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Volumn 93, Issue 4, 2015, Pages 321-322

Boosting regulatory T-cell function with the humanized CD4-specific humanized monoclonal antibody Tregalizumab (BT-061)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIBODY; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; METHOTREXATE; OKT 3; TRANSCRIPTION FACTOR FOXP3; TREGALIZUMAB; EPITOPE; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY;

EID: 84928208498     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2014.120     Document Type: Note
Times cited : (3)

References (14)
  • 1
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012; 30: 531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 2
    • 84896704750 scopus 로고    scopus 로고
    • Homeostatic control of regulatory T cell diversity
    • Liston A, Gray DH. Homeostatic control of regulatory T cell diversity. Nature Reviews Immunol 2014; 14: 154-165.
    • (2014) Nature Reviews Immunol , vol.14 , pp. 154-165
    • Liston, A.1    Gray, D.H.2
  • 3
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 4
    • 84908089142 scopus 로고    scopus 로고
    • TREG-cell therapies for autoimmune rheumatic diseases
    • Miyara M, Ito Y, Sakaguchi S. TREG-cell therapies for autoimmune rheumatic diseases. Nat Rev Rheumatol 2014; 10: 543-551.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 543-551
    • Miyara, M.1    Ito, Y.2    Sakaguchi, S.3
  • 5
    • 82555196118 scopus 로고    scopus 로고
    • Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
    • Saadoun D, Rosenzwajg M, Joly F, Six A, Carrat F, Thibault V et al. Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. New England J Med 2011; 365: 2067-2077.
    • (2011) New England J Med , vol.365 , pp. 2067-2077
    • Saadoun, D.1    Rosenzwajg, M.2    Joly, F.3    Six, A.4    Carrat, F.5    Thibault, V.6
  • 6
    • 84904470709 scopus 로고    scopus 로고
    • Current issues in chronic graft-versus-host disease
    • Socie G, Ritz J. Current issues in chronic graft-versus-host disease. Blood 2014; 124: 374-384.
    • (2014) Blood , vol.124 , pp. 374-384
    • Socie, G.1    Ritz, J.2
  • 7
    • 84876012054 scopus 로고    scopus 로고
    • Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
    • Matsuoka K, Koreth J, Kim HT, Bascug G, McDonough S, Kawano Y et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med 2013; 5: 179ra43.
    • (2013) Sci Transl Med , vol.5 , pp. 179-243
    • Matsuoka, K.1    Koreth, J.2    Kim, H.T.3    Bascug, G.4    McDonough, S.5    Kawano, Y.6
  • 8
    • 84904899365 scopus 로고    scopus 로고
    • HLA-haploidentical transplantation with regulatory and conventional T cell adoptive immunotherapy prevents acute leukemia relapse
    • Martelli MF, Di Ianni M, Ruggeri L, Falzetti F, Carotti A, Terenzi A et al. HLA-haploidentical transplantation with regulatory and conventional T cell adoptive immunotherapy prevents acute leukemia relapse. Blood 2014; 124: 638-644.
    • (2014) Blood , vol.124 , pp. 638-644
    • Martelli, M.F.1    Di Ianni, M.2    Ruggeri, L.3    Falzetti, F.4    Carotti, A.5    Terenzi, A.6
  • 9
    • 84899144218 scopus 로고    scopus 로고
    • Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets-results of one year follow-up
    • Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, Grabowska M, Derkowska I, Juscinska J et al. Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets-results of one year follow-up. Clin Immunol 2014; 153: 23-30.
    • (2014) Clin Immunol , vol.153 , pp. 23-30
    • Marek-Trzonkowska, N.1    Mysliwiec, M.2    Dobyszuk, A.3    Grabowska, M.4    Derkowska, I.5    Juscinska, J.6
  • 10
    • 84874155462 scopus 로고    scopus 로고
    • Boosting regulatory T cell function by CD4 stimulation enters the clinic
    • Becker C, Bopp T, Jonuleit H. Boosting regulatory T cell function by CD4 stimulation enters the clinic. Front immunol 2012; 3: 164.
    • (2012) Front Immunol , vol.3 , pp. 164
    • Becker, C.1    Bopp, T.2    Jonuleit, H.3
  • 11
    • 84899111478 scopus 로고    scopus 로고
    • Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals
    • Mayer CT, Tian L, Hesse C, Kuhl AA, Swallow M, Kruse F et al. Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals. J Autoimmun 2014; 50: 23-32.
    • (2014) J Autoimmun , vol.50 , pp. 23-32
    • Mayer, C.T.1    Tian, L.2    Hesse, C.3    Kuhl, A.A.4    Swallow, M.5    Kruse, F.6
  • 12
    • 84928208326 scopus 로고    scopus 로고
    • A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway
    • Hellling B, König M, Dälken B, Engling A, Krömer W, Heim K et al. A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway. Immunol Cell Biol 2015; 93: 396-405.
    • (2015) Immunol Cell Biol , vol.93 , pp. 396-405
    • Hellling, B.1    König, M.2    Dälken, B.3    Engling, A.4    Krömer, W.5    Heim, K.6
  • 13
    • 84908123494 scopus 로고    scopus 로고
    • Continuous requirement for the TCR in regulatory T cell function
    • Levine AG, Arvey A, Jin W, Rudensky AY. Continuous requirement for the TCR in regulatory T cell function. Nat Immunol 2014; 15: 1070-1078.
    • (2014) Nat Immunol , vol.15 , pp. 1070-1078
    • Levine, A.G.1    Arvey, A.2    Jin, W.3    Rudensky, A.Y.4
  • 14
    • 69849103644 scopus 로고    scopus 로고
    • Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells
    • Becker C, Taube C, Bopp T, Becker C, Michel K, Kubach J et al. Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells. Blood 2009; 114: 1263-1269.
    • (2009) Blood , vol.114 , pp. 1263-1269
    • Becker, C.1    Taube, C.2    Bopp, T.3    Becker, C.4    Michel, K.5    Kubach, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.