Rising post-colectomy complications in children with ulcerative colitis despite stable colectomy rates in United States

Journal of Crohn's and Colitis

Volumn 8, Issue 11, 2014, Pages 1417-1426

  Soon, Ing Shian ^a   deBruyn, Jennifer C C ^a   Hubbard, James ^a   Wrobel, Iwona ^a   Sauve, Reg ^a   Sigalet, David L ^a   Kaplan, Gilaad G ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Children; Colectomy; Kids' Inpatient Database; Postoperative complications; Ulcerative colitis

Indexed keywords

ACUTE HEART INFARCTION; ACUTE KIDNEY FAILURE; ACUTE RESPIRATORY FAILURE; ADOLESCENT; ADULT; ARTICLE; ATELECTASIS; BACTEREMIA; CHILD; CHILDHOOD DISEASE; COLON FISTULA; COLON RESECTION; DEEP VEIN THROMBOSIS; FEMALE; HEART ARREST; HEART FAILURE; HEMATOMA; HOSPITAL CHARGE; HUMAN; INFANT; LENGTH OF STAY; LIVER FAILURE; LUNG EDEMA; MAJOR CLINICAL STUDY; MALE; PANCREATITIS; PEDIATRIC SURGERY; PNEUMONIA; POSTOPERATIVE COMPLICATION; POSTOPERATIVE ILEUS; POSTOPERATIVE INFECTION; POSTOPERATIVE NAUSEA; POSTOPERATIVE VOMITING; PRESCHOOL CHILD; PRIORITY JOURNAL; PRIVATE HEALTH INSURANCE; SEPSIS; SHOCK; SMALL INTESTINE OBSTRUCTION; ULCERATIVE COLITIS; UNITED STATES; URBAN AREA; URINARY TRACT INFECTION; URINE RETENTION; WOUND DEHISCENCE; ADVERSE EFFECTS; COLITIS, ULCERATIVE; EMERGENCY; INCIDENCE; INFECTION; NEWBORN; RISK FACTOR; STATISTICS AND NUMERICAL DATA; TRENDS;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COLECTOMY; COLITIS, ULCERATIVE; EMERGENCIES; FEMALE; HOSPITAL CHARGES; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; INFECTION; LENGTH OF STAY; MALE; RISK FACTORS; UNITED STATES;

EID: 84927797828     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2014.05.002     Document Type: Article

References (36)

1. Molodecky N.A., Soon I.S., Rabi D.M., Ghali W.A., Ferris M., Chernoff G., et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology Jan 2012, 142(1):46-54. [e42; quiz e30].
2. Frolkis A.D., Dykeman J., Negrón M.E., Debruyn J., Jette N., Fiest K.M., et al. Risk of surgery for inflammatory bowel diseases has decreased over time: a systematic review and meta-analysis of population-based studies. Gastroenterology Nov 2013, 145(5):996-1006.
3. Soon I.S., Wrobel I., deBruyn J.C., Sauve R., Sigalet D.L., Kaplan B.S., et al. Postoperative complications following colectomy for ulcerative colitis in children. J Pediatr Gastroenterol Nutr Jun 2012, 54(6):763-768.
4. Kaplan G.G., Seow C.H., Ghosh S., Molodecky N., Rezaie A., Moran G.W., et al. Decreasing colectomy rates for ulcerative colitis: a population-based time trend study. Am J Gastroenterol Dec 2012, 107(12):1879-1887.
5. El-Baba M., Lin C.H., Klein M., Tolia V. Outcome after surgical intervention in children with chronic inflammatory bowel disease. Am Surg Dec 1996, 62(12):1014-1017.
6. Rintala R.J., Lindahl H.G. Proctocolectomy and J-pouch ileo-anal anastomosis in children. J Pediatr Surg Jan 2002, 37(1):66-70.
7. Patton D., Gupta N., Wojcicki J.M., Garnett E.A., Nobuhara K., Heyman M.B. Postoperative outcome of colectomy for pediatric patients with ulcerative colitis. J Pediatr Gastroenterol Nutr Aug 2010, 51(2):151-154.
8. Sako M., Kimura H., Arai K., Koganei K., Kito F., Sugita A., et al. Restorative proctocolectomy for pediatric patients with ulcerative colitis. Surg 2006, 36(2):162-165.
9. Pakarinen M.P., Natunen J., Ashorn M., Koivusalo A., Turunen P., Rintala R.J., et al. Long-term outcomes of restorative proctocolectomy in children with ulcerative colitis. Pediatrics May 2009, 123(5):1377-1382.
10. de Silva S., Ma C., Proulx M.C., Crespin M., Kaplan B.S., Hubbard J., et al. Postoperative complications and mortality following colectomy for ulcerative colitis. Clin Gastroenterol Hepatol 2011, 9(11):972-980.
11. Agency for Healthcare Quality, Research KID database documentation Available at:, [Accessed Jan 8, 2012]. http://www.hcup-us.ahrq.gov/kidoverview.jsp.
12. Heaton P., Tundia N., Schmidt N., Wigle P., Kelton C. National burden of pediatric hospitalizations for inflammatory bowel disease: results from the 2006 Kids' Inpatient Database. J Pediatr Gastroenterol Nutr Apr 2012, 54(4):477-485. 10.1097/MPG.1090b1013e318239bc318279.
13. Debruyn J., Soon I., Hubbard J., Wrobel I., Panaccione R., Kaplan G. Nationwide temporal trends in incidence of hospitalization and surgical intestinal resection in pediatric inflammatory bowel diseases in the United States from 1997 to 2009. Inflamm Bowel Dis Oct 2013, 19(11):2423-2432. 10.1097/MIB.2420b2013e3182a56148.
14. Ma C., Crespin M., Proulx M.C., DeSilva S., Hubbard J., Prusinkiewicz M., et al. Postoperative complications following colectomy for ulcerative colitis: a validation study. BMC Gastroenterol 2012, 12:39.
15. U.S.Bureau of the Census Available at:, [Accessed December 11, 2011]. http://www.census.gov/popest/index.html.
16. United States Department of Labor.Bureau of Labor Statistics Consumer price index Available at:, [Accessed December 11, 2011]. http://www.bls.gov/cpi/.
17. Stata Statistical Software 2009, Stata Corporation, College Station (TX).
18. Cosnes J., Gower-Rousseau C., Seksik P., Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 2011, 140(6):1785-1794. [e1784].
19. Falcone R.A., Lewis L.G., Warner B.W. Predicting the need for colectomy in pediatric patients with ulcerative colitis. J Gastrointest Surg Mar-Apr 2000, 4(2):201-206.
20. Gower-Rousseau C., Dauchet L., Vernier-Massouille G., Tilloy E., Brazier F., Merle V., et al. The natural history of pediatric ulcerative colitis: a population-based cohort study. Am J Gastroenterol Aug 2009, 104(8):2080-2088.
21. Van Limbergen J., Russell R.K., Drummond H.E., Aldhous M.C., Round N.K., Nimmo E.R., et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology Oct 2008, 135(4):1114-1122.
22. Sandborn W.J., Rutgeerts P., Feagan B.G., Reinisch W., Olson A., Johanns J., et al. Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab. Gastroenterology Oct 2009, 137(4):1250-1260. [quiz 1520].
23. Williet N., Pillot C., Oussalah A., Billioud V., Chevaux J.B., Bresler L., et al. Incidence of and impact of medications on colectomy in newly diagnosed ulcerative colitis in the era of biologics. Inflamm Bowel Dis Sep 2012, 18(9):1641-1646.
24. Kaplan G.G., McCarthy E.P., Ayanian J.Z., Korzenik J., Hodin R., Sands B.E. Impact of hospital volume on postoperative morbidity and mortality following a colectomy for ulcerative colitis. Gastroenterology Mar 2008, 134(3):680-687.
25. Kaplan G.G., Hubbard J., Panaccione R., Shaheen A.A., Quan H., Nguyen G.C., Dixon E., et al. Risk of comorbidities on postoperative outcomes in patients with inflammatory bowel disease. Arch Surg Aug 2011, 146(8):959-964.
26. Randall J., Singh B., Warren B.F., Travis S.P.L., Mortensen N.J., George B.D. Delayed surgery for acute severe colitis is associated with increased risk of postoperative complications. Br J Surg Mar 2010, 97(3):404-409.
27. Nelson R., Liao C., Fichera A., Rubin D.T., Pekow J. Rescue therapy with cyclosporine or infliximab is not associated with an increased risk for postoperative complications in patients hospitalized for severe steroid-refractory ulcerative colitis. Inflamm Bowel Dis Jan 2014, 20(1):14-20. 10.1097/1001.MIB.0000437497.0000407181.0000437405.
28. Kennedy R., Potter D.D., Moir C., Zarroug A.E., Faubion W., Tung J. Pediatric chronic ulcerative colitis: does infliximab increase post-ileal pouch anal anastomosis complications?. J Pediatr Surg Jan 2012, 47(1):199-203.
29. Yang Z., Wu Q., Wang F., Wu K., Fan D. Meta-analysis: effect of preoperative infliximab use on early postoperative complications in patients with ulcerative colitis undergoing abdominal surgery. Aliment Pharmacol Ther Nov 2012, 36(10):922-928. [Epub 12012 Sep 12024]. 10.1111/apt.12060.
30. Adamiak T., Walkiewicz-Jedrzejczak D., Fish D., Brown C., Tung J., Khan K., et al. Incidence, clinical characteristics, and natural history of pediatric IBD in Wisconsin: a population-based epidemiological study. Inflamm Bowel Dis 2013, 19(6):1218-1223. 10.1097/MIB.1210b1013e318280b318213e.
31. Kappelman M., Moore K., Allen J., Cook S. Recent trends in the prevalence of Crohn's disease and ulcerative colitis in a commercially insured US population. Dig Dis Sci 2013, 58(2):519-525. [2013/02/01].
32. Molodecky N.A., Panaccione R., Ghosh S., Barkema H.W., Kaplan G.G. Challenges associated with identifying the environmental determinants of the inflammatory bowel diseases. Inflamm Bowel Dis Aug 2011, 17(8):1792-1799.
33. Guller U., Jain N., Hervey S., Purves H., Pietrobon R. Laparoscopic vs open colectomy: outcomes comparison based on large nationwide databases. Arch Surg Nov 2003, 138(11):1179-1186.
34. Guller U., Hervey S., Purves H., Muhlbaier L.H., Peterson E.D., Eubanks S., et al. Laparoscopic versus open appendectomy: outcomes comparison based on a large administrative database. Ann Surg Jan 2004, 239(1):43-52.
35. Khan N.A., Quan H., Bugar J.M., Lemaire J.B., Brant R., Ghali W.A. Association of postoperative complications with hospital costs and length of stay in a tertiary care center. J Gen Intern Med Feb 2006, 21(2):177-180.
36. Lawthers A.G., McCarthy E.P., Davis R.B., Peterson L.E., Palmer R.H., Iezzoni L.I. Identification of in-hospital complications from claims data. Is it valid?. Med Care Aug 2000, 38(8):785-795.