A rare 8q24 single nucleotide polymorphism (SNP) predisposes North American men to prostate cancer and possibly more aggressive disease

BJU International

Volumn 115, Issue 1, 2015, Pages 101-105

  Grin, Boris ^a   Loeb, Stacy ^c   Roehl, Kim ^a   Cooper, Phillip R ^a   Catalona, William J ^a   Helfand, Brian T ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

genetics; polymorphism; prostatic neoplasm; single nucleotide

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AFRICAN AMERICAN; AGE DISTRIBUTION; AGED; ANTIGEN DETECTION; ARTICLE; CASE CONTROL STUDY; CAUCASIAN; COHORT ANALYSIS; CONTROLLED STUDY; GENE FREQUENCY; GENE LOCUS; GENE SEQUENCE; GLEASON SCORE; HISPANIC; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; PROSTATECTOMY; RACE DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE; TUMOR SUPPRESSOR GENE; ALLELE; CHROMOSOME 8; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PROSTATIC NEOPLASMS; SURVIVAL ANALYSIS; UNITED STATES;

AGED; ALLELES; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 8; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC NEOPLASMS; SURVIVAL ANALYSIS; UNITED STATES;

EID: 84928238386     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/bju.12847     Document Type: Article

References (12)

1. Siegel R, Naishadham D, Jemal A,. Cancer statistics, 2013. CA Cancer J Clin 2013; 63: 11-30
2. Kim ST, Cheng Y, Hsu FC, et al. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. Prostate 2010; 70: 1729-1738
3. Eeles RA, Olama AA, Benlloch S, et al. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet 2013; 45: 385-391
4. Liu H, Wang B, Han C,. Meta-analysis of genome-wide and replication association studies on prostate cancer. Prostate 2011; 71: 209-224
5. Gudmundsson J, Sulem P, Manolescu A, et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet 2007; 39: 631-637
6. Zheng SL, Sun J, Wiklund F, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med 2008; 358: 910-919
7. Haiman CA, Patterson N, Freedman ML, et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet 2007; 39: 638-644
8. Ishak MB, Giri VN,. A systematic review of replication studies of prostate cancer susceptibility genetic variants in high-risk men originally identified from genome-wide association studies. Cancer Epidemiol Biomarkers Prev 2011; 20: 1599-1610
9. Hidorff LA, MacArthur J, Morales J, et al. Catalog of published genome-wide association studies. genome.gov. Available at: http://www.genome.gov/gwastudies/. Accessed June 2013
10. Gudmundsson J, Sulem P, Gudbjartsson DF, et al. A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer. Nat Genet 2012; 44: 1326-1329
11. Ewing CM, Ray AM, Lange EM, et al. Germline mutations in HOXB13 and prostate-cancer risk. N Engl J Med 2012; 366: 141-149
12. Gudmundsson J, Sulem P, Steinthorsdottir V, et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 2007; 39: 977-983