Relationship of serum estrogens and estrogen metabolites to postmenopausal breast cancer risk: A nested case-control study

Breast Cancer Research

Volumn 15, Issue 2, 2013, Pages

  Falk, Roni T ^a   Brinton, Louise A ^a   Dorgan, Joanne F ^b   Fuhrman, Barbara J ^c   Veenstra, Timothy D ^d   Xu, Xia ^d   Gierach, Gretchen L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16 OXOESTRADIOL; 16ALPHA HYDROXYESTRONE; 17 EPIESTRIOL; 2 HYDROXYESTRADIOL; 2 HYDROXYESTRONE; 2 METHOXYESTRADIOL; 2 METHOXYESTRONE; 4 HYDROXYESTRONE; 4 METHOXYESTRADIOL; 4 METHOXYESTRONE; CATECHOL; CONJUGATED ESTROGEN; EPIESTRIOL; ESTRADIOL; ESTRIOL; ESTROGEN; ESTROGEN DERIVATIVE; ESTRONE; UNCLASSIFIED DRUG; UNCONJUGATED ESTROGEN; DIMETHYL ETHER; EPIMESTROL;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; CONTROLLED STUDY; ESTROGEN BLOOD LEVEL; ESTROGEN METABOLISM; FEMALE; HUMAN; HYDROXYLATION; MAJOR CLINICAL STUDY; MIDDLE AGED; POSTMENOPAUSE; CANCER INCIDENCE; ESTRADIOL BLOOD LEVEL; ESTRONE BLOOD LEVEL; LIQUID CHROMATOGRAPHY; RADIOIMMUNOASSAY; TANDEM MASS SPECTROMETRY;

EID: 84928104680     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3416     Document Type: Article

References (21)

1. Key TJ, Appleby P, Barnes I, Reeves G. Endogenous Hormones and Breast Cancer Collaborative Group Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002, 94:606-616. 10.1093/jnci/94.8.606, 11959894, Endogenous Hormones and Breast Cancer Collaborative Group.
2. Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Engl J Med 2006, 354:270-282. 10.1056/NEJMra050776, 16421368.
3. Chang M. Dual roles of estrogen metabolism in mammary carcinogenesis. BMB Rep 2011, 44:423-434. 10.5483/BMBRep.2011.44.7.423, 21777512.
4. Bolton JL, Thatcher GRJ. Potential mechanisms of estrogen quinine carcinogenesis. Chem Res Toxicol 2008, 21:93-101. 10.1021/tx700191p, 2556295, 18052105.
5. Cavalieri E, Chakravarti D, Guttenplan J, Hart E, Ingle J, Jankowiak R, Muti P, Rogan E, Russo J, Santen R, Sutter T. Catechol estrogen quinines as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention. Biochem Biophys Acta 2006, 1766:63-78.
6. Cavalieri E, Frenkel K, Liehr JG, Rogan E, Roy D. Estrogens as endogenous genotoxic agents-DNA adducts and mutations. J Natl Cancer Inst Monogr 2000, 27:75-93.
7. Xu X, Roman JM, Issaq HJ, Keefer LK, Veenstra TD, Ziegler RG. Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry. Anal Chem 2007, 79:7813-7821. 10.1021/ac070494j, 17848096.
8. Fuhrman BJ, Schairer C, Gail MH, Boyd-Martin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG. Estrogen metabolism and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2012, 104:326-329. 10.1093/jnci/djr531, 3283536, 22232133.
9. Dorgan JF, Longcope C, Stephenson HE, Falk RT, Miller R, Franz C, Kayle L, Campbell WS, Tangrea JA, Schatzkin A. Relation of prediagnostic serum estrogen and androgen levels to breast cancer risk. Cancer Epidemiol Biomarkers Prev 1996, 5:533-539.
10. Wilkinson L. SYSTAT: The System for Statistics, version 12. 2010, Evanston IL: SYSTAT, Inc.
11. StataCorp: Stata Software: Release 11 2009, College Station, TX: StataCorp LP.12, StataCorp: Stata Software: Release 11.
12. Endogenous Hormones and Breast Cancer Collaborative Group: Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies Br J Cancer 2011, 105:709-722. 10.1038/bjc.2011.254, 3188939, 21772329, Endogenous Hormones and Breast Cancer Collaborative Group: Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies.
13. Kratz A, Ferraro M, Sluss PM, Lewandrowski KB. Laboratory reference values. N Engl J Med 2004, 351:1548-1563. 10.1056/NEJMcpc049016, 15470219.
14. Stanway SJ, Purohit A, Reed MJ. Measurement of estrone sulfate in postmenopausal women: comparison of direct RIA and GC-MS/MS methods for monitoring response to endocrine therapy in women with breast cancer. Anticancer Res 2007, 27:2765-2767.
15. Toniolo P, Koenig KL, Pasternack BS, Banerjee S, Rosenberg C, Shore RE, Strax P, Levitz M. Reliability of measurements of total, protein-bound and unbound estradiol in serum. Cancer Epidemiol Biomarkers Prev 1994, 3:47-50.
16. Cauley JA, Gutai JP, Kuller LH, Powell JG. Reliability and interrelations among serum sex hormones in postmenopausal women. Am J Epidemiol 1991, 133:50-57.
17. Falk RT, Dorgan JF, Kahle L, Potischman N, Longcope C. Assay reproducibility of hormone measurements in postmenopausal women. Cancer Epidemiol Biomarkers Prev 1997, 6:429-432.
18. Hankinson SE, Eliassen AH. Endogenous estrogen, testosterone, and progesterone levels in relation to breast cancer risk. J Steroid Biochem Mol Biol 2007, 106:24-30. 10.1016/j.jsbmb.2007.05.012, 2715949, 17719770.
19. Hankinson SE, Manson JE, Spiegelman D, Willet QC, Longcope C, Speizer FE. Reproducibility of plasma hormone levels in postmenopausal women over a 2-3 year period. Cancer Epidemiol Biomarkers Prev 1995, 4:649-654.
20. Liehr JG. Is estradiol a genotoxic mutagenic carcinogen?. Endocr Rev 2000, 21:40-54.
21. Folkerd EJ, Martin L, Kendall A, Dowsett M. The relationship between factors affecting endogenous oestradiol levels in postmenopausal women and breast cancer. J Steroid Biochem Mol Biol 2006, 102:250-255. 10.1016/j.jsbmb.2006.09.024, 17049846.