The toxicity and distribution of iron oxide-zinc oxide core-shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration

Journal of Applied Toxicology

Volumn 35, Issue 6, 2015, Pages 593-602

  Yun, Jun Won ^a   Yoon, Jung Hee ^a   Kang, Byeong Cheol ^a,b,c   Cho, Nam Hyuk ^b   Seok, Seung Hyeok ^b   Min, Seung Kee ^b   Min, Ji Hyun ^d   Cho, Jeong Hwan ^a,c   Kim, Young Keun ^d  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Seoul National University   (South Korea)

^d Korea University   (South Korea)

Author keywords

Distribution; Excretion; Iron oxide zinc oxide core shell nanoparticles; Nanoparticle; Toxicity

Indexed keywords

CANCER VACCINE; CORE SHELL NANOPARTICLE; IRON OXIDE NANOPARTICLE; NANOPARTICLE; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE; FERRIC ION; FERRIC OXIDE; METAL NANOPARTICLE; ZINC OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CELL INFILTRATION; CONTROLLED STUDY; DENDRITIC CELL; EXCRETION; FEMALE; FLUID INTAKE; FOOD INTAKE; FOREIGN BODY REACTION; GRANULOMATOSIS; HISTOPATHOLOGY; INFLAMMATION; MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; TOXICITY TESTING; URINALYSIS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; PATHOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; MUS;

ANIMALS; FEMALE; FERRIC COMPOUNDS; FOREIGN-BODY REACTION; INJECTIONS, SUBCUTANEOUS; METAL NANOPARTICLES; MICE; MICE, INBRED C57BL; TISSUE DISTRIBUTION; ZINC OXIDE;

EID: 84928208303     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3102     Document Type: Article

References (46)

1. Albanese A, Chan WC. 2011. Effect of gold nanoparticle aggregation on cell uptake and toxicity. ACS Nano 5: 5478-5489.
2. Bae MY, Cho NH, Seong SY. 2009. Protective anti-tumour immune responses by murine dendritic cells pulsed with recombinant Tat-carcinoembryonic antigen derived from Escherichia coli. Clin. Exp. Immunol. 157: 128-138.
3. Banchereau J, Palucka AK. 2005. Dendritic cells as therapeutic vaccines against cancer. Nat. Rev. Immunol. 5: 296-306.
4. Bihari P, Vippola M, Schultes S, Praetner M, Khandoga AG, Reichel CA, Coester C, Tuomi T, Reberg M, Krombach F. 2008. Optimized dispersion of nanoparticles for biological in vitro and in vivo studies. Part. Fibre Toxicol. 5: 14.
5. Cho NH, Cheong TC, Min JH, Wu JH, Lee SJ, Kim D, Yang JS, Kim S, Kim YK, Seong SY. 2011. A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nat. Nanotechnol. 6: 675-682.
6. Cho WS, Cho M, Jeong J, Choi M, Cho HY, Han BS, Kim SH, Kim HO, Lim YT, Chung BH. 2009. Acute toxicity and pharmacokinetics of 13nm-sized PEGcoated gold nanoparticles. Toxicol. Appl. Pharmacol. 236: 16-24.
7. Cho WS, Duffin R, Bradley M, Megson IL, MacNee W, Lee JK, Jeong J, Donaldson K. 2013a. Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles. Part. Fibre Toxicol. 10: 55.
8. Cho WS, Kang BC, Lee JK, Jeong J, Che JH, Seok SH. 2013b. Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. Part. Fibre Toxicol. 10: 9.
9. Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni JV. 2007. Renal clearance of quantum dots. Nat. Biotechnol. 25: 1165-1170.
10. Chun AL. 2009. Will the public swallow nanofood? Nat. Nanotechnol. 4: 790-791.
11. Duffin R, Tran L, Brown D, Stone V, Donaldson K. 2007. Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhal. Toxicol. 19: 849-856.
12. Fang RH, Hu CM, Luk BT, Gao W, Copp JA, Tai Y, O'Connor DE, Zhang L. 2014. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano Lett. 14: 2181-2188.
13. Ferrari M. 2005. Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer 5: 161-171.
14. Fischer HC, Liu L, Pang KS, Chan WCW. 2006. Pharmacokinetics of nanoscale quantum dots: in vivo distribution, sequestration, and clearance in the rat. Adv. Funct. Mater. 16: 1299-1305.
15. Fu C, Liu T, Li L, Liu H, Chen D, Tang F. 2013. The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes. Biomaterials 34: 2565-2575.
16. Fubini B, Ghiazza M, Fenoglio I. 2010. Physico-chemical features of engineered nanoparticles relevant to their toxicity. Nanotoxicology 4: 347-363.
17. Hristozov DR, Gottardo S, Critto A, Marcomini A. 2012. Risk assessment of engineered nanomaterials: a review of available data and approaches from a regulatory perspective. Nanotoxicology 6: 880-898.
18. International Carbon Black Association. 2012. What is Carbon Black. Hebei LongHao Chemical Technology Co., Ltd: Shandong; 1.
19. Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DY. 2010. A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study. Nanotoxicology 4: 42-51.
20. Klippstein R, Pozo D. 2010. Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies. Nanomedicine 6: 523-529.
21. Korea Food and Drug Administration (KFDA). 2005. Good Laboratory Practice Regulation for Non-Clinical Laboratory Studies (Notification no. 2005-79). KFDA: Osong, Korea.
22. Li H, Li Y, Jiao J, Hu HM. 2011. Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response. Nat. Nanotechnol. 6: 645-650.
23. Lipnick RL, Cotruvo JA, Hill RN, Bruce RD, Stitzel KA, Walker AP, Chu I, Goddard M, Segal L, Springer JA, Myers RC. 1995. Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures. Food Chem. Toxicol. 33: 223-231.
24. Liu HL, Wu JH, Min JH, Zhang XY, Kim YK. 2013. Tunable synthesis and multifunctionalities of Fe3O4-ZnO hybrid core-shell nanocrystals. Mater. Res. Bull. 48: 551-558.
25. Lux-Research. 2008. Nanomaterials State of the Market Q3 2008: Stealth Success, Broad Impact. Report. https://portal.luxresearchinc.com/research/document_excerpt/3735/ [1 July 2008].
26. Macleod JN, Sorensen MP, Shapiro BH. 1987. Strain independent elevation of hepatic mono-oxygenase enzymes in female mice. Xenobiotica 17: 1095-1102.
27. Maynard AD, Warheit DB, Philbert MA. 2011. The new toxicology of sophisticated materials: Nanotoxicology and beyond. Toxicol. Sci. 120: S109-S129.
28. Melief CJ. 2008. Cancer immunotherapy by dendritic cells. Immunity 29: 372-383.
29. Meng J, Ji Y, Liu J, Cheng X, Guo H, Zhang W, Wu X, Xu H. 2014. Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice. Nanotoxicology 8: 686-696.
30. Mugford CA, Kedderis GL. 1998. Sex-dependent metabolism of xenobiotics. Drug Metab. Rev. 30: 441-498.
31. Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311: 622-627.
32. NSET. 2010. The National Nanotechnology Initiative. Research and Development Leading to a Revolution in Technology and Industry Supplement to the Present's FY 2011 Budget. Subcommittee on nanoscale Science, Engineering and Technology, Committee on Technology, National Science and Technology Council: Washington; 1-65.
33. Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113: 823-839.
34. OECD. 2001. OECD Guideline for testing of chemicals, Test No.420: Acute Oral Toxicity - Fixed Dose Procedure. OECD: Paris, France.
35. Palucka AK, Ueno H, Fay JW, Banchereau J. 2007. Taming cancer by inducing immunity via dendritic cells. Immunol. Rev. 220: 129-150.
36. Pashine A, Valiante NM, Ulmer JB. 2005. Targeting the innate immune response with improved vaccine adjuvants. Nat. Med. 11: S63-68.
37. Porter D, Sriram K, Wolfarth M, Jefferson A, Schwegler-Berry D, Andrew ME, Castranova V. 2008. A biocompatible medium for nanoparticle dispersion. Nanotoxicology 2: 144-154.
38. Rashidi L, Khosravi-Darani K. 2011. The applications of nanotechnology in food industry. Crit. Rev. Food Sci. Nutr. 51: 723-730.
39. Sager TM, Porter DW, Robinson VA, Lindsley WG, Schwegler-Berry DE, Castranova V. 2007. Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity. Nanotoxicology 1: 118-129.
40. Seong SY, Matzinger P. 2004. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nature Rev. Immunol. 4: 469-478.
41. Sun C, Lee JS, Zhang M. 2008. Magnetic nanoparticles in MR imaging and drug delivery. Adv. Drug Deliv. Rev. 60: 1252-1265.
42. Umbreit TH, Francke-Carroll S, Weaver JL, Miller TJ, Goering PL, Sadrieh N, Stratmeyer ME. 2012. Tissue distribution and histopathological effects of titanium dioxide nanoparticles after intravenous or subcutaneous injection in mice. J. Appl. Toxicol. 32: 350-357.
43. Uto T, Akagi T, Toyama M, Nishi Y, Shima F, Akashi M, Baba M. 2011. Comparative activity of biodegradable nanoparticles with aluminum adjuvants: antigen uptake by dendritic cells and induction of immune response in mice. Immunol. Lett. 140: 36-43. doi:10.1016/j.imlet.2011.06.002.
44. Vasir JK, Reddy MK, Labhasetwar VD. 2005. Nanosystems in drug targeting: opportunities and challenges. Curr. Nanosci. 1: 47-64.
45. Williams GT, Williams WJ. 1983. Granulomatous inflammation-a review. J. Clin. Pathol. 36: 723-733.
46. Wittmaack K. 2007. In search of the relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what? Environ. Health Perspect. 115: 187-194.