Risk factors for small-bowel mucosal breaks in chronic low-dose aspirin users: Data from a prospective multicenter capsule endoscopy registry

Gastrointestinal Endoscopy

Volumn 80, Issue 5, 2014, Pages 826-834

  Endo, Hiroki ^a   Sakai, Eiji ^a   Taniguchi, Leo ^b   Kessoku, Takaomi ^c   Komiya, Yasuhiko ^d   Ezuka, Akiko ^d   Kawamura, Harunobu ^e   Taguri, Masataka ^f   Higurashi, Takuma ^a   Ohkubo, Hidenori ^a   Yamada, Eiji ^a   Takahashi, Hirokazu ^a   Inamori, Masahiko ^a   Maeda, Shin ^a   Sakaguchi, Takashi ^c   Hata, Yasuo ^b   Nagase, Hajime ^d   Nakajima, Atsushi ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b CHIGASAKI MUNICIPAL HOSPITAL   (Japan)

^c Hiratsuka City Hospital   (Japan)

^d YOKOHAMA ROSAI HOSPITAL   (Japan)

^e Odawara Municipal Hospital   (Japan)

^f YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; PROTON PUMP INHIBITOR; ANTITHROMBOCYTIC AGENT; ENTERIC COATED TABLET;

AGED; ARTICLE; CAPSULE ENDOSCOPE; CAPSULE ENDOSCOPY; FEMALE; GASTROINTESTINAL ENDOSCOPY; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SMALL INTESTINE; CARDIOVASCULAR DISEASES; CLINICAL TRIAL; CROSS-SECTIONAL STUDY; ENTERIC COATED TABLET; INTESTINE MUCOSA; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; PATHOLOGY; PEPTIC ULCER; PROSPECTIVE STUDY; REGISTER; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ASPIRIN; CAPSULE ENDOSCOPY; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PEPTIC ULCER; PLATELET AGGREGATION INHIBITORS; PROSPECTIVE STUDIES; PROTON PUMP INHIBITORS; REGISTRIES; TABLETS, ENTERIC-COATED;

EID: 84927798820     PISSN: 00165107     EISSN: 10976779     Source Type: Journal    
DOI: 10.1016/j.gie.2014.03.024     Document Type: Article

References (27)

1. Awtry EH, Loscalzo J. Aspirin. Circulation 2000;101:1206-18.
2. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324: 71-86.
3. Patrono C, García Rodríguez LA, Landolfi R, et al. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med 2005;353:2373-83.
4. Weil J, Colin-Jones D, Langman M, et al. Prophylactic aspirin and risk of peptic ulcer bleeding. BMJ 1995;310:827-30.
5. Patrono C. Aspirin as an antiplatelet drug. N Engl J Med 1994;330: 1287-94.
6. Endo H, Hosono K, Inamori M, et al. Incidence of small bowel injury induced by low-dose aspirin: A crossover study using capsule endoscopy in healthy volunteers. Digestion 2009;79:44-51.
7. Endo H, Hosono K, Inamori M, et al. Characteristics of small bowel injury in symptomatic chronic low-dose aspirin users: The experience of two medical centers in capsule endoscopy. J Gastroenterol 2009;44:544-9.
8. Matsumoto T, Kudo T, Esaki M, et al. Prevalence of non-steroidal anti-inflammatory drug-induced enteropathy determined by doubleballoon endoscopy: A Japanese multicenter study. Scand J Gastroenterol 2008;43:490-6.
9. Manetas M, O'Loughlin C, Kelemen K, et al. Multiple small-bowel diaphragms: A cause of obscure GI bleeding diagnosed by capsule endoscopy. Gastrointest Endosc 2004;60:848-51.
10. Lanas A, Scheiman J. Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment. Curr Med Res Opin 2007;23:163-73.
11. Graham DY, Opekun AR, Willingham FF, et al. Visible small-intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol 2005;3:55-9.
12. Gralnek IM, Defranchis R, Seidman E, et al. Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Aliment Pharmacol Ther 2008;27:146-54.
13. Endo H, Hosono K, Higurashi T, et al. Quantitative of low-dose aspirinassociated small bowel injury using a capsule endoscopy scoring index. Dig Endosc 2011;23:56-61.
14. Arora G, Singh G, Triadafilopoulos G. Proton pump inhibitor for gastroduodenal damage related to nonsteroidal anti-inflammatory drugs or aspirin: Twelve important questions for clinical practice. Clin Gastroenterol Hepatol 2009;7:725-35.
15. Konaka A, Kato S, Tanaka A, et al. Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats. Pharmacologic Res 1999;40:517-24.
16. Watanabe T, Nishio H, Tanigawa T, et al. Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid. Am J Physiol Gastrointest Liver Physiol 2009;297:506-13.
17. Watanabe T, Higuchi K, Kobata A, et al. Non-steroidal antiinflammatory drug-induced small intestinal damage is toll-like receptor 4 dependent. Gut 2008;57:181-7.
18. Lombardo L, Foti M, Ruggia O, et al. Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy. Clin Gastroenterol Hepatol 2010;8:504-8.
19. Compare D, Pica L, Rocco A, et al. Effects of long-term PPI treatment on producing bowel symptoms and SIBO. Eur J Clin Invest 2011;41: 380-6.
20. Wallace JL, Syer S, Denou E, et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dyspoiesis. Gastroenterology 2011;114:1314-22.
21. Endo H, Higurashi T, Hosono K, et al. Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: A pilot randomized controlled study. J Gastroenterol 2011;46:894-905.
22. Yoda Y, Amagase K, Kato S, et al. Prevention by lansoprazole, a proton pump inhibitor, of indomethacin-induced small intestinal ulceration in rats through induction of heme oxygenase-1. J Physiol Pharmacol 2010;61:287-94.
23. Higuchi K, Yoda Y, Amagase K, et al. Prevention of NSAID-induced small bowel intestinal mucosal injury: prophylactic potential of lansoprazole. J Clin Biochem Nutr 2009;45:125-30.
24. Thorens J, Froehlich F, Schwizer W, et al. Bacterial overgrowth during treatment with omeprazole compared with cimetidine: A prospective randomised double blind study. Gut 1996;39:54-9.
25. Hoftiezer JW, Silvoso GR, Burks M, et al. Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man. Lancet 1980;2:609-12.
26. Endo H, Sakai E, Higurashi T, et al. Differences in the severity of small bowel mucosal injury based on the type of aspirin as evaluated by capsule endoscopy. Dig Liver Dis 2012;44:833-8.
27. Cryer B, Feldman M. Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans. Gastroenterology 1999;117:17-25.