Detection of persistent Plasmodium spp. infections in Ugandan children after artemether-lumefantrine treatment

Parasitology

Volumn 141, Issue 14, 2014, Pages 1880-1890

  Betson, Martha ^a   Sousa Figueiredo, José C ^b   Atuhaire, Aaron ^c   Arinaitwe, Moses ^c   Adriko, Moses ^c   Mwesigwa, Gerald ^c   Nabonge, Juma ^d   Kabatereine, Narcis B ^c   Sutherland, Colin J ^b   Stothard, J Russell ^e  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c MINISTRY OF HEALTH   (Uganda)

^d Vector Control Division   (Uganda)

^e LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

artemisinin combination therapy; malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodium ovale; rapid diagnostic test; Uganda

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; QUININE; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ DERIVATIVE; BENFLUMETOL; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE;

ANEMIA; ARTICLE; AXILLA TEMPERATURE; BLOOD; CHILD; DIAGNOSTIC PROCEDURE; DISEASE CARRIER; FEMALE; FEVER; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALARIA; MALARIA FALCIPARUM; MALE; MICROSCOPY; OBSERVATIONAL STUDY; PARASITEMIA; PILOT STUDY; PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM MALARIAE INFECTION; PLASMODIUM OVALE MALARIA; POINT OF CARE TESTING; PREVALENCE; PRIORITY JOURNAL; RAPID ANTIGEN TEST; REAL TIME POLYMERASE CHAIN REACTION; SHORT COURSE THERAPY; UGANDAN; COMBINATION DRUG THERAPY; DIAGNOSTIC TEST; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MIXED INFECTION; PARASITOLOGY; PLASMODIUM; PLASMODIUM OVALE; POINT OF CARE SYSTEM; PRESCHOOL CHILD; UGANDA;

PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE;

ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; COINFECTION; DIAGNOSTIC TESTS, ROUTINE; DRUG THERAPY, COMBINATION; ETHANOLAMINES; FEMALE; FLUORENES; FOLLOW-UP STUDIES; HUMANS; LONGITUDINAL STUDIES; MALARIA; MALE; PLASMODIUM; PLASMODIUM FALCIPARUM; PLASMODIUM OVALE; POINT-OF-CARE SYSTEMS; PREVALENCE; UGANDA;

EID: 84927909230     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S003118201400033X     Document Type: Article

References (19)

1. Achan, J., Tibenderana, J. K., Kyabayinze, D., Wabwire Mangen, F., Kamya, M. R., Dorsey, G., D'Alessandro, U., Rosenthal, P. J. and Talisuna, A. O. (2009). Effectiveness of quinine versus artemetherlumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. British Medical Journal 339, b2763.
2. Arinaitwe, E., Sandison, T. G., Wanzira, H., Kakuru, A., Homsy, J., Kalamya, J., Kamya, M. R., Vora, N., Greenhouse, B., Rosenthal, P. J., Tappero, J. and Dorsey, G. (2009). Artemetherlumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clinical Infectious Diseases 49, 1629-1637.
3. Aydin-Schmidt, B., Mubi, M., Morris, U., Petzold, M., Ngasala, B. E., Premji, Z., Bjorkman, A. and Martensson, A. (2013). Usefulness of Plasmodium falciparum-specific rapid diagnostic tests for assessment of parasite clearance and detection of recurrent infections after artemisininbased combination therapy. Malaria Journal 12, 349.
4. Baliraine, F. N. and Rosenthal, P. J. (2011). Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemetherlumefantrine in Uganda. Journal of Infectious Diseases 204, 1120-1124.
5. Bassat, Q., Mulenga, M., Tinto, H., Piola, P., Borrmann, S., Menendez, C., Nambozi, M., Valea, I., Nabasumba, C., Sasi, P., Bacchieri, A., Corsi, M., Ubben, D., Talisuna, A. and D'Alessandro, U. (2009). Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial. PLoS One 4, e7871.
6. Batwala, V., Magnussen, P. and Nuwaha, F. (2010). Challenges to implementation of artemisinin combination therapy policy in Uganda. International Health 2, 262-268.
7. Beshir, K. B., Sutherland, C. J., Sawa, P., Drakeley, C. J., Okell, L., Mweresa, C. K., Omar, S. A., Shekalaghe, S. A., Kaur, H., Ndaro, A., Chilongola, J., Schallig, H. D., Sauerwein, R.W., Hallett, R. L. and Bousema, T. (2013). Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence. Journal of Infectious Diseases 208, 2017-2024.
8. Betson, M., Sousa-Figueiredo, J. C., Rowell, C., Kabatereine, N. B. and Stothard, J. R. (2010). Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity. American Journal of Tropical Medicine and Hygiene 83, 1048-1055.
9. Borrmann, S., Sasi, P., Mwai, L., Bashraheil, M., Abdallah, A., Muriithi, S., Fruhauf, H., Schaub, B., Pfeil, J., Peshu, J., Hanpithakpong, W., Rippert, A., Juma, E., Tsofa, B., Mosobo, M., Lowe, B., Osier, F., Fegan, G., Lindegardh, N., Nzila, A., Peshu, N., Mackinnon, M. and Marsh, K. (2011). Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast. PLoS One 6, e26005.
10. Bruce, M. C., Macheso, A., Kelly-Hope, L. A., Nkhoma, S., McConnachie, A. and Molyneux, M. E. (2008). Effect of transmission setting and mixed species infections on clinical measures of malaria in Malawi. PLoS One 3, e2775.
11. Bukirwa, H., Yeka, A., Kamya, M. R., Talisuna, A., Banek, K., Bakyaita, N., Rwakimari, J. B., Rosenthal, P. J., Wabwire-Mangen, F., Dorsey, G. and Staedke, S. G. (2006). Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clinical Trials 1, e7.
12. Collins, W. E. and Jeffery, G. M. (2005). Plasmodium ovale: parasite and disease. Clinical Microbiology Reviews 18, 570-581.
13. Collins, W. E. and Jeffery, G. M. (2007). Plasmodium malariae: parasite and disease. Clinical Microbiology Reviews 20, 579-592.
14. Dinko, B., Oguike, M. C., Larbi, J. A., Bousema, T. and Sutherland, C. J. (2013). Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian school-children. International Journal for Parasitology: Drugs and Drug Resistance 3, 45-50.
15. Dlamini, S. V., Beshir, K. and Sutherland, C. J. (2010). Markers of antimalarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates. Malaria Journal 9, 68.
16. Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., Ringwald, P., Silamut, K., Imwong, M., Chotivanich, K., Lim, P., Herdman, T., An, S. S., Yeung, S., Singhasivanon, P., Day, N. P., Lindegardh, N., Socheat, D. and White, N. J. (2009). Artemisinin resistance in Plasmodium falciparum malaria. New England Journal of Medicine 361, 455-467.
17. Dorsey, G., Staedke, S., Clark, T. D., Njama-Meya, D., Nzarubara, B., Maiteki-Sebuguzi, C., Dokomajilar, C., Kamya, M. R. and Rosenthal, P. J. (2007). Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. Journal of the American Medical Association 297, 2210-2219.
18. Drakeley, C. and Reyburn, H. (2009). Out with the old, in with the new: the utility of rapid diagnostic tests for malaria diagnosis in Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 103, 333-337.
19. Felger, I. and Snounou, G. (2008). Recommended Genotyping Procedures (RGPs) to Identify Parasite Populations. Medicine for Malaria Venture and World Health Organization, Geneva, Switzerland.