Rationale of mesenchymal stem cell therapy in kidney injury

Nephron - Clinical Practice

Volumn 127, Issue 1-4, 2014, Pages 75-80

  Fleig, Susanne V ^a,d   Humphreys, Benjamin D ^a,b,c,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Acute kidney injury; Kidney repair; Mesenchymal stem cells; Microvesicles; Renal tubules; Tissue repair

Indexed keywords

ACUTE KIDNEY FAILURE; CELL PROTECTION; CLINICAL TRIAL (TOPIC); CONFERENCE PAPER; HEALTH SURVEY; HUMAN; KIDNEY INJURY; MESENCHYMAL STEM CELL TRANSPLANTATION; NEPHROLOGY; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; THERAPY EFFECT; ACUTE KIDNEY INJURY; ANIMAL; DISEASE MODEL; EXOSOME; FORECASTING; KIDNEY; MESENCHYMAL STROMA CELL; META ANALYSIS (TOPIC); PARACRINE SIGNALING; PHYSIOLOGY; REGENERATION; RENAL INSUFFICIENCY, CHRONIC; REPERFUSION INJURY; SECRETION (PROCESS); VASCULARIZATION;

ANGIOGENIC PROTEIN; CYTOKINE; SIGNAL PEPTIDE;

ACUTE KIDNEY INJURY; ANGIOGENIC PROTEINS; ANIMALS; CLINICAL TRIALS AS TOPIC; CYTOKINES; DISEASE MODELS, ANIMAL; EXOSOMES; FORECASTING; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; META-ANALYSIS AS TOPIC; PARACRINE COMMUNICATION; REGENERATION; RENAL INSUFFICIENCY, CHRONIC; REPERFUSION INJURY;

EID: 84927714943     PISSN: None     EISSN: 16602110     Source Type: Journal    
DOI: 10.1159/000363680     Document Type: Conference Paper

References (19)

1. Humphreys BD, Bonventre JV: Mesenchymal stem cells in acute kidney injury. Annu Rev Med 2008; 59: 311-325.
2. Bianco P, et al: The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med 2013; 19: 35-42.
3. Wang Y, et al: Systematic review and metaanalysis of mesenchymal stem/stromal cells therapy for impaired renal function in small animal models. Nephrology (Carlton) 2013; 18: 201-208.
4. Bi B, et al: Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol 2007; 18: 2486-2496.
5. Cheng K, et al: Transplantation of bone marrow-derived MSCs improves cisplatinum-induced renal injury through paracrine mechanisms. Exp Mol Pathol 2013; 94: 466-473.
6. Chen L, et al: Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008; 3:e1886.
7. Bruno S, et al: Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One 2012; 7:e33115.
8. Bruno S, et al: Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009; 20: 1053-1067.
9. Gatti S, et al: Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol Dial Transplant 2011; 26: 1474-1483.
10. Imberti B, et al: Insulin-like growth factor-1 sustains stem cell mediated renal repair. J Am Soc Nephrol 2007; 18: 2921-2928.
11. Tomasoni S, et al: Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells. Stem Cells Dev 2013; 22: 772-780.
12. Kilpinen L, et al: Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning. J Extracell Vesicles 2013; 2, DOI: 10.3402/jev.v2i0.21927.
13. Perico N, et al: Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility. Clin J Am Soc Nephrol 2011; 6: 412-422.
14. Perico N, et al: Mesenchymal stromal cells and kidney transplantation: pretransplant infusion protects from graft dysfunction while fostering immunoregulation. Transpl Int 2013; 26: 867-878.
15. Reinders ME, et al: Autologous bone marrowderived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study. Stem Cells Transl Med 2013; 2: 107-111.
16. Tan J, et al: Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA 2012; 307: 1169-1177.
17. Togel FE, Westenfelder C: Kidney protection and regeneration following acute injury: progress through stem cell therapy. Am J Kidney Dis 2012; 60: 1012-1022.
18. Breitbach M, et al: Potential risks of bone marrow cell transplantation into infarcted hearts. Blood 2007; 110: 1362-1369.
19. Kunter U, et al: Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes. J Am Soc Nephrol 2007; 18: 1754-1764.