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Volumn 7, Issue 3, 2015, Pages 936-950

Firing the sting: Chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) Venom

Author keywords

Chironex fleckeri; Ethanol induced discharge; Nematocyst; Pressure induced disruption; Proteome; Transcriptome

Indexed keywords

ALCOHOL; ASTACIN; LIQUID NITROGEN; METALLOPROTEINASE; SNAKE VENOM; COELENTERATE VENOM; PROTEOME; SERINE PROTEINASE INHIBITOR; TOXIN-1, CHIRONEX FLECKERI; TRANSCRIPTOME;

EID: 84928169840     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins7030936     Document Type: Article
Times cited : (50)

References (44)
  • 1
    • 84891596416 scopus 로고    scopus 로고
    • Cytotoxic and cytolytic cnidarian venoms. A review on health implications and possible therapeutic applications
    • Mariottini, G.L.; Pane, L. Cytotoxic and cytolytic cnidarian venoms. A review on health implications and possible therapeutic applications. Toxins 2014, 6, 108–151.
    • (2014) Toxins , vol.6 , pp. 108-151
    • Mariottini, G.L.1    Pane, L.2
  • 2
    • 70350397278 scopus 로고    scopus 로고
    • In vivo effects of cnidarian toxins and venoms
    • Suput, D. In vivo effects of cnidarian toxins and venoms. Toxicon 2009, 54, 1190–1200.
    • (2009) Toxicon , vol.54 , pp. 1190-1200
    • Suput, D.1
  • 3
    • 0001370196 scopus 로고
    • The functions of nematocysts in prey capture by epipelagic siphonophores (Coelenterata, Hydrozoa)
    • Purcell, J.E. The functions of nematocysts in prey capture by epipelagic siphonophores (Coelenterata, Hydrozoa). Biol. Bull. 1984, 166, 310–327.
    • (1984) Biol. Bull , vol.166 , pp. 310-327
    • Purcell, J.E.1
  • 4
    • 84864433135 scopus 로고    scopus 로고
    • The nematocyst: A molecular map of the cnidarian stinging organelle
    • Beckmann, A.; Ozbek, S. The nematocyst: a molecular map of the cnidarian stinging organelle. Int. J. Dev. Biol. 2012, 56, 577–582.
    • (2012) Int. J. Dev. Biol , vol.56 , pp. 577-582
    • Beckmann, A.1    Ozbek, S.2
  • 5
    • 0029104293 scopus 로고
    • The cnidarian cnidocyte, a hightech cellular weaponory
    • Tardent, P. The cnidarian cnidocyte, a hightech cellular weaponory. BioEssays 1995, 17, 351–362.
    • (1995) Bioessays , vol.17 , pp. 351-362
    • Tardent, P.1
  • 6
    • 70350369696 scopus 로고    scopus 로고
    • Treatment of Atlantic cnidarian envenomations
    • Burnett, J.W. Treatment of Atlantic cnidarian envenomations. Toxicon 2009, 54, 1201–1205.
    • (2009) Toxicon , vol.54 , pp. 1201-1205
    • Burnett, J.W.1
  • 7
    • 84871214442 scopus 로고    scopus 로고
    • Cubozoan venom-induced cardiovascular collapse is caused by hyperkalemia and prevented by zinc gluconate in mice
    • Yanagihara, A.A.; Shohet, R.V. Cubozoan venom-induced cardiovascular collapse is caused by hyperkalemia and prevented by zinc gluconate in mice. PLoS One 2012, 7, e51368.
    • (2012) Plos One , vol.7
    • Yanagihara, A.A.1    Shohet, R.V.2
  • 8
    • 80052832348 scopus 로고    scopus 로고
    • Immunological and toxinological responses to jellyfish stings. Inflamm
    • Tibballs, J.; Yanagihara, A.A.; Turner, H.C.; Winkel, K. Immunological and toxinological responses to jellyfish stings. Inflamm. Allergy Drug Targets 2011, 10, 438–446.
    • (2011) Allergy Drug Targets , vol.10 , pp. 438-446
    • Tibballs, J.1    Yanagihara, A.A.2    Turner, H.C.3    Winkel, K.4
  • 9
    • 36048959825 scopus 로고    scopus 로고
    • The unusual toxicity and stability properties of crude venom from isolated nematocysts of Pelagia noctiluca (Cnidaria, Scyphozoa)
    • OLOL994–OL1002
    • Marino, A.; Crupi, R.; Rizzo, G.; Morabito, R.; Musci, G.; La Spada, G. The unusual toxicity and stability properties of crude venom from isolated nematocysts of Pelagia noctiluca (Cnidaria, Scyphozoa). Mol. Cell. Biol. 2007, 53, OL994–OL1002.
    • (2007) Mol. Cell. Biol , vol.53
    • Marino, A.1    Crupi, R.2    Rizzo, G.3    Morabito, R.4    Musci, G.5    La Spada, G.6
  • 10
    • 80054901242 scopus 로고    scopus 로고
    • Cnidarians as a source of new marine bioactive compounds-an overview of the last decade and future steps for bioprospecting
    • Rocha, J.; Peixe, L.; Gomes, N.C.; Calado, R. Cnidarians as a source of new marine bioactive compounds-an overview of the last decade and future steps for bioprospecting. Mar. Drugs 2011, 9, 1860–1886.
    • (2011) Mar. Drugs , vol.9 , pp. 1860-1886
    • Rocha, J.1    Peixe, L.2    Gomes, N.C.3    Calado, R.4
  • 11
    • 0038461995 scopus 로고    scopus 로고
    • Drugs from the deep: Marine natural products as drug candidates
    • Haefner, B. Drugs from the deep: marine natural products as drug candidates. Drug Discov. Today 2003, 8, 536–544.
    • (2003) Drug Discov. Today , vol.8 , pp. 536-544
    • Haefner, B.1
  • 13
    • 84891622794 scopus 로고    scopus 로고
    • The role of Cnidaria in drug discovery. A review on CNS implications and new perspectives
    • Mariottini, G.L.; Pane, L. The role of Cnidaria in drug discovery. A review on CNS implications and new perspectives. Recent Pat. CNS Drug Discov. 2013, 8, 110–122.
    • (2013) Recent Pat. CNS Drug Discov , vol.8 , pp. 110-122
    • Mariottini, G.L.1    Pane, L.2
  • 15
    • 84862150164 scopus 로고    scopus 로고
    • Application of nanoLC-MS/MS to the shotgun proteomic analysis of the nematocyst proteins from jellyfish Stomolophus meleagris
    • Li, R.; Yu, H.; Xing, R.; Liu, S.; Qing, Y.; Li, K.; Li, B.; Meng, X.; Cui, J.; Li, P. Application of nanoLC-MS/MS to the shotgun proteomic analysis of the nematocyst proteins from jellyfish Stomolophus meleagris. J. Chromatogr. B 2012, 899, 86–95.
    • (2012) J. Chromatogr. B , vol.899 , pp. 86-95
    • Li, R.1    Yu, H.2    Xing, R.3    Liu, S.4    Qing, Y.5    Li, K.6    Li, B.7    Meng, X.8    Cui, J.9    Li, P.10
  • 16
    • 0000875592 scopus 로고
    • Extraction of Cnidarian Venom from Living Tentacle
    • Pergamon Press: Oxford, UK
    • Barnes, J. Extraction of Cnidarian Venom from Living Tentacle; Animal Toxins, Pergamon Press: Oxford, UK, 1967; pp. 115–129.
    • (1967) Animal Toxins , pp. 115-129
    • Barnes, J.1
  • 17
    • 0014639077 scopus 로고
    • Effects of Chironex fleckeri toxin on the isolated perfused guinea pig heart
    • Turner, R.J.; Freeman, S.E. Effects of Chironex fleckeri toxin on the isolated perfused guinea pig heart. Toxicon 1969, 7, 277–286.
    • (1969) Toxicon , vol.7 , pp. 277-286
    • Turner, R.J.1    Freeman, S.E.2
  • 18
    • 0015091025 scopus 로고
    • Comparison of tentacle extracts from Chiropsalmus quadrigatus and Chironex fleckeri
    • Keen, T.E. Comparison of tentacle extracts from Chiropsalmus quadrigatus and Chironex fleckeri. Toxicon 1971, 9, 249–254.
    • (1971) Toxicon , vol.9 , pp. 249-254
    • Keen, T.E.1
  • 19
    • 41149173010 scopus 로고
    • A study of the biological activity of toxic material derived from nematocysts of the cubomedusan Chironex fleckeri
    • Endean, R.; Duchemin, C.; McColm, D.; Fraser, E.H. A study of the biological activity of toxic material derived from nematocysts of the cubomedusan Chironex fleckeri. Toxicon 1969, 6, 179–204.
    • (1969) Toxicon , vol.6 , pp. 179-204
    • Endean, R.1    Duchemin, C.2    McColm, D.3    Fraser, E.H.4
  • 20
    • 3042711113 scopus 로고    scopus 로고
    • A rapid and repeatable method for venom extraction from cubozoan nematocysts
    • Carrette, T.; Seymour, J. A rapid and repeatable method for venom extraction from cubozoan nematocysts. Toxicon 2004, 44, 135–139.
    • (2004) Toxicon , vol.44 , pp. 135-139
    • Carrette, T.1    Seymour, J.2
  • 21
    • 0031841695 scopus 로고    scopus 로고
    • Partial purification of box jellyfish (Chironex fleckeri) nematocyst venom isolated at the beachside
    • Bloom, D.A.; Burnett, J.W.; Alderslade, P. Partial purification of box jellyfish (Chironex fleckeri) nematocyst venom isolated at the beachside. Toxicon 1998, 36, 1075–1085.
    • (1998) Toxicon , vol.36 , pp. 1075-1085
    • Bloom, D.A.1    Burnett, J.W.2    Alderslade, P.3
  • 22
    • 0018876428 scopus 로고
    • Disarming the box-jellyfish: Nematocyst inhibition in Chironex fleckeri
    • Hartwick, R.; Callanan, V.; Williamson, J. Disarming the box-jellyfish: Nematocyst inhibition in Chironex fleckeri. Med. J. Aust. 1980, 1, 15–20.
    • (1980) Med. J. Aust , vol.1 , pp. 15-20
    • Hartwick, R.1    Callanan, V.2    Williamson, J.3
  • 23
    • 77949289944 scopus 로고    scopus 로고
    • Evaluation of the effects of various chemicals on discharge of and pain caused by jellyfish nematocysts
    • Birsa, L.M.; Verity, P.G.; Lee, R.F. Evaluation of the effects of various chemicals on discharge of and pain caused by jellyfish nematocysts. Comp. Biochem. Physiol. C 2010, 151, 426–430.
    • (2010) Comp. Biochem. Physiol. C , vol.151 , pp. 426-430
    • Birsa, L.M.1    Verity, P.G.2    Lee, R.F.3
  • 24
    • 0027279372 scopus 로고
    • First aid treatment of the sting from the hydroid Lytocarpus philippinus: The structure of, and in vitro discharge experiments with its nematocysts
    • Rifkin, J.F.; Fenner, P.J.; Williamson, J.A. First aid treatment of the sting from the hydroid Lytocarpus philippinus: The structure of, and in vitro discharge experiments with its nematocysts. J. Wilderness Med. 1993, 4, 252–260.
    • (1993) J. Wilderness Med , vol.4 , pp. 252-260
    • Rifkin, J.F.1    Fenner, P.J.2    Williamson, J.A.3
  • 25
    • 84857522821 scopus 로고    scopus 로고
    • Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones
    • Moran, Y.; Genikhovich, G.; Gordon, D.; Wienkoop, S.; Zenkert, C.; Ozbek, S.; Technau, U.; Gurevitz, M. Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones. Proc. Biol. Sci. 2012, 279, 1351–1358.
    • (2012) Proc. Biol. Sci , vol.279 , pp. 1351-1358
    • Moran, Y.1    Genikhovich, G.2    Gordon, D.3    Wienkoop, S.4    Zenkert, C.5    Ozbek, S.6    Technau, U.7    Gurevitz, M.8
  • 27
    • 33745628075 scopus 로고    scopus 로고
    • Nematocysts of the Cubozoa
    • Gershwin, L. Nematocysts of the Cubozoa. Zootaxa 2006, 1232, 1–57.
    • (2006) Zootaxa , vol.1232 , pp. 1-57
    • Gershwin, L.1
  • 28
    • 0036842210 scopus 로고    scopus 로고
    • Nematocyst ratio and prey in two Australian cubomedusans, Chironex fleckeri and Chiropsalmus sp
    • Carrette, T.; Alderslade, P.; Seymour, J. Nematocyst ratio and prey in two Australian cubomedusans, Chironex fleckeri and Chiropsalmus sp. Toxicon 2002, 40, 1547–1551.
    • (2002) Toxicon , vol.40 , pp. 1547-1551
    • Carrette, T.1    Alderslade, P.2    Seymour, J.3
  • 29
    • 84896975872 scopus 로고    scopus 로고
    • Nematocyst discharge in Pelagia noctiluca (Cnidaria, Scyphozoa) oral arms can be affected by lidocaine, ethanol, ammonia and acetic acid
    • Morabito, R.; Marino, A.; Dossena, S.; La Spada, G. Nematocyst discharge in Pelagia noctiluca (Cnidaria, Scyphozoa) oral arms can be affected by lidocaine, ethanol, ammonia and acetic acid. Toxicon 2014, 83, 52–58.
    • (2014) Toxicon , vol.83 , pp. 52-58
    • Morabito, R.1    Marino, A.2    Dossena, S.3    La Spada, G.4
  • 30
    • 84894458340 scopus 로고    scopus 로고
    • Chironex fleckeri (Box Jellyfish) Venom Proteins: Expansion of a cnidarian toxin family that elicits variable cytolytic and cardiovascular effects
    • Brinkman, D.L.; Konstantakopoulos, N.; McInerney, B.V.; Mulvenna, J.; Seymour, J.E.; Isbister, G.K.; Hodgson, W.C. Chironex fleckeri (Box Jellyfish) Venom Proteins: Expansion of a cnidarian toxin family that elicits variable cytolytic and cardiovascular effects. J. Biol. Chem. 2014, 289, 4798–4812.
    • (2014) J. Biol. Chem , vol.289 , pp. 4798-4812
    • Brinkman, D.L.1    Konstantakopoulos, N.2    McInerney, B.V.3    Mulvenna, J.4    Seymour, J.E.5    Isbister, G.K.6    Hodgson, W.C.7
  • 32
    • 34548165755 scopus 로고    scopus 로고
    • Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (Brown spider) venom
    • Da Silveira, R.; Wille, A.; Chaim, O.; Appel, M.; Silva, D.; Franco, C.; Toma, L.; Mangili, O.; Gremski, W.; Dietrich, C. Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom. Biochem. J 2007, 406, 355–363.
    • (2007) Biochem. J , vol.406 , pp. 355-363
    • Da Silveira, R.1    Wille, A.2    Chaim, O.3    Appel, M.4    Silva, D.5    Franco, C.6    Toma, L.7    Mangili, O.8    Gremski, W.9    Dietrich, C.10
  • 33
    • 84904989275 scopus 로고    scopus 로고
    • Clawing through evolution: Toxin diversification and convergence in the ancient lineage Chilopoda (Centipedes)
    • Undheim, E.A.; Jones, A.; Clauser, K.R.; Holland, J.W.; Pineda, S.S.; King, G.F.; Fry, B.G. Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (Centipedes). J. Mol. Biol. 2014, doi:10.1093/molbev/msu162.
    • (2014) J. Mol. Biol
    • Undheim, E.A.1    Jones, A.2    Clauser, K.R.3    Holland, J.W.4    Pineda, S.S.5    King, G.F.6    Fry, B.G.7
  • 34
    • 84899784806 scopus 로고    scopus 로고
    • Jellyfish venomics and venom gland transcriptomics analysis of Stomolophus meleagris to reveal the toxins associated with sting
    • Li, R.; Yu, H.; Xue, W.; Yue, Y.; Liu, S.; Xing, R.; Li, P. Jellyfish venomics and venom gland transcriptomics analysis of Stomolophus meleagris to reveal the toxins associated with sting. J. Proteomics 2014, 106, 17–29.
    • (2014) J. Proteomics , vol.106 , pp. 17-29
    • Li, R.1    Yu, H.2    Xue, W.3    Yue, Y.4    Liu, S.5    Xing, R.6    Li, P.7
  • 35
    • 84876164436 scopus 로고    scopus 로고
    • Analysis of soluble protein contents from the nematocysts of a model sea anemone sheds light on venom evolution
    • Moran, Y.; Praher, D.; Schlesinger, A.; Ayalon, A.; Tal, Y.; Technau, U. Analysis of soluble protein contents from the nematocysts of a model sea anemone sheds light on venom evolution. Mar. Biotechnol. 2013, 15, 329–339.
    • (2013) Mar. Biotechnol , vol.15 , pp. 329-339
    • Moran, Y.1    Praher, D.2    Schlesinger, A.3    Ayalon, A.4    Tal, Y.5    Technau, U.6
  • 37
    • 84907126507 scopus 로고
    • Modified elastic tissue-Masson trichrome stain
    • Garvey, W. Modified elastic tissue-Masson trichrome stain. Stain Technol. 1984, 59, 213–216.
    • (1984) Stain Technol , vol.59 , pp. 213-216
    • Garvey, W.1
  • 40
    • 24644503098 scopus 로고    scopus 로고
    • Blast2GO: A universal tool for annotation, visualization and analysis in functional genomics research
    • Conesa, A.; Gotz, S.; Garcia-Gomez, J.M.; Terol, J.; Talon, M.; Robles, M. Blast2GO: A universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 2005, 21, 3674–3676.
    • (2005) Bioinformatics , vol.21 , pp. 3674-3676
    • Conesa, A.1    Gotz, S.2    Garcia-Gomez, J.M.3    Terol, J.4    Talon, M.5    Robles, M.6
  • 41
    • 34248531753 scopus 로고    scopus 로고
    • Locating proteins in the cell using TargetP, SignalP and related tools
    • Emanuelsson, O.; Brunak, S.; von Heijne, G.; Nielsen, H. Locating proteins in the cell using TargetP, SignalP and related tools. Nat. Protoc. 2007, 2, 953–971.
    • (2007) Nat. Protoc , vol.2 , pp. 953-971
    • Emanuelsson, O.1    Brunak, S.2    Von Heijne, G.3    Nielsen, H.4
  • 42
    • 0034800374 scopus 로고    scopus 로고
    • InterProScan–an integration platform for the signature-recognition methods in InterPro
    • Zdobnov, E.M.; Apweiler, R. InterProScan–an integration platform for the signature-recognition methods in InterPro. Bioinformatics 2001, 17, 847–848.
    • (2001) Bioinformatics , vol.17 , pp. 847-848
    • Zdobnov, E.M.1    Apweiler, R.2
  • 43
    • 84879581519 scopus 로고    scopus 로고
    • The molybdoproteome of Starkeya novella–insights into the diversity and functions of molybdenum containing proteins in response to changing growth conditions
    • Kappler, U.; Nouwens, A.S. The molybdoproteome of Starkeya novella–insights into the diversity and functions of molybdenum containing proteins in response to changing growth conditions. Metallomics 2013, 5, 325–334.
    • (2013) Metallomics , vol.5 , pp. 325-334
    • Kappler, U.1    Nouwens, A.S.2


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