Safety and effect on reported symptoms of depigmented polymerized allergen immunotherapy: A retrospective study of 2927 paediatric patients

Pediatric Allergy and Immunology

Volumn 26, Issue 3, 2015, Pages 280-286

  Pfaar, Oliver ^a,b   Sager, Angelika ^c   Robinson, Douglas S ^d,e  

^a Center for Rhinology and Allergology   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c LETI Pharma   (Germany)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^e ROYAL NATIONAL THROAT NOSE AND EAR HOSPITAL   (United Kingdom)

Author keywords

Allergen; Allergen immunotherapy; Allergic rhinoconjunctivitis; Depigmented polymerized; Non interventional study; Real life data

Indexed keywords

ALLERGEN; ANTIHISTAMINIC AGENT; STEROID; HOUSE DUST ALLERGEN; PLANT ANTIGEN;

ADOLESCENT; ALLERGEN IMMUNOTHERAPY; ALLERGIC ASTHMA; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ARTICLE; ATOPIC DERMATITIS; CHILD; COUGHING; DYSPNEA; FEMALE; GRASS POLLEN; HUMAN; IMMUNOTHERAPY; MAINTENANCE DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MITE; OCULAR PRURITUS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RHINOCONJUNCTIVITIS; SNEEZING; SUBCUTANEOUS IMMUNOTHERAPY; SYMPTOM; TREATMENT DURATION; TREATMENT RESPONSE; URTICARIA; ADVERSE EFFECTS; ANIMAL; ASTHMA; CHEMISTRY; COMPLICATION; CONJUNCTIVITIS, ALLERGIC; DESENSITIZATION; EVALUATION STUDY; FOLLOW UP; IMMUNOLOGY; PIGMENTATION; POLLEN; POLYMERIZATION; PRESCHOOL CHILD; PROCEDURES; PYROGLYPHIDAE; RHINITIS, ALLERGIC; SUBCUTANEOUS DRUG ADMINISTRATION;

ADOLESCENT; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ANTIGENS, PLANT; ASTHMA; CHILD; CHILD, PRESCHOOL; CONJUNCTIVITIS, ALLERGIC; DESENSITIZATION, IMMUNOLOGIC; FEMALE; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; PIGMENTATION; POLLEN; POLYMERIZATION; PYROGLYPHIDAE; RETROSPECTIVE STUDIES; RHINITIS, ALLERGIC;

EID: 84928200554     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12347     Document Type: Article

References (23)

1. Bousquet J, Lockey R, Malling HJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol 1998: 102: 558-62.
2. Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008: 63(Suppl 86): 8-160.
3. Noon L, Cantar B. Prophylactic inoculation against hay fever. Lancet 1911: 1: 1572-3.
4. Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S. Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev 2007; (1): CD001936.
5. Dretzke J, Meadows A, Novielli N, Huissoon A, Fry-Smith A, Meads C. Subcutaneous and sublingual immunotherapy for seasonal allergic rhinitis: a systematic review and indirect comparison. J Allergy Clin Immunol 2013: 131: 1361-6.
6. Burks AW, Calderon MA, Casale T, et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol 2013; 131(5): 1288-96.
7. Calderon MA, Gerth van Wijk R, Eichler I, et al. Perspectives on allergen-specific immunotherapy in childhood: an EAACI position statement. Pediatr Allergy Immunol 2012: 23: 300-6.
8. Pfaar O, Bachert C, Bufe A, et al. Guideline on allergen-specific immunotherapy in lgE mediated allergic diseases - S2k Guideline of the German Society for Allergology and Clinical lmmunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and lmmunology (ÖGAl), the Swiss Society for Allergy and lmmunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J lnt 2014: 23: 282-319.
9. Bukantz SC, Bagg AS, Lockey RF. Adverse effects and fatalities associated with subcutaneous allergen immunotherapy. Clin Allergy Immunol 2008: 21: 455-68.
10. Marsh DG. Preparation and properties of, allergoids, derived from native pollen allergens by mild formalin treatment. Int Arch Allergy Appl Immunol 1971: 41: 199-215.
11. Grammer LC, Shaughnessy MA, Patterson R. Modified forms of allergen immunotherapy. J Allergy Clin Immunol 1985: 76: 397-401.
12. Casanovas M, Gomez MJ, Carnes J, Fernandez-Caldas E. Skin tests with native, depigmented and glutaraldehyde polymerized allergen extracts. J Investig Allergol Clin Immunol 2005: 15: 30-6.
13. Fernandez-Caldas E, Gallego M, Carnes J, Iraola V. Enzymatic activity of Dermatophagoides pteronyssinus extracts after acidic treatment. Int Arch Allergy Immunol 2008: 145: 298-304.
14. Brehler R, Klimek L, Pfaar O, Hauswald B, Worm M, Bieber T. Safety of a rush immunotherapy build-up schedule with depigmented polymerized allergen extracts. Allergy Asthma Proc 2010: 31: e31-8.
15. Hoiby AS, Strand V, Robinson DS, Sager A, Rak S. Efficacy, safety, and immunological effects of a 2-year immunotherapy with Depigoid birch pollen extract: a randomized, double-blind, placebo-controlled study. Clin Exp Allergy 2010: 40: 1062-70.
16. Pfaar O, Robinson DS, Sager A, Emuzyte R. Immunotherapy with depigmented-polymerized mixed tree pollen extract: a clinical trial and responder analysis. Allergy 2010: 65: 1614-21.
17. Pfaar O, Urry Z, Robinson DS, et al. A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy*. Allergy 2012: 67: 272-9.
18. Pfaar O, Biedermann T, Klimek L, Sager A, Robinson DS. Depigmented-polymerized mixed grass/birch pollen extract immunotherapy is effective in polysensitized patients. Allergy 2013; 68: 1306-13.
19. Casanovas M, Martin M, Jimenez C, Cabellero R, Fernandez-Caldas E. Safety of immunotherapy with therapeutic vaccines containing depigmented and polymerized allergen extracts. Clin Exp Allergy 2007: 37: 434-40.
20. Pfaar O, Klimek L, Sager A, Brautigam M. Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthma. Am J Rhinol Allergy 2010: 24: 220-5.
21. Crivellaro M, Senna GE, Pappacoda A, et al. Safety of ultrashort-term sit with pollen allergoids adjuvanted by monophosphoryl lipid A: a prospective Italian survey. Eur Ann Allergy Clin Immunol 2011: 43: 58-60.
22. Pfaar O, Demoly P, Gerth van Wijk R, et al. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy 2014: 69: 854-67.
23. Calderon MA, Cox L, Casale TB, Moingeon P, Demoly P. Multiple-allergen and single-allergen immunotherapy strategies in polysensitized patients: looking at the published evidence. J Allergy Clin Immunol 2012: 129: 929-34.