Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation

Experimental Neurology

Volumn 269, Issue , 2015, Pages 120-132

  Ladas, Thomas P ^a   Chiang, Chia Chu ^a   Gonzalez Reyes, Luis E ^a   Nowak, Theodore ^a   Durand, Dominique M ^a  

^a Case Western Reserve University   (United States)

Author keywords

GABA interneuron; Low frequency stimulation; Mesial temporal lobe epilepsy; Optogenetics; Seizure suppression

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CATION CHANNEL; CHANNELRHODOPSIN 2; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL DENSITY; CELL FUNCTION; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ELECTROSTIMULATION; EPILEPTIC FOCUS; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; IN VIVO STUDY; INTERNEURON; LOW FREQUENCY OPTICAL STIMULATION; MALE; MOUSE; NERVE CELL INHIBITION; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE EXCITABILITY; NERVE POTENTIAL; NONHUMAN; OPTOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SEIZURE; ANIMAL; C57BL MOUSE; HIPPOCAMPUS; MEMBRANE POTENTIAL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SEIZURES; TEMPORAL LOBE EPILEPSY; TRANSGENIC MOUSE;

ANIMALS; ELECTRIC STIMULATION; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; INTERNEURONS; MEMBRANE POTENTIALS; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURAL INHIBITION; RECEPTORS, GABA-A; SEIZURES;

EID: 84928157110     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2015.04.001     Document Type: Article

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