The epitope recognized by monoclonal antibody 2B6 in the B/C domains of classical swine fever virus glycoprotein E2 affects viral binding to hyperimmune sera and replication

Journal of Microbiology and Biotechnology

Volumn 25, Issue 4, 2015, Pages 537-546

  Tong, Chao ^a   Chen, Ning ^a   Liao, Xun ^a   Xie, Wenqi ^a   Li, Dejiang ^a   Li, Xiaoliang ^a   Fang, Weihuan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Classical swine fever virus; E2 glycoprotein; Epitope mapping

Indexed keywords

EPITOPE; GLYCOPROTEIN E2; HYPERIMMUNE GLOBULIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2B6; PROLINE; UNCLASSIFIED DRUG; GLYCOPROTEIN E2, CLASSICAL SWINE FEVER VIRUS; NEUTRALIZING ANTIBODY; PROTEIN BINDING; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; BINDING SITE; CLASSICAL SWINE FEVER VIRUS; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; IN VITRO STUDY; NEW ZEALAND WHITE (RABBIT); NONHUMAN; PROTEIN DOMAIN; SWINE; VIRUS ATTACHMENT; VIRUS MUTANT; VIRUS NEUTRALIZATION; VIRUS PARTICLE; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; CELL LINE; CHEMISTRY; EPITOPE MAPPING; GENETICS; GENOTYPE; IMMUNOLOGY; METABOLISM; MUTATION; PHYSIOLOGY; PIG; SERODIAGNOSIS;

CLASSICAL SWINE FEVER VIRUS; SUIDAE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CELL LINE; CLASSICAL SWINE FEVER VIRUS; EPITOPE MAPPING; EPITOPES; GENOTYPE; MUTATION; NEUTRALIZATION TESTS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; SWINE; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

EID: 84928107238     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.1407.07073     Document Type: Article

References (39)

1. Becher P, Avalos Ramirez R, Orlich M, Cedillo Rosales S, Konig M, Schweizer M, et al. 2003. G enetic a nd a ntigenic characterization of novel pestivirus genotypes: implications for classification. Virology 311: 96-104.
2. Chang CY, Huang CC, Lin YJ, Deng MC, Chen HC, Tsai CH, et al. 2010. Antigenic domains analysis of classical swine fever virus E2 glycoprotein by mutagenesis and conformation-dependent monoclonal antibodies. Virus Res. 149: 183-189.
3. Chang CY, Huang CC, Lin YJ, Deng MC, Tsai CH, Chang WM, Wang FI. 2010. Identification of antigen-specific residues on E2 glycoprotein of classical swine fever virus. Virus Res. 152: 65-72.
4. Chen N, Hu H, Zhang Z, Shuai J, Jiang L, Fang W. 2008. Genetic diversity of the envelope glycoprotein E2 of classical swine fever virus: recent isolates branched away from historical and vaccine strains. Vet. Microbiol. 127: 286-299.
5. Chen N, Li D, Yuan X, Li X, Hu H, Zhu B, et al. 2010. Genetic characterization of E2 gene of classical swine fever virus by restriction fragment length polymorphism and phylogenetic analysis. Virus Genes 40: 389-396.
6. Chen N, Tong C, Li D, Wan J, Yuan X, Li X, et al. 2010. Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China. Virol. J. 7: 378.
7. Colijn EO, Bloemraad M, Wensvoort G. 1997. An improved ELISA for the detection of serum antibodies directed against classical swine fever virus. Vet. Microbiol. 59: 15-25.
8. Deng MC, Huang CC, Huang TS, Chang CY, Lin YJ, Chien MS, Jong MH. 2005. Phylogenetic analysis of classical swine fever virus isolated from Taiwan. Vet. Microbiol. 106: 187-193.
9. Kortekaas J, Ketelaar J, Vloet RP, Loeffen WL. 2011. Protective efficacy of a classical swine fever virus C-strain deletion mutant and ability to differentiate infected from vaccinated animals. Vet. Microbiol. 147: 11-18.
10. Kortekaas J, Vloet RP, Weerdmeester K, Ketelaar J, van Eijk M, Loeffen WL. 2010. Rational design of a classical swine fever C-strain vaccine virus that enables the differentiation between infected and vaccinated animals. J. Virol. Methods 163: 175-185.
11. Kosmidou A, Ahl R, Thiel HJ, Weiland E. 1995. Differentiation of classical swine fever virus (CSFV) strains using monoclonal antibodies against structural glycoproteins. Vet. Microbiol. 47: 111-118.
12. Li M, Wang YF, Wang Y, Gao H, Li N, Sun Y, et al. 2009. Immune responses induced by a BacMam virus expressing the E2 protein of classical swine fever virus in mice. Immunol. Lett. 125: 145-150.
13. Lin M, Lin F, Mallory M, Clavijo A. 2000. Deletions of structural glycoprotein E2 of classical swine fever virus strain alfort/187 resolve a linear epitope of monoclonal antibody WH303 and the minimal N-terminal domain essential for binding immunoglobulin G antibodies of a pig hyperimmune serum. J. Virol. 74: 11619-11625.
14. Lindenbach BD, Rice CM. 2003. Molecular biology of flaviviruses. Adv. Virus Res. 59: 23-61.
15. Liu L, Xia H, Wahlberg N, Belak S, Baule C. 2009. Phylogeny, classification and evolutionary insights into pestiviruses. Virology 385: 351-357.
16. Liu S, Tu C, Wang C, Yu X, Wu J, Guo S, et al. 2006. The protective immune response induced by B cell epitope of classical swine fever virus glycoprotein E2. J. Virol. Methods 134: 125-129.
17. Luo TR, Liao SH, Wu XS, Feng L, Yuan ZX, Li H, et al. 2011. Phylogenetic analysis of the E2 gene of classical swine fever virus from the Guangxi Province of southern China. Virus Genes 42: 347-354.
18. Mendoza S, Correa-Giron P, Aguilera E, Colmenares G, Torres O, Cruz T, et al. 2007. Antigenic differentiation of classical swine fever vaccinal strain PAV-250 from other strains, including field strains from Mexico. Vaccine 25: 7120-7124.
19. Moennig V. 2000. Introduction to classical swine fever: virus, disease and control policy. Vet. Microbiol. 73: 93-102.
20. Nishimori T, Yamada S, Shimizu M. 1996. Production of monoclonal antibodies against classical swine fever virus and their use for antigenic characterization of Japanese isolates. J. Vet. Med. Sci. 58: 707-710.
21. Paton DJ. 1995. Pestivirus diversity. J. Comp. Pathol. 112: 215-236.
22. Paton DJ, McGoldrick A, Bensaude E, Belak S, Mittelholzer C, Koenen F, et al. 2000. Classical swine fever virus: a second ring test to evaluate RT-PCR detection methods. Vet. Microbiol. 77: 71-81.
23. Paton DJ, McGoldrick A, Greiser-Wilke I, Parchariyanon S, Song JY, Liou PP, et al. 2000. Genetic typing of classical swine fever virus. Vet. Microbiol. 73: 137-157.
24. Peng WP, Hou Q, Xia ZH, Chen D, Li N, Sun Y, Qiu HJ. 2008. Identification of a conserved linear B-cell epitope at the N-terminus of the E2 glycoprotein of classical swine fever virus by phage-displayed random peptide library. Virus Res. 135: 267-272.
25. Postel A, Schmeiser S, Bernau J, Meindl-Boehmer A, Pridotkas G, Dirbakova Z, et al. 2012. Improved strategy for phylogenetic analysis of classical swine fever virus based on full-length E2 encoding sequences. Vet. Res. 43: 50.
26. Postel A, Schmeiser S, Perera CL, Rodriguez LJ, Frias-Lepoureau MT, Becher P. 2013. Classical swine fever virus isolates from Cuba form a new subgenotype 1. 4. Vet. Microbiol. 161: 334-338.
27. Qi Y, Zhang BQ, Shen Z, Chen YH. 2009. Candidate vaccine focused on a classical swine fever virus epitope induced antibodies with neutralizing activity. Viral Immunol. 22: 205-213.
28. Reimann I, Depner K, Utke K, Leifer I, Lange E, Beer M. 2010. Characterization of a new chimeric marker vaccine candidate with a mutated antigenic E2-epitope. Vet. Microbiol. 142: 45-50.
29. Rumenapf T, Unger G, Strauss JH, Thiel HJ. 1993. Processing of the envelope glycoproteins of pestiviruses. J. Virol. 67: 3288-3294.
30. Sainz IF, Holinka LG, Lu Z, Risatti GR, Borca MV. 2008. Removal of a N-linked glycosylation site of classical swine fever virus strain Brescia Erns glycoprotein affects virulence in swine. Virology 370: 122-129.
31. Sun SQ, Y in SH, G uo H C, Jin Y, Shang YJ, L iu XT. 2013. Genetic typing of classical swine fever virus isolates from China. Transbound. Emerg. Dis. 60: 370-375.
32. Sun Y, Liu DF, Wang YF, Liang BB, Cheng D, Li N, et al. 2010. Generation and efficacy evaluation of a recombinant adenovirus expressing the E2 protein of classical swine fever virus. Res. Vet. Sci. 88: 77-82.
33. Tu C, Lu Z, Li H, Yu X, Liu X, Li Y, et al. 2001. Phylogenetic comparison of classical swine fever virus in China. Virus Res. 81: 29-37.
34. van Rijn PA. 2007. A common neutralizing epitope on envelope glycoprotein E2 of different pestiviruses: implications for improvement of vaccines and diagnostics for classical swine fever (CSF)? Vet. Microbiol. 125: 150-156.
35. van Rijn PA, van Gennip HG, de Meijer EJ, Moormann RJ. 1993. Epitope mapping of envelope glycoprotein E1 of hog cholera virus strain Brescia. J. Gen. Virol. 74: 2053-2060.
36. van Rijn PA, Miedema GK, Wensvoort G, van Gennip HG, Moormann RJ. 1994. Antigenic structure of envelope glycoprotein E1 of hog cholera virus. J. Virol. 68: 3934-3942.
37. Wang Z, Nie Y, Wang P, Ding M, Deng H. 2004. Characterization of classical swine fever virus entry by using pseudotyped viruses: E1 and E2 are sufficient to mediate viral entry. Virology 330: 332-341.
38. Zhang F, Yu M, Weiland E, Morrissy C, Zhang N, Westbury H, Wang LF. 2006. Characterization of epitopes for neutralizing monoclonal antibodies to classical swine fever virus E2 and Erns using phage-displayed random peptide library. Arch. Virol. 151: 37-54.
39. Zhu Y, Shi Z, Drew TW, Wang Q, Qiu H, Guo H, Tu C. 2009. Antigenic differentiation of classical swine fever viruses in China by monoclonal antibodies. Virus Res. 142: 169-174.