Paclitaxel and carboplatin in patients with completely or optimally resected carcinosarcoma of the uterus : A phase II trial by the Japanese uterine sarcoma group and the tohoku gynecologic cancer unit

International Journal of Gynecological Cancer

Volumn 25, Issue 1, 2015, Pages 92-97

  Otsuki, Ai ^a   Watanabe, Yoh ^a,b   Nomura, Hiroyuki ^c   Futagami, Masayuki ^d   Yokoyama, Yoshihito ^d   Shibata, Kiyosumi ^e   Kamoi, Seiryu ^f   Arakawa, Atsushi ^g   Nishiyama, Hiroshi ^h   Katsuta, Takahiro ⁱ   Kudaka, Wataru ^j   Shimada, Muneaki ^k   Sato, Naoki ^l   Kotera, Kouhei ^m   Katabuchi, Hidetaka ⁿ   Yaegashi, Nobuo ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d HIROSAKI UNIVERSITY   (Japan)

^e NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f NIPPON MEDICAL SCHOOL CHIBA HOKUSOH HOSPITAL   (Japan)

^g NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^h FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

ⁱ FUKUOKA UNIVERSITY HOSPITAL   (Japan)

^j UNIVERSITY OF THE RYUKYUS   (Japan)

^k TOTTORI UNIVERSITY   (Japan)

^l AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^m Department of Obstetrics and Gynecology Nagasaki Harbour Medical Center City Hospital ^*  (Japan)

ⁿ KUMAMOTO UNIVERSITY   (Japan)

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Author keywords

Adjuvant chemotherapy; Phase II trial; Uterine carcinosarcoma

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBOPLATIN; CISPLATIN; DEXAMETHASONE; DIPHENHYDRAMINE; HEMOGLOBIN; IFOSFAMIDE; PACLITAXEL; RANITIDINE; ANTINEOPLASTIC AGENT;

ADJUVANT THERAPY; ADULT; AGED; ALOPECIA; ANOREXIA; ARTICLE; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER PATIENT; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CARCINOSARCOMA; CHEMOTHERAPY INDUCED ANEMIA; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SCREENING; DRUG WITHDRAWAL; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FOLLOW UP; GRANULOCYTE; GRANULOCYTOPENIA; HUMAN; HYPERTENSION; JAPANESE (PEOPLE); LEUKOCYTE; LEUKOPENIA; LIVER TOXICITY; MOTOR NEUROPATHY; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PARAAORTIC LYMPH NODE; PHASE 2 CLINICAL TRIAL; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; SENSORY NEUROPATHY; SIDE EFFECT; THROMBOCYTE; THROMBOCYTOPENIA; UTERINE CARCINOSARCOMA; UTERUS SARCOMA; UTERUS SURGERY; CANCER STAGING; CLINICAL TRIAL; FEASIBILITY STUDY; HYSTERECTOMY; LYMPH NODE DISSECTION; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PROGNOSIS; SURVIVAL RATE; UTERINE NEOPLASMS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CARCINOSARCOMA; COMBINED MODALITY THERAPY; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYSTERECTOMY; LYMPH NODE EXCISION; MIDDLE AGED; NEOPLASM STAGING; PACLITAXEL; PROGNOSIS; PROSPECTIVE STUDIES; SURVIVAL RATE; UTERINE NEOPLASMS;

EID: 84927729340     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0000000000000302     Document Type: Article

References (14)

1. National Comprehensive Cancer Network Guidelines for Treatment of Cancer. http://www.nccn.org/professionals/physician-gls/pdf/cervical.pdf. Accessed May 27, 2014.
2. Sutton G, Brunetto VL, Kilgore L, et al. A phase III trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus: A Gynecologic Oncology Group study. Gynecol Oncol. 2000;79:147-153.
3. Homesley HD, Filiaci V, Markman M, et al. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: A Gynecologic Oncology Group study. J Clin Oncol. 2007;25:526-531.
4. Galaal K, van der Heijden E, Godfrey K, et al. Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma. Cochrane Database Syst Rev. 2013;2: CD006812.
5. Sutton G, Kauderer J, Carson LF, et al. Adjuvant ifosfamide and cisplatin in patients with completely resected stage I or II carcinosarcomas (mixed mesodermal tumors) of the uterus: A Gynecologic Oncology Group study. Gynecol Oncol. 2005;96: 630-634.
6. Toyoshima M, Akahira J, Matsunaga G, et al. Clinical experience with combination paclitaxel and carboplatin therapy for advanced or recurrent carcinosarcoma of the uterus. Gynecol Oncol. 2004;94:774-778.
7. Takano T, Otsuki T, Tokunaga H, et al. Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: The Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit study. Int J Clin Oncol. 2014; doi:10.1007/s10147-013-0658-y.
8. Shepherd JH. Revised FIGO staging for gynaecological cancer. Br J Obstet Gynaecol. 1989;96:889-892.
9. National Cancer Institute Common Terminology Criteria, version 3.0. http://ctep.cancer.gov/protocolDevelopment/electronic-applications/docs/ctcaev3.pdf.
10. Hoskins PJ, Le N, Ellard S, et al. Carboplatin plus paclitaxel for advanced or recurrent uterine malignant mixed mullerian tumors. The British Columbia Cancer Agency experience. Gynecol Oncol. 2008;108:58-62.
11. Ang JE, Shah RN, Everard M, et al. A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma. Ann Oncol. 2009;20:1787-1793.
12. Matsuo K, Bond VK, Im DK, et al. Prediction of chemotherapy response with platinum and taxane in the advanced stage of ovarian and uterine carcinosarcoma: A clinical implication of in vitro drug resistance assay. Am J Clin Oncol. 2010;33:358-363.
13. Powell MA, Filiaci VL, Rose PG, et al. Phase II evaluation of paclitaxel and carboplatin in the treatment of carcinosarcoma of the uterus: A Gynecologic Oncology Group study. J Clin Oncol. 2010;28:2727-2731.
14. Lacour RA, Euscher E, Atkinson EN, et al. A phase II trial of paclitaxel and carboplatin in women with advanced or recurrent uterine carcinosarcoma. Int J Gynecol Cancer. 2011;21: 517-522.