Which technique for radiation is most beneficial for patients with locally advanced cervical cancer? Intensity modulated proton therapy versus intensity modulated photon treatment, helical tomotherapy and volumetric arc therapy for primary radiation - an intraindividual comparison

Radiation Oncology

Volumn 10, Issue 1, 2015, Pages

  Marnitz, Simone ^a   Wlodarczyk, Waldemar ^a   Neumann, Oliver ^a   Koehler, Christhardt ^a   Weihrauch, Mirko ^a   Budach, Volker ^a   Cozzi, Luca ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

Cervical cancer; Intensity modulated radiotherapy; Proton therapy; VMAT

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; BLADDER; BRACHYTHERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; INTENSITY MODULATED PROTON THERAPY; INTENSITY MODULATED RADIATION THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTON THERAPY; RADIATION DOSE; RADIOTHERAPY PLANNING SYSTEM; RECTUM; SMALL INTESTINE; TOMOTHERAPY; TOMOTHERAPY SYSTEM; UTERINE CERVIX CANCER; VOLUMETRIC ARC THERAPY; ADENOCARCINOMA; CANCER GRADING; CANCER STAGING; CARCINOMA, SQUAMOUS CELL; FOLLOW UP; MIDDLE AGED; ORGANS AT RISK; PATHOLOGY; PELVIS; PHOTON; PROCEDURES; PROGNOSIS; RADIATION RESPONSE; RADIOTHERAPY DOSAGE; THERAPEUTIC USE; UTERINE CERVICAL NEOPLASMS;

ADENOCARCINOMA; ADULT; AGED; CARCINOMA, SQUAMOUS CELL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; ORGANS AT RISK; PELVIS; PHOTONS; PROGNOSIS; PROTON THERAPY; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; RECTUM; URINARY BLADDER; UTERINE CERVICAL NEOPLASMS;

EID: 84928009485     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/s13014-015-0402-z     Document Type: Article

References (33)

1. Morris M, Eifel PJ, Lu J, Grgsby P, Levenback C, Stevens R, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med. 1999;340:1137-43.
2. Vale C, Tierney JF, Stewart LA, Brady M, Dinshaw K, Jakobsen A, et al. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol. 2008;26:5802-12.
3. Green JA, Kirwan JM, Tierney JF, Symonds L, Collingwood M, Williams C. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet. 2001;358:781-6.
4. Kirwan JM, Symonds P, Green JA, Tierney J, Collingwood M, Williams C. A systematic review of acute and late toxicity of concomitant chemoradiation for cervical cancer. Radiother Oncol. 2003;68:217-26.
5. Varia MA, Bundy BN, Deppe G, Mannel R, Averette H, Rose P, et al. Cervical carcinoma metastatic to para-aortic nodes: extended field radiation therapy with concomitant 5-fluorouracil and cisplatin chemotherapy: a Gynecologic Oncology Group study. Int J Radiat Oncol Biol Phys. 1998;42:1015-23.
6. Grigsby PW, Lu JD, Mutch DG, Kim R, Eifel P. Twice-daily fractionation of external irradiation with brachytherapy and chemotherapy in carcinoma of the cervix with positive para-aortic lymph nodes: Phase II study of the Radiation Therapy Oncology Group 92-10. Int J Radiat Oncol Biol Phys. 1998;41:817-22.
7. Small W, Winter K, Levenback C, Iyer R, Gaffney D, Asbell S, et al. Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of ARM 1 of RTOG 0116. Int J Radiat Oncol Biol Phys. 2007;68:1081-7.
8. Rotman M, Pajak TF, Choi K, Clery M, Marcial V, Grigsby P, et al. Prophylactic extended-field irradiation of para-aortic lymph nodes in stages IIB and bulky IB and IIA cervical carcinomas. Ten-year treatment results of RTOG 79-20. JAMA. 1995;274:387-93.
9. Portelance L, Chao KS, Grigsby PW, Bennet H, Low D. Intensity-modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and para-aortic irradiation. Int J Radiat Oncol Biol Phys. 2001;51:261-6.
10. Mundt AJ, Roeske JC, Lujan AE, Yamada S, Waggoner S, Fleming G, et al. Initial clinical experience with intensity-modulated whole-pelvis radiation therapy in women with gynecologic malignancies. Gynecol Oncol. 2001;82:456-63.
11. Beriwal S, Gan GN, Heron DE, Selvaraj R, Kim H, Lalonde R, et al. Early clinical outcome with concurrent chemotherapy and extended-field, intensity-modulated radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2007;68:166-71.
12. Kavanagh BD, Pan CC, Dawson LA, Das S, Li X, Ten Haken R, et al. Radiation dose-volume effects in the stomach and small bowel. Int J Radiat Oncol Biol Phys. 2010;76:S101-7.
13. Chen MF, Tseng CJ, Tseng CC, Yu C, Wu C, Chen W. Adjuvant concurrent chemoradiotherapy with intensity-modulated pelvic radiotherapy after surgery for high-risk, early stage cervical cancer patients. Cancer J. 2008;14:200-6.
14. Isohashi F, Yoshioka Y, Mabuchi S, Konishi K, Koizumi M, Takahashi Y, et al. Dose volume histogram predictors of chronic gastrointestinal complications after radical hysterectomy and postoperative concurrent nedaplatin based chemoradiation therapy for early stage cervical cancer. Int J Radiat Oncol Biol Phys. 2013;85:728-34.
15. Chopra S, Dora T, Chinnachamy A, Thomas B, Kannan S, Engineer R, et al. Predictors of grade 3 or higher late bowel toxicity in patients undergoing pelvic radiation for cervical cancer: results from a prospective study. Int J Radiat Oncol Biol Phys. 2014;88:630-5.
16. Song WY, Huh SN, Liang Y, White G, Nichols R, Watkins W, et al. Dosimetric comparison study between intensity modulated radiation therapy and three-dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer. J Appl Clin Med Phys. 2010;11:3255.
17. van de Water TA, Lomax AJ, Bijl HP, de Jong M, Schilstra C, Hug E, et al. Potential benefits of scanned intensity-modulated proton therapy versus advanced photon therapy with regard to sparing of the salivary glands in oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2011;79:1216-24.
18. Weber DC, Wang H, Cozzi L, Dipasquale G, Khan H, Ratib O, et al. RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study. Radiat Oncol. 2009;4:34.
19. Zhang X, Li Y, Pan X, Xiaogiang L, Mohan R, Komaki R, et al. Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB non-small-cell lung cancer: a virtual clinical study. Int J Radiat Oncol Biol Phys. 2010;77:357-66.
20. Boehling NS, Grosshans DR, Bluett JB, Palmer M, Song X, Amos R, et al. Dosimetric comparison of three-dimensional conformal proton radiotherapy, intensity-modulated proton therapy, and intensity-modulated radiotherapy for treatment of pediatric craniopharyngiomas. Int J Radiat Oncol Biol Phys. 2010;82:643-52.
21. Georg D, Georg P, Hillbrand M, Poetter R, Mock U. Assessment of improved organ at risk sparing for advanced cervix carcinoma utilizing precision radiotherapy techniques. Strahlenther Onkol. 2008;184:586-91.
22. Milby AB, Both S, Ingram M, Lin L. Dosimetric comparison of combined intensity-modulated radiotherapy (IMRT) and proton therapy versus IMRT alone for pelvic and para-aortic radiotherapy in gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2010;82:e477-84.
23. Kagei K, Tokuuye K, Okumura T, Ohara K, Shioyama Y, Sugahara S, et al. Long-term results of proton beam therapy for carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys. 2003;55:1265-71.
24. Small W, Mell L, Anderson P, Creutzberg C, De Los Santos J, Gaffney D, et al. Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer. Int J Radiat Oncol Biol Phys. 2008;71:428-34.
25. Japan Clinical Oncology Group, Toita T, Ohno T, Kaneyasu Y, Uno T, Yoshimura R, et al. A consensus-based guideline defining the clinical target volume for pelvic lymph nodes in external beam radiotherapy for uterine cervical cancer. Jpn J Clin Oncol. 2010;40:456-63.
26. Gillin MT, Sahoo N, Bues M, Ciangaru G, Poenisch F, Arjomandy B, et al. Commissioning of the discrete spot scanning proton beam delivery system at the University of Texas M.D. Anderson Cancer Center, Proton Therapy Center, Houston. Med Phys. 2010;37:154-63.
27. Arjomandy B, Sahoo N, Ciangaru G, Zhu R, Song X, Gillin M. Verification of patient-specific dose distributions in proton therapy using a commercial two-dimensional ion chamber array. Med Phys. 2010;37:5831-7.
28. Feuvret L, Noel G, Mazeron JJ, Bey P. Conformity index: a review. Int J Radiat Oncol Biol Phys. 2006;64:333-42.
29. Mayo CS, Urie MM. A systematic benchmark method for analysis and comparison of IMRT treatment planning algorithms. Med Dosim. 2003;28:235-42.
30. Mock U, Bogner J, Georg D, Auberger T, Potter R. Comparative treatment planning on localized prostate carcinoma conformal photon- versus proton-based radiotherapy. Strahlenther Onkol. 2005;181:448-55.
31. Clivio A, Kluge A, Cozzi L, Koehler C, Neumann O, Vanetti E, et al. Intensity modulated proton beam radiation for brachytherapy in patients with cervical carcinoma. Int J Radiat Oncol Biol Phys. 2013;87:897-903.
32. Georg P, Poetter R, Georg D, Lang S, Dimopoulos J, Sturdza A, et al. Dose effect relationship for late side effects of the rectum and urinary bladder in magnetic resonance image-guided adaptive cervix cancer brachytherapy. Int J Radiat Oncol Biol Phys. 2010;82:653-7.
33. Dawson L, Kavanagh B, Paulino A, Shiva D, Miften M, Li A, et al. Radiation associated kidney injury. Int J Radiat Oncol Biol Phys. 2010;76:S108-15.