The combined risk of donor quality and recipient age: Higher-quality kidneys may not always improve patient and graft survival

Transplantation

Volumn 98, Issue 10, 2014, Pages 1069-1076

  Hernandez, Roland A ^a,b   Malek, Sayeed K ^a   Milford, Edgar L ^a   Finlayson, Samuel R G ^c   Tullius, Stefan G ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

KDPI; Organ quality; Recipient age

Indexed keywords

ADULT; AGE; AGED; ARTICLE; COHORT ANALYSIS; DEATH; DISEASE ASSOCIATION; ETHNICITY; FEMALE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; KIDNEY DONOR; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OVERALL SURVIVAL; PRIORITY JOURNAL; QUALITY CONTROL; RISK ASSESSMENT; SURVIVAL RATE; YOUNG ADULT; ADOLESCENT; ADVERSE EFFECTS; DONOR; EPIDEMIOLOGY; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MORTALITY; RISK FACTOR; STATISTICS AND NUMERICAL DATA; SURVIVAL; UNITED STATES; VERY ELDERLY;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; GRAFT SURVIVAL; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; RISK FACTORS; SURVIVAL ANALYSIS; TISSUE DONORS; UNITED STATES; YOUNG ADULT;

EID: 84927786167     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000181     Document Type: Article

References (18)

1. Knoll GA. Is kidney transplantation for everyone? The example of the older dialysis patient. Clin J Am Soc Nephrol 2009;4:2040.
2. Wolfe RA, Ashby VB, Milford EL, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999;341:1725.
3. U. S. Renal Data System, USRDS 2011. Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of diabetes and Digestive and Kidney Disease, Bethesda, MD, 2011.
4. Rao PS, Merion RM, Ashby VB, et al. Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation 2007;83:1069.
5. Sung RS, Guidinger MK, Leichtman AB, et al. Impact of the expanded criteria donor allocation system on candidates for and recipients of expanded criteria donor kidneys. Transplantation 2007;84:1138.
6. OPTN/UNOS. Kidney Transplantation Committee Report to the Board of Directors. Saint Louis, MO, 2012.
7. Rao PS, Schaubel DE, Guiding MK, et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation 2009;88:231.
8. Metzger RA, Delmonico FL, Feng S, et al. Expanded criteria donors for kidney transplantation. Am J Transplant 2003;3(Suppl 4):114.
9. OPTN/UNOS Board approved significant revisions to deceased donor kidney allocation policy. OPTN Press Release. June 25, 2013. Available at: http://optn. transplant.hrsa.gov/news/newsDetail.asp?id=1600 (Accessed 9/19/2013).
10. Chavalitdhamrong D, Gill J, Takemoto S, et al. Patient and graft outcomes from deceased donors age 70 years and older: an analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing database. Transplantation 2008;85:1573.
11. Tullius SG, Tran H, Guleria I, et al. The combination of donor and recipient age is critical in determining host immunoresponsiveness and renal transplant outcome. Ann Surg 2010;252:662.
12. Tullius SG, Milford E. Kidney allocation and the aging immune response. N Engl J Med. 2011;364:1369.
13. Heaphy EL, Goldfarb DA, Poggio ED, et al. The impact of deceased donor kidney risk significantly varies by recipient characteristics. Am J Transplant 2013;13:1001.
14. Van Wagner LB, Skaro AI. Program-specific reports: implications and impact on program behavior. Curr Opin Organ Transplant 2013;18:210.
15. Stewart D, Samana C, Cherikh, et al. Has displaying KDPI in DonorNet led to a spike in discard rates for lower quality kidneys? American Transplant Congress Meeting Abstracts. Abstract number 301. Am J Transplant 2013;13.
16. Macrae J, Friedman AL, Friedman EA, et al. Live and deceased donor kidney transplantation in patients aged 75 years and older in the United States. Int Urol Nephrol 2005;37:641.
17. Humar A, Denny R, Matas AJ, et al. Graft and quality of life outcomes in older recipients of a kidney transplant. Exp Clin Transplant 2003;1:69.
18. Dukes JL, Seelam S, Lentine KL, et al. Health-related quality of life in kidney transplant patients with diabetes. Clin Transplant 2013.