The overlapping of the spectra: Overlapping genes and genetic models

The Overlap of Affective and Schizophrenic Spectra

Volumn 9780521858588, Issue , 2006, Pages 25-42

  Kelsoe, John R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENETIC ENGINEERING;

CLINICAL PRESENTATIONS; GENETIC MECHANISM; GENETIC RELATIONSHIPS; GENETIC SUSCEPTIBILITY; MOLECULAR GENETICS; OVERLAPPING GENES; PATHOPHYSIOLOGICAL; SUSCEPTIBILITY GENES;

GENES;

EID: 84928271754     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511544040.003     Document Type: Chapter

References (72)

1. Andreasen, N. C., Rice, J., Endicott, J. et al.(1987). Familial rates of affective disorder. A report from the National Institute of Mental Health Collaborative Study. Archives of General Psychiatry, 44, 461–9.
2. Badner, J. A. and Gershon, E. S. (2002). Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Molecular Psychiatry, 7(4), 405–11.
3. Barrett, T. B., Hauger, R. L. and Kennedy, J. L. (2003). Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Molecular Psychiatry, 8, 546–57.
4. Berrettini, W. H. (2000). Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia. Biological Psychiatry, 47(3), 245–51.
5. Bienvenu, T., Beldjord, C., Adjiman, M. and Kaplan, J. C. (1993). Male infertility as the only presenting sign of cystic fibrosis when homozygous for the mild mutation R117H. Journal of Medical Genetics, 30(9), 797.
6. Blackwood, D. H., Fordyce, A., Walker, M. T. et al.(2001). Schizophrenia and affective disorders–cosegregation with a translocation at chromosome 1q42 that directly disrupts brainexpressed genes: clinical and P300 findings in a family. American Journal of Human Genetics, 69(2), 428–33.
7. Blackwood, D. H. and Muir, W. J. (2004). Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia. Neurotoxicity Research, 6(1), 35–41.
8. Blouin, J. L., Dombroski, B. A., Nath, S. K. et al.(1998). Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nature Genetics, 20, 70–3.
9. Bray, N. J., Buckland, P. R., Williams, N. M. et al.(2003). A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. American Journal of Human Genetics, 73(1), 152–61.
10. Cardno, A. G., Rijsdijk, F. V., Sham, P. C., Murray, R. M. and McGuffin, P. (2002). A twin study of genetic relationships between psychotic symptoms. American Journal of Psychiatry, 159(4), 539–45.
11. Chen, J., Lipska, B. K., Halim, N. et al.(2004a). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics, 75(5), 807–21.
12. Chen, X., Dunham, C., Kendler, S. et al.(2004b). Regulator of G-protein signaling 4 (RGS4) gene is associated with schizophrenia in Irish high density families. American Journal of Medical Genetics, 129B(1), 23–6.
13. Chen, Y. S., Akula, N., Detera-Wadleigh, S. D. et al.(2004c). Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. Molecular Psychiatry, 9(1), 87–92.
14. Chowdari, K. V., Mirnics, K., Semwal, P. et al.(2002). Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Human Molecular Genetics, 11(12), 1373–80.
15. Chumakov, I., Blumenfeld, M., Guerassimenko, O. et al.(2002). Genetic and physiological data implicating the new human gene G72 and the gene for D-amino-acid oxidase in schizophrenia. Proceedings of the National Academy of Sciences USA, 99(21), 13675–80.
16. Corfas, G., Roy, K. and Buxbaum, J. D. (2004). Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nature Neuroscience, 7(6), 575–80.
17. Detera-Wadleigh, S. D., Badner, J. A., Berrettini, W. H. (1999). A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proceedings of the National Academy of Sciences USA, 96(10), 5604–9.
18. Egan, M. F., Goldberg, T. E., Kolachana, B. S. et al.(2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences USA, 98(12), 6917–22.
19. Erlenmeyer-Kimling, L., Adamo, U. H., Rock, D. et al.(1997). The New York High-Risk Project. Prevalence and comorbidity of axis I disorders in offspring of schizophrenic parents at 25-year follow-up. Archives of General Psychiatry, 54, 1096–102.
20. Gainetdinov, R. R., Premont, R. T., Bohn, L. M., Lefkowitz, R. J. and Caron, M. G. (2004). Desensitization of G protein-coupled receptors and neuronal functions. Annual Review of Neuroscience, 27, 107–44.
21. Gershon, E. S., Hamovit, J., Guroff, J. J. et al.(1982). A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Archives of General Psychiatry, 39, 1157–67.
22. Green, E. K., Raybould, R., Macgregor, S. et al.(2004). Evidence that variation at the neuregulin gene (NRG1) influences susceptibility to bipolar disorder with maximal effect in individuals who experience mania and mood-incongruent psychotic features. American Journal ofMedical Genetics, 130B, 27.
23. Hattori, E., Liu, C., Badner, J. A. et al.(2003). Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. American Journal of Human Genetics, 72(5), 1131–40.
24. Hennah, W., Varilo, T., Kestila, M. et al.(2003). Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Human Molecular Genetics, 12(23), 3151–9.
25. Hodgkinson, C. A., Goldman, D., Jaeger, J. et al.(2004). Disrupted in schizophrenia 1 (DISC1): Association with schizophrenia, schizoaffective disorder, and bipolar disorder. American Journal of Human Genetics, 75(5), 862–72.
26. Husi, H., Ward, M. A., Choudhary, J. S., Blackstock, W. P. and Grant, S. G. (2000). Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nature Neuroscience, 3(7), 661–9.
27. Inoue, A. and Okabe, S. (2003). The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function. Current Opinion in Neurobiology, 13(3), 332–40.
28. Kelsoe, J. R. (1999). Recent progress in the search for genes for bipolar disorder. Current Psychiatry Reports, 1(2), 135–40.
29. Kelsoe, J. R., Spence, M. A., Loetscher, E. et al.(2001). A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proceedings of the National Academy of Sciences USA, 98(2), 585–90.
30. Kendler, K. S., Karkowski, L. M. and Walsh, D. (1998). The structure of psychosis: latent class analysis of probands from the Roscommon Family Study. Archives of General Psychiatry, 55, 492–9.
31. Kockelkorn, T. T., Arai, M., Matsumoto, H. et al.(2004). Association study of polymorphisms in the 5’ upstream region of human DISC1 gene with schizophrenia. Neuroscience Letters, 368(1), 41–5.
32. Kohn, Y., Danilovich, E., Filon, D. et al.(2004). Linkage disequlibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: findings from identity by descent haplotype sharing analysis. American Journal of Medical Genetics, 128B(1), 65–70.
33. Lachman, H. M., Morrow, B., Shprintzen, R. et al.(1996a). Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. American Journal of Medical Genetics, 67, 468–72.
34. Lachman, H. M., Papolos, D. F., Saito, T. et al.(1996b). Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 243–50.
35. Lander, E. and Kruglyak, L. (1995). Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics, 11, 241–7.
36. Levinson, D. F., Levinson, M. D., Segurado, R. and Lewis, C. M. (2003). Genome scan meta analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis. American Journal of Human Genetics, 73(1), 17–33.
37. Lewis, C. M., Levinson, D. F., Wise, L. H. et al.(2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. American Journal of Human Genetics, 73(1), 34–48.
38. Li, T. Sham, P. C., Vallada, H. et al.(1996). Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatric Genetics, 6(3), 131–3.
39. Lotta, T., Vidgren, J., Tilgmann, C. et al.(1995). Kinetics of human soluble and membrane bound catechol O-methyl transferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 34(13), 4202–10.
40. Mathews, C. A. and Reus, V. I. (2003). Genetic linkage in bipolar disorder. CNS Spectrums, 8(12), 891–904.
41. Millar, J. K., Christie, S., Anderson, S. et al.(2001). Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia. Molecular Psychiatry, 6(2), 173–8.
42. Millar, J. K., Christie, S. and Porteous, D. J. (2003). Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochemical and Biophysical Research Communications, 311(4), 1019–25.
43. Millar, J. K., James, R., Brandon, N. J. and Thomson, P. A. (2004). DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. Annals of Medicine, 36(5), 367–78.
44. Mirnics, K., Middleton, F. A., Stanwood, G. D., Lewis, D. A. and Levitt, P. (2001). Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Molecular Psychiatry, 6(3), 293–301.
45. Moises, H. W., Zoega, T. and Gottesman, I. I. (2002). The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia. BMC Psychiatry, 2(1), 8.
46. Morris, D. W., Rodgers, A., McGhee, K. A. et al.(2004). Confirming RGS4 as a susceptibility gene for schizophrenia. American Journal of Medical Genetics, 125B(1), 50–3.
47. Morris, J. A., Kandpal, G., Ma, L. and Austin, C. P. (2003). DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Human Molecular Genetics, 12(13), 1591–1608.
48. Myles-Worsley, M., Coon, H., McDowell, J. et al.(1999). Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. American Journal of Medical Genetics, 88(5), 544–50.
49. Niculescu, A. B. 3rd, Segal, D. S., Kuczenski, R. et al.(2000). Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiological Genomics, 4(1), 83–91.
50. Numakawa, T., Yagasaki, Y., Ishimoto, T. et al.(2004). Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Human Molecular Genetics, 13(21), 2699–708.
51. Papolos, D. F., Veit, S., Faedda, G. L., Saito, T. and Lachman, H. M. (1998). Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele. Molecular Psychiatry, 3, 346–9.
52. Potash, J. B., Willour, V. L., Chiu, Y. F. et al.(2001). The familial aggregation of psychotic symptoms in bipolar disorder pedigrees. American Journal of Psychiatry, 158(8), 1258–64.
53. Potash, J. B., Zandi, P. P., Willour, V. L. et al.(2003). Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder. American Journal of Psychiatry, 160(4), 680–6.
54. Prathikanti, S. and McMahon, F. J. (2001). Genome scans for susceptibility genes in bipolar affective disorder. Annals of Medicine, 33(4), 257–62.
55. Pulver, A. E., Karayiorgou, M., Wolyniec, P. S. et al.(1994). Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12–q13.1: Part 1. American Journal of Medical Genetics, 54, 36–43.
56. Rotondo, A., Mazzanti, C., Dell’Osso, L. et al.(2002). Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. American Journal of Psychiatry, 159(1), 23–9.
57. Schurov, I. L., Handford, E. J., Brandon, N. J. and Whiting, P. J. (2004). Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Molecular Psychiatry, 9(12), 1100–10.
58. Schwab, S. G., Hallmayer, J., Lerer, B. et al.(1998). Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. American Journal of Human Genetics, 63, 1139–52.
59. Segurado, R., Detera-Wadleigh, S. D., Levinson, D. F. et al.(2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. American Journal of Human Genetics, 73(1), 49–62.
60. Shaw, S. H., Mroczkowski-Parker, Z., Shekhtman, T. et al.(2003). Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series. Molecular Psychiatry, 8(5), 558–64.
61. Shifman, S., Bronstein, M., Sternfeld, M. et al.(2002). A highly significant association between a COMT haplotype and schizophrenia. American Journal of Human Genetics, 71(6), 1296–302.
62. Stefansson, H., Sarginson, J., Kong, A. et al.(2003). Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. American Journal ofHuman Genetics, 72(1), 83–7.
63. Stefansson, H., Sigurdsson, E., Steinthorsdottir, V. et al.(2002). Neuregulin 1 and susceptibility to schizophrenia. American Journal of Human Genetics, 71(4), 877–92.
64. Straub, R. E., Jiang, Y., MacLean, C. J. et al.(2002). Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. American Journal of Human Genetics, 71(2), 337–48.
65. Straub, R. E., MacLean, C. J., O’Neill, F. A. et al.(1995). A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity. Nature Genetics, 11, 287–93.
66. Tsuang, M. T., Winokur, G. and Crowe, R. R. (1980). Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry, 137, 497–504.
67. Viskochil, D. (2002). Genetics of neurofibromatosis 1 and the NF1 gene. Journal of Child Neurology, 17(8), 562–70.
68. Weissman, M. M., Gershon, E. S., Kidd, K. K. et al.(1984). Psychiatric disorders in the relatives of probands with affective disorders. The Yale University–National Institute of Mental Health Collaborative Study. Archives of General Psychiatry, 41, 13–21.
69. Williams, N. M., Preece, A., Spurlock, G. et al.(2004). Support for RGS4 as a susceptibility gene for schizophrenia. Biological Psychiatry, 55(2), 192–5.
70. Yang, J. Z., Si, T. M., Ruan, Y. et al.(2003). Association study of neuregulin 1 gene with schizophrenia. Molecular Psychiatry, 8(7), 706–9.
71. Yu, S. Y., Takahashi, S., Arinami, T. et al.(2004). Mutation screening and association study of the betaadrenergic receptor kinase 2 gene in schizophrenia families. Psychiatry Research, 125(2), 95–104.
72. Zill, P., Baghai, T. C., Engel, R., Zwanzger, P. et al.(2004). The dysbindin gene in major depression: an association study. American Journal of Medical Genetics, 129B(1), 55–8.