TIMP-1 inhibition of occludin degradation in Caco-2 intestinal cells: A potential protective role in necrotizing enterocolitis

Pediatric Research

Volumn 77, Issue 5, 2015, Pages 649-655

  Bein, Amir ^a   Lubetzky, Ronit ^b,c   Mandel, Dror ^b,c   Schwartz, Betty ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN 4; GELATINASE A; OCCLUDIN; RECOMBINANT PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; MMP2 PROTEIN, HUMAN; OCLN PROTEIN, HUMAN; TIMP1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BREAST MILK; CACO 2 CELL LINE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; INTESTINE MUCOSA PERMEABILITY; NECROTIZING ENTEROCOLITIS; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTECTION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; THEORETICAL MODEL; TIGHT JUNCTION; ZYMOGRAPHY; GENE EXPRESSION REGULATION; INTESTINE; METABOLISM; PATHOLOGY; PERMEABILITY;

CACO-2 CELLS; ENTEROCOLITIS, NECROTIZING; GENE EXPRESSION REGULATION; HUMANS; INTESTINES; MATRIX METALLOPROTEINASE 2; MILK, HUMAN; OCCLUDIN; PERMEABILITY; RECOMBINANT PROTEINS; TIGHT JUNCTIONS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84928243569     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2015.26     Document Type: Article

References (28)

1. Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med 2011;364: 255-64.
2. Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet 2006;368:1271-83.
3. Schnabl KL, Van Aerde JE, Thomson AB, Clandinin MT. Necrotizing enterocolitis: a multifactorial disease with no cure. World J Gastroenterol 2008;14:2142-61.
4. Petty JK, Ziegler MM. Operative strategies for necrotizing enterocolitis: The prevention and treatment of short-bowel syndrome. Semin Pediatr Surg 2005;14:191-8.
5. Sullivan S, Schanler RJ, Kim JH, et al. An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products. J Pediatr 2010;156:562-7.e1.
6. Lucas A, Cole TJ. Breast milk and neonatal necrotising enterocolitis. Lancet 1990;336:1519-23.
7. Quigley M. A, Henderson G, Anthony MY, McGuire W. Formula milk versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev 2007:CD002971.
8. Meinzen-Derr J, Poindexter B, Wrage L, Morrow AL, Stoll B, Donovan EF. Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death. J Perinatol 2009;29:57-62.
9. Martin CR, Walker WA. Intestinal immune defences and the inflammatory response in necrotising enterocolitis. Semin Fetal Neonatal Med 2006;11:369-77.
10. Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta 2008;1778:660-9.
11. Lubetzky R, Mandel D, Mimouni FB, Herman L, Reich R, Reif S. MMP-2 and MMP-9 and their tissue inhibitor in preterm human milk. J Pediatr Gastroenterol Nutr 2010;51:210-2.
12. Sim WH, Wagner J, Cameron DJ, Catto-Smith AG, Bishop RF, Kirkwood CD. Expression profile of genes involved in pathogenesis of pediatric Crohn's disease. J Gastroenterol Hepatol 2012;27:1083-93.
13. Baugh MD, Perry MJ, Hollander AP, et al. Matrix metalloproteinase levels are elevated in inflammatory bowel disease. Gastroenterology 1999;117:814-22.
14. Stallmach A, Chan CC, Ecker KW, et al. Comparable expression of matrix metalloproteinases 1 and 2 in pouchitis and ulcerative colitis. Gut 2000;47:415-22.
15. Pender SL, Braegger C, Gunther U, et al. Matrix metalloproteinases in necrotising enterocolitis. Pediatr Res 2003;54:160-4.
16. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003;92:827-39.
17. Medina C, Radomski MW. Role of matrix metalloproteinases in intestinal inflammation. J Pharmacol Exp Ther 2006;318:933-8.
18. Bister V, Salmela MT, Heikkilä P, et al. Matrilysins-1 and-2 (MMP-7 and-26) and metalloelastase (MMP-12), unlike MMP-19, are up-regulated in necrotizing enterocolitis. J Pediatr Gastroenterol Nutr 2005;40:60-6.
19. Feldman GJ, Mullin JM, Ryan MP. Occludin: structure, function and regulation. Adv Drug Deliv Rev 2005;57:883-917.
20. Ritter LM, Garfield SH, Thorgeirsson UP. Tissue inhibitor of metalloproteinases-1 (TIMP-1) binds to the cell surface and translocates to the nucleus of human MCF-7 breast carcinoma cells. Biochem Biophys Res Commun 1999;257:494-9.
21. Frost BL, Caplan MS. Necrotizing enterocolitis: pathophysiology, plateletactivating factor, and probiotics. Semin Pediatr Surg 2013;22:88-93.
22. Alfaleh K, Anabrees J, Bassler D, Al-Kharfi T. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2011 16;(3):CD005496.
23. Olson MW, Gervasi DC, Mobashery S, Fridman R. Kinetic analysis of the binding of human matrix metalloproteinase-2 and-9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. J Biol Chem 1997;272: 29975-83.
24. Verstappen J, Von den Hoff JW. Tissue inhibitors of metalloproteinases (TIMPs): their biological functions and involvement in oral disease. J Dent Res 2006;85:1074-84.
25. Zhao WQ, Li H, Yamashita K, et al. Cell cycle-associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts. J Cell Sci 1998;111 (Pt 9):1147-53.
26. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-19.
27. Wachtel M, Frei K, Ehler E, Fontana A, Winterhalter K, Gloor SM. Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition. J Cell Sci 1999;112 (Pt 23): 4347-56.
28. Liu J, Jin X, Liu KJ, Liu W. Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. J Neurosci 2012;32:3044-57.