The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Lu, Kai ^a   Basu, Sujit ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPYRAN DERIVATIVE; BIOLOGICAL PRODUCT; CHEBULAGIC ACID; GLUCOSIDE; PLANT EXTRACT; TRIPHALA; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; CHICKEN; DRUG EFFECTS; ENDOTHELIUM CELL; HUMAN; METABOLISM; MOUSE; PERMEABILITY; PHOSPHORYLATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; BENZOPYRANS; BIOLOGICAL PRODUCTS; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CHICKENS; ENDOTHELIAL CELLS; GLUCOSIDES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PERMEABILITY; PHOSPHORYLATION; PLANT EXTRACTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84928034368     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09642     Document Type: Article

References (21)

1. Dvorak, H. F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. 20, 4368-4380 (2002).
2. Ferrara, N. Vascular endothelial growth factor. Arterioscler. Thromb. Vasc. Biol. 29, 789-791 (2009).
3. Sloan, B. & Scheinfeld, N. S. Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy. Curr. Opin. Investig. Drugs. 9, 1324-1335 (2008).
4. Sullivan, L. A. & Brekken, R. A. The VEGF family in cancer and antibody-based strategies for their inhibition. MAbs. 2, 165-175 (2010).
5. Niraula, S., Amir, E., Vera-Badillo, F., Seruga, B., Ocana, A. & Tannock, I. F. Risk of incremental toxicities and associated costs of new anticancer drugs: a metaanalysis. J. Clin. Oncol. 32, 3634-3642 (2014).
6. Baliga,M. S. Triphala, Ayurvedic formulation for treating and preventing cancer: a review. J. Altern. Complement. Med. 16, 1301-1308 (2010).
7. Lu, K. et al. Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-A mediated angiogenesis. PLoS One 7, e43934 (2012).
8. Singh, D. P., Govindarajan, R. & Rawat, A. K. High-performance liquid chromatography as a tool for the chemical standardisation of Triphala- an Ayurvedic formulation. Phytochem. Anal. 19, 164-168 (2008).
9. Pawar, V., Lahorkar, P. & Anantha Narayana, D. B. Development of a RP-HPLC method for analysis of Triphala Curna and its applicability to test variations in Triphala Curna preparations. Indian J. Pharm. Sci. 71, 382-386 (2009).
10. Ferruzzi, M. G. et al. Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. J. Alzheimers. Dis. 18, 113-124 (2009).
11. Seeram, N. P., Lee, R. & Heber, D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin. Chim. Acta. 348, 63-68 (2004).
12. Hussain, S. et al . Anti-angiogenic activity of sesterterpenes; natural product inhibitors of FGF-2-induced angiogenesis. Angiogenesis 11, 245-256 (2008).
13. Ribatti, D., Nico, B., Vacca, A. & Presta, M. The gelatin sponge-chorioallantoic membrane assay. Nat. Protoc. 1, 85-91 (2006).
14. Hoeben, A. et al. Vascular endothelial growth factor and angiogenesis. Pharmacol. Rev. 56, 549-580 (2004).
15. Li, L., Wilbur, C. L. & Mintz, K. L. Kinetics of hydrothermal inactivation of endotoxins. Appl. Environ. Microbiol. 77, 2640-2647 (2011).
16. Basu, S. et al The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat. Med. 7, 569-574 (2001).
17. Chakroborty, D. et al. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc. Natl. Acad. Sci. U S A 108, 20730-20735 (2011).
18. Istivan, T. S. et al.Biological effects of a de novo designed myxoma virus peptide analogue: evaluation of cytotoxicity on tumor cells. PLoS One 6, e24809 (2011).
19. Kumar, B. et al. VEGF-C differentially regulates VEGFA expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway. Angiogenesis 14, 371-380 (2011).
20. Sarkar, C., Chakroborty, D., Chowdhury, U. R., Dasgupta, P. S. & Basu, S. Dopamine increases the efficacy of anticancer drugs in breast and colon cancer preclinical models. Clin. Cancer Res. 14, 2502-2510 (2008).
21. Antonescu, C. R. et al (2009) KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors. Cancer Res. 69, 7175-7179 (2009).