메뉴 건너뛰기




Volumn 14, Issue 3, 2015, Pages 391-399

Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression

Author keywords

Cellular senescence; Luciferase reporter screen; MiR 23a; Telomere dysfunction; TRF2

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 23A; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG; MIRN23 MICRORNA, HUMAN; TERF2 PROTEIN, HUMAN;

EID: 84927910828     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12304     Document Type: Article
Times cited : (51)

References (45)
  • 1
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V (2004) The functions of animal microRNAs. Nature 431, 350-355.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 3
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 4
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn EH (2001) Switching and signaling at the telomere. Cell 106, 661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 5
    • 22144490491 scopus 로고    scopus 로고
    • DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
    • Celli GB, de Lange T (2005) DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol. 7, 712-718.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 712-718
    • Celli, G.B.1    de Lange, T.2
  • 6
    • 84880509389 scopus 로고    scopus 로고
    • The telomere deprotection response is functionally distinct from the genomic DNA damage response
    • Cesare AJ, Hayashi MT, Crabbe L, Karlseder J (2013) The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol. Cell 51, 141-155.
    • (2013) Mol. Cell , vol.51 , pp. 141-155
    • Cesare, A.J.1    Hayashi, M.T.2    Crabbe, L.3    Karlseder, J.4
  • 8
    • 67649217148 scopus 로고    scopus 로고
    • Upregulation of miR-23a-27a-24-2 cluster induces caspase-dependent and -independent apoptosis in human embryonic kidney cells
    • Chhabra R, Adlakha YK, Hariharan M, Scaria V, Saini N (2009) Upregulation of miR-23a-27a-24-2 cluster induces caspase-dependent and -independent apoptosis in human embryonic kidney cells. PLoS One 4, e5848.
    • (2009) PLoS One , vol.4 , pp. e5848
    • Chhabra, R.1    Adlakha, Y.K.2    Hariharan, M.3    Scaria, V.4    Saini, N.5
  • 10
    • 34548317418 scopus 로고    scopus 로고
    • Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    • Denchi EL, de Lange T (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448, 1068-1071.
    • (2007) Nature , vol.448 , pp. 1068-1071
    • Denchi, E.L.1    de Lange, T.2
  • 11
    • 44349136891 scopus 로고    scopus 로고
    • Telomere dysfunction and tumour suppression: the senescence connection
    • Deng Y, Chan SS, Chang S (2008) Telomere dysfunction and tumour suppression: the senescence connection. Nat. Rev. Cancer 8, 450-458.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 450-458
    • Deng, Y.1    Chan, S.S.2    Chang, S.3
  • 14
    • 84885580087 scopus 로고    scopus 로고
    • Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation
    • Doksani Y, Wu JY, de Lange T, Zhuang X (2013) Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell 155, 345-356.
    • (2013) Cell , vol.155 , pp. 345-356
    • Doksani, Y.1    Wu, J.Y.2    de Lange, T.3    Zhuang, X.4
  • 15
    • 84862726635 scopus 로고    scopus 로고
    • Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells
    • Dong W, Shen R, Wang Q, Gao Y, Qi X, Jiang H, Yao J, Lin X, Wu Y, Wang L (2009) Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells. Cancer Biol. Ther. 8, 2166-2174.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 2166-2174
    • Dong, W.1    Shen, R.2    Wang, Q.3    Gao, Y.4    Qi, X.5    Jiang, H.6    Yao, J.7    Lin, X.8    Wu, Y.9    Wang, L.10
  • 16
    • 0042386051 scopus 로고    scopus 로고
    • Telomere dysfunction and the initiation of genome instability
    • Feldser DM, Hackett JA, Greider CW (2003) Telomere dysfunction and the initiation of genome instability. Nat. Rev. Cancer 3, 623-627.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 623-627
    • Feldser, D.M.1    Hackett, J.A.2    Greider, C.W.3
  • 19
    • 79956315291 scopus 로고    scopus 로고
    • MicroRegulators come of age in senescence
    • Gorospe M, Abdelmohsen K (2011) MicroRegulators come of age in senescence. Trends Genet. 27, 233-241.
    • (2011) Trends Genet. , vol.27 , pp. 233-241
    • Gorospe, M.1    Abdelmohsen, K.2
  • 20
    • 0032562649 scopus 로고    scopus 로고
    • TRF1 promotes parallel pairing of telomeric tracts in vitro
    • Griffith J, Bianchi A, de Lange T (1998) TRF1 promotes parallel pairing of telomeric tracts in vitro. J. Mol. Biol. 278, 79-88.
    • (1998) J. Mol. Biol. , vol.278 , pp. 79-88
    • Griffith, J.1    Bianchi, A.2    de Lange, T.3
  • 21
    • 0033605145 scopus 로고    scopus 로고
    • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 1321-1325.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    de Lange, T.5
  • 24
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: the protein complex that shapes and safeguards human telomeres
    • de Lange T (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19, 2100-2110.
    • (2005) Genes Dev. , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 25
    • 78651359790 scopus 로고    scopus 로고
    • Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging
    • Lee S, Jung JW, Park SB, Roh K, Lee SY, Kim JH, Kang SK, Kang KS (2011) Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging. Cell. Mol. Life Sci. 68, 325-336.
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 325-336
    • Lee, S.1    Jung, J.W.2    Park, S.B.3    Roh, K.4    Lee, S.Y.5    Kim, J.H.6    Kang, S.K.7    Kang, K.S.8
  • 26
    • 10944240539 scopus 로고    scopus 로고
    • Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
    • Liu D, O'Connor MS, Qin J, Songyang Z (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279, 51338-51342.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51338-51342
    • Liu, D.1    O'Connor, M.S.2    Qin, J.3    Songyang, Z.4
  • 28
    • 78349270933 scopus 로고    scopus 로고
    • Role of shelterin in cancer and aging
    • Martinez P, Blasco MA (2010) Role of shelterin in cancer and aging. Aging Cell 9, 653-666.
    • (2010) Aging Cell , vol.9 , pp. 653-666
    • Martinez, P.1    Blasco, M.A.2
  • 29
    • 84905046953 scopus 로고    scopus 로고
    • Essential role for the TRF2 telomere protein in adult skin homeostasis
    • Martinez P, Ferrara-Romeo I, Flores JM, Blasco MA (2014) Essential role for the TRF2 telomere protein in adult skin homeostasis. Aging Cell 13, 656-668.
    • (2014) Aging Cell , vol.13 , pp. 656-668
    • Martinez, P.1    Ferrara-Romeo, I.2    Flores, J.M.3    Blasco, M.A.4
  • 30
    • 33748587841 scopus 로고    scopus 로고
    • A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes
    • Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, Lim B, Rigoutsos I (2006) A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell 126, 1203-1217.
    • (2006) Cell , vol.126 , pp. 1203-1217
    • Miranda, K.C.1    Huynh, T.2    Tay, Y.3    Ang, Y.S.4    Tam, W.L.5    Thomson, A.M.6    Lim, B.7    Rigoutsos, I.8
  • 31
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita M, Nunez S, Heard E, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW (2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nunez, S.2    Heard, E.3    Lin, A.W.4    Hearn, S.A.5    Spector, D.L.6    Hannon, G.J.7    Lowe, S.W.8
  • 33
    • 46249125488 scopus 로고    scopus 로고
    • How shelterin protects mammalian telomeres
    • Palm W, de Lange T (2008) How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42, 301-334.
    • (2008) Annu. Rev. Genet. , vol.42 , pp. 301-334
    • Palm, W.1    de Lange, T.2
  • 34
    • 82755192899 scopus 로고    scopus 로고
    • Role of telomeres and telomerase in cancer
    • Shay JW, Wright WE (2011) Role of telomeres and telomerase in cancer. Semin. Cancer Biol. 21, 349-353.
    • (2011) Semin. Cancer Biol. , vol.21 , pp. 349-353
    • Shay, J.W.1    Wright, W.E.2
  • 35
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • van Steensel, B.1    Smogorzewska, A.2    de Lange, T.3
  • 36
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H, Smogorzewska A, de Lange T (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556.
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 38
    • 84859314596 scopus 로고    scopus 로고
    • Signalling the end of the line
    • van Tuyn J, Adams PD (2012) Signalling the end of the line. Nat. Cell Biol. 14, 339-341.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 339-341
    • van Tuyn, J.1    Adams, P.D.2
  • 39
    • 84885000772 scopus 로고    scopus 로고
    • MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma
    • Wang N, Zhu M, Tsao SW, Man K, Zhang Z, Feng Y (2013) MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. Mol. Cancer. 12, 119.
    • (2013) Mol. Cancer. , vol.12 , pp. 119
    • Wang, N.1    Zhu, M.2    Tsao, S.W.3    Man, K.4    Zhang, Z.5    Feng, Y.6
  • 41
    • 66049153398 scopus 로고    scopus 로고
    • Evolution under canalization and the dual roles of microRNAs: a hypothesis
    • Wu CI, Shen Y, Tang T (2009) Evolution under canalization and the dual roles of microRNAs: a hypothesis. Genome Res. 19, 734-743.
    • (2009) Genome Res. , vol.19 , pp. 734-743
    • Wu, C.I.1    Shen, Y.2    Tang, T.3
  • 42
    • 77951092028 scopus 로고    scopus 로고
    • Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region
    • Wu S, Huang S, Ding J, Zhao Y, Liang L, Liu T, Zhan R, He X (2010) Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region. Oncogene 29, 2302-2308.
    • (2010) Oncogene , vol.29 , pp. 2302-2308
    • Wu, S.1    Huang, S.2    Ding, J.3    Zhao, Y.4    Liang, L.5    Liu, T.6    Zhan, R.7    He, X.8
  • 43
    • 58849150874 scopus 로고    scopus 로고
    • The telosome/shelterin complex and its functions
    • Xin H, Liu D, Songyang Z (2008) The telosome/shelterin complex and its functions. Genome Biol. 9, 232.
    • (2008) Genome Biol. , vol.9 , pp. 232
    • Xin, H.1    Liu, D.2    Songyang, Z.3
  • 44
    • 84867525253 scopus 로고    scopus 로고
    • Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-beta signalling pathway
    • Zhang Y, Fan KJ, Sun Q, Chen AZ, Shen WL, Zhao ZH, Zheng XF, Yang X (2012) Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-beta signalling pathway. Nucleic Acids Res. 40, 9286-9297.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 9286-9297
    • Zhang, Y.1    Fan, K.J.2    Sun, Q.3    Chen, A.Z.4    Shen, W.L.5    Zhao, Z.H.6    Zheng, X.F.7    Yang, X.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.