasek, J.2    Yong, C.J.3    Dumitru, F.4    Passalacqua, R.5    Goswami, C.6
  • 36
    • 84893395110 scopus 로고    scopus 로고
    • RAINBOW: a global, phase III, randomized, double-blind study of ramucirumab plus paclitaxel versus placebo plus paclitacel in the treamtent of metastatic gastroesophageal junction (GEJ) and gastric adenocarcinoma following disease progression on first-line platinum-and fluoropyrymidine-containing combination therapy rainbow IMCL CP12-0922 (I4T-IE-JVBE)
    • Abstract
    • Wilke H, Van Cutsem E, Oh SC, Bodoky G, Shimada Y, Hironaka S, et al. RAINBOW: a global, phase III, randomized, double-blind study of ramucirumab plus paclitaxel versus placebo plus paclitacel in the treamtent of metastatic gastroesophageal junction (GEJ) and gastric adenocarcinoma following disease progression on first-line platinum-and fluoropyrymidine-containing combination therapy rainbow IMCL CP12-0922 (I4T-IE-JVBE). J Clin Oncol 2014; 32(Suppl 3):LBA7. Abstract
    • (2014) J Clin Oncol , vol.32
    • Wilke, H.1    Van Cutsem, E.2    Oh, S.C.3    Bodoky, G.4    Shimada, Y.5    Hironaka, S.6
  • 37
    • 84928289984 scopus 로고    scopus 로고
    • A study of ramucirumab in patients with gastric, esophageal and gastroesophageal cancer
    • NLM identifier: NCT01246960. (Accessed 26 May 2014)
    • Eli Lilly and Company. A study of ramucirumab in patients with gastric, esophageal and gastroesophageal cancer. In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US). Available at: http://clinicaltrials.gov/show/NCT01246960. NLM identifier: NCT01246960. (Accessed 26 May 2014).
    • In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US)
  • 38
    • 84891373220 scopus 로고    scopus 로고
    • Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial
    • Li J, Qin S, Xu J, Guo W, Xiong J, Bai Y, et al. Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial. J Clin Oncol 2013;31:3219-25.
    • (2013) J Clin Oncol , vol.31 , pp. 3219-3225
    • Li, J.1    Qin, S.2    Xu, J.3    Guo, W.4    Xiong, J.5    Bai, Y.6
  • 39
    • 80053573446 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study
    • Ohtsu A, Shah MA, Van Cutsem E, Rha SY, Sawaki A, Park SR, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study. J Clin Oncol 2011;29:3968-76.
    • (2011) J Clin Oncol , vol.29 , pp. 3968-3976
    • Ohtsu, A.1    Shah, M.A.2    Van Cutsem, E.3    Rha, S.Y.4    Sawaki, A.5    Park, S.R.6
  • 40
    • 84863897798 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial
    • Van Cutsem E, de Haas S, Kang YK, Ohtsu A, Tebbutt NC, Ming XJ, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial. J Clin Oncol 2012;30:2119-27.
    • (2012) J Clin Oncol , vol.30 , pp. 2119-2127
    • Van Cutsem, E.1    de Haas, S.2    Kang, Y.K.3    Ohtsu, A.4    Tebbutt, N.C.5    Ming, X.J.6
  • 41
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: a target for cancer therapy
    • Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004;4:335-48.
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 42
    • 52149087173 scopus 로고    scopus 로고
    • Everolimus (RAD001) and anti-angiogenic cyclophosphamide show long-term control of gastric cancer growth in vivo
    • Cejka D, Preusser M, Woehrer A, Sieghart W, Strommer S, Werzowa J, et al. Everolimus (RAD001) and anti-angiogenic cyclophosphamide show long-term control of gastric cancer growth in vivo. Cancer Biol Ther 2008;7:1377-85.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1377-1385
    • Cejka, D.1    Preusser, M.2    Woehrer, A.3    Sieghart, W.4    Strommer, S.5    Werzowa, J.6
  • 44
    • 74949131430 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of RAD001 (everolimus) administered daily to Japanese patients with advanced solid tumors
    • Okamoto I, Doi T, Ohtsu A, Miyazaki M, Tsuya A, Kurei K, et al. Phase I clinical and pharmacokinetic study of RAD001 (everolimus) administered daily to Japanese patients with advanced solid tumors. Jpn J Clin Oncol 2010;40:17-23.
    • (2010) Jpn J Clin Oncol , vol.40 , pp. 17-23
    • Okamoto, I.1    Doi, T.2    Ohtsu, A.3    Miyazaki, M.4    Tsuya, A.5    Kurei, K.6
  • 45
    • 77951635629 scopus 로고    scopus 로고
    • Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer
    • Doi T, Muro K, Boku N, Yamada Y, Nishina T, Takiuchi H, et al. Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer. J Clin Oncol 2010;28:1904-10.
    • (2010) J Clin Oncol , vol.28 , pp. 1904-1910
    • Doi, T.1    Muro, K.2    Boku, N.3    Yamada, Y.4    Nishina, T.5    Takiuchi, H.6
  • 46
    • 84891371392 scopus 로고    scopus 로고
    • Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study
    • Ohtsu A, Ajani JA, Bai YX, Bang YJ, Chung HC, Pan HM, et al. Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study. J Clin Oncol 2013;31:3935-43.
    • (2013) J Clin Oncol , vol.31 , pp. 3935-3943
    • Ohtsu, A.1    Ajani, J.A.2    Bai, Y.X.3    Bang, Y.J.4    Chung, H.C.5    Pan, H.M.6
  • 47
    • 84928289982 scopus 로고    scopus 로고
    • A randomized, double blind study evaluationg paclitaxel with and without RAD001 in patients with gastric adenocarcinoma after prior chemotherapy (AIO-STO-0111)
    • NLM identifier: NCT01248403. (Accessed 26 May 2014)
    • Al-Batran SE. A randomized, double blind study evaluationg paclitaxel with and without RAD001 in patients with gastric adenocarcinoma after prior chemotherapy (AIO-STO-0111). In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US). Available at: http://clinicaltrials.gov/show/NCT01248403. NLM identifier: NCT01248403. (Accessed 26 May 2014).
    • In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US)
    • Al-Batran, S.E.1
  • 49
    • 84861733799 scopus 로고    scopus 로고
    • MET: a promising anticancer therapeutic target
    • Peters S, Adjei AA. MET: a promising anticancer therapeutic target. Nat Rev Clin Oncol 2012;9:314-26.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 314-326
    • Peters, S.1    Adjei, A.A.2
  • 50
    • 84892394160 scopus 로고    scopus 로고
    • C-met as a prognostic marker in gastric cancer: a systematic review and meta-analysis
    • Yu S, Yu Y, Zhao N, Cui J, Li W, Liu T. C-met as a prognostic marker in gastric cancer: a systematic review and meta-analysis. PLoS ONE 2013;8:e79137.
    • (2013) PLoS ONE , vol.8
    • Yu, S.1    Yu, Y.2    Zhao, N.3    Cui, J.4    Li, W.5    Liu, T.6
  • 51
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • Lennerz JK, Kwak EL, Ackerman A, Michael M, Fox SB, Bergethon K, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol 2011;29:4803-10.
    • (2011) J Clin Oncol , vol.29 , pp. 4803-4810
    • Lennerz, J.K.1    Kwak, E.L.2    Ackerman, A.3    Michael, M.4    Fox, S.B.5    Bergethon, K.6
  • 52
    • 84928289981 scopus 로고    scopus 로고
    • Phase 2 study assessing efficacy and safety of crizotinib in patients harboring an alteration on ALK, MET or ROS1 (AcSé)
    • NLM identifier: NCT02034981. (Accessed 28 May 2014)
    • Unicancer. Phase 2 study assessing efficacy and safety of crizotinib in patients harboring an alteration on ALK, MET or ROS1 (AcSé). In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US). Available at: http://clinicaltrials.gov/show/NCT02034981. NLM identifier: NCT02034981. (Accessed 28 May 2014).
    • In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US)
  • 53
    • 84870511276 scopus 로고    scopus 로고
    • Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer
    • Abstract
    • Oliner KS, Tang R, Aderson A, Lan Y, Iveson T, Donehower R.C., et al. Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer. J Clin Oncol 2012; 30(Suppl 15):4005. Abstract
    • (2012) J Clin Oncol , vol.30 , pp. 4005
    • Oliner, K.S.1    Tang, R.2    Aderson, A.3    Lan, Y.4    Iveson, T.5    Donehower, R.C.6
  • 54
    • 84901673031 scopus 로고    scopus 로고
    • RILOMET-1: an international phase III multicenter, randomized, double-blind, placebo-controlled trial of rilotumumab plus epirubicin, cisplatin, and capecitabine (ECX) as first-line therapy in patients with advanced MET-postive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma
    • Abstract
    • Cunningham D, Al-Batran SE, Davidenko I, Ilson DH, Murad AM, Tebbutt NC, et al. RILOMET-1: an international phase III multicenter, randomized, double-blind, placebo-controlled trial of rilotumumab plus epirubicin, cisplatin, and capecitabine (ECX) as first-line therapy in patients with advanced MET-postive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma. J Clin Oncol 2013a;31(Suppl 15):TPS4153. Abstract
    • (2013) J Clin Oncol , vol.31
    • Cunningham, D.1    Al-Batran, S.E.2    Davidenko, I.3    Ilson, D.H.4    Murad, A.M.5    Tebbutt, N.C.6
  • 55
    • 84928289980 scopus 로고    scopus 로고
    • A phase 3 study of rilotumumab (AMG 102) with cisplation and capecitabine (CX) as first-line therapy in gastric cancer (RILOMET-2)
    • NLM identifier: NCT02137343. (Accessed 28 May 2014)
    • Amgen. A phase 3 study of rilotumumab (AMG 102) with cisplation and capecitabine (CX) as first-line therapy in gastric cancer (RILOMET-2). In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US). Available at: http://clinicaltrials.gov/show/NCT02137343. NLM identifier: NCT02137343. (Accessed 28 May 2014).
    • In: ClincalTrials.gov. Bethesda, MD: National library of medicine (US)
  • 56
    • 84902084207 scopus 로고    scopus 로고
    • MetGastric: a randomized phase III study of onartuzumab (MetMAb) in combination with mFOLFOX6 in patients with metastatic HER2-negative and MET-positive adenocarcinoma of the stomach or gastroesophageal juntion
    • Abstract
    • Cunningham D, Bang YJ, Tabernero J, Shah MA, Lordick F, Hack SP. MetGastric: a randomized phase III study of onartuzumab (MetMAb) in combination with mFOLFOX6 in patients with metastatic HER2-negative and MET-positive adenocarcinoma of the stomach or gastroesophageal juntion. J Clin Oncol 2013b; 31(Suppl 15):TPS4155. Abstract
    • (2013) J Clin Oncol , vol.31
    • Cunningham, D.1    Bang, Y.J.2    Tabernero, J.3    Shah, M.A.4    Lordick, F.5    Hack, S.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.