Community-acquired Acinetobacter baumannii: Clinical characteristics, epidemiology and pathogenesis

Expert Review of Anti-Infective Therapy

Volumn 13, Issue 5, 2015, Pages 567-573

  Dexter, Carina ^a   Murray, Gerald L ^a   Paulsen, Ian T ^b   Peleg, Anton Y ^a,c  

^a MONASH UNIVERSITY   (Australia)

^b MACQUARIE UNIVERSITY   (Australia)

^c ALFRED HOSPITAL   (Australia)

Author keywords

A; baumannii; CA Ab; community acquired pneumonia; ethanol

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AZITHROMYCIN; BETA LACTAM; CEPHALOSPORIN DERIVATIVE; IMIPENEM; MEROPENEM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULFONAMIDE; TETRACYCLINE DERIVATIVE;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTION; ALCOHOL CONSUMPTION; ANTIBIOTIC RESISTANCE; CHRONIC LUNG DISEASE; COMMUNITY ACQUIRED ACINETOBACTER BAUMANNII; COMMUNITY ACQUIRED PNEUMONIA; DIABETES MELLITUS; DISEASE COURSE; DISEASE SEVERITY; FEVER; HUMAN; MICROBIOLOGICAL EXAMINATION; NONHUMAN; PATHOGENESIS; REVIEW; RISK FACTOR; SMOKING; ACINETOBACTER INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; DRINKING BEHAVIOR; PATHOGENICITY;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ALCOHOL DRINKING; COMMUNITY-ACQUIRED INFECTIONS; DIABETES MELLITUS; HUMANS; RISK FACTORS;

EID: 84927618494     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.2015.1025055     Document Type: Review

References (73)

1. Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev 2008;21(3):538-82
2. Anstey NM, Currie BJ, Withnall KM. Community-acquired Acinetobacter pneumonia in the Northern Territory of Australia. Clin Infect Dis 1992;14(1):83-91
3. Chen MZ, Hsueh PR, Lee LN, et al. Severe community-acquired pneumonia due to Acinetobacter baumannii. Chest J 2001; 120(4):1072-7
4. Leung WS, Chu CM, Tsang KY, et al. Fulminant community-acquired Acinetobacter baumannii pneumonia as a distinct clinical syndrome. Chest J 2006; 129(1):102-9
5. Wang JT, McDonald LC, Chang SC, et al. Community-acquired Acinetobacter baumannii bacteremia in adult patients in Taiwan. J Clin Microbiol 2002;40(4): 1526-9
6. Falagas M, Karveli E, Kelesidis I, et al. Community-acquired Acinetobacter infections. Eur J Clin Microbiol Infect Dis 2007;26(12):857-68
7. Davis JS, McMillan M, Swaminathan A, et al. A 16-year prospective study of community-onset bacteremic Acinetobacter pneumonia: low mortality with appropriate initial empirical antibiotic protocols. Chest 2014;146(4):1038-45
8. Nemec A, Krizova L, Maixnerova M, et al. Genotypic and phenotypic characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii sp. nov. (formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Acinetobacter genomic species 13TU). Res Microbiol 2011;162(4): 393-404
9. Koh T, Tan T, Khoo C, et al. Acinetobacter calcoaceticus-Acinetobacter baumannii complex species in clinical specimens in Singapore. Epidemiol Infect 2012;140(03):535-8
10. Houang ETS, Chu YW, Leung CM, et al. Epidemiology and infection control implications of Acinetobacter spp. in Hong Kong. J Clin Microbiol 2001;39(1):228-34
11. Molina J, Cisneros JM, Fernández-Cuenca F, et al. Clinical features of infections and colonization by Acinetobacter Genospecies 3. J Clin Microbiol 2010;48(12):4623-6
12. Seifert H, Dijkshoorn L, Gerner-Smidt P, et al. Distribution of Acinetobacter species on human skin: comparison of phenotypic and genotypic identification methods. J Clin Microbiol 1997;35(11):2819-25
13. Prashanth K, Ranga MPM, Rao VA, et al. Corneal perforation due to Acinetobacter junii: a case report. Diagn Microbiol Infect Dis 2000;37(3):215-17
14. Reindersma P, Nohlmans L, Korten JJ. Acinetobacter, an infrequent cause of community acquired bacterial meningitis. Clin Neurol Neurosurg 1993;95(1):71-3
15. Bilgic H, Akin E, Tąsan Y, et al. A case of Acinetobacter calcoaceticus pneumonia. Thorax 1995;50(3):315-16
16. Barnes DJ, Naraqi S, Igo JD. Community-acquired Acinetobacter pneumonia in adults in papua new Guinea. Rev Infect Dis 1988;10(3):636-9
17. de Miguel Prieto J. Community-acquired Acinetobacter pneumonia. Chest J 1980; 78(4):670a-670
18. Choi JY, Kim Y, Ko EA, et al. Acinetobacter species isolates from a range of environments: species survey and observations of antimicrobial resistance. Diagn Microbiol Infect Dis 2012;74(2): 177-80
19. Berlau J, Aucken HM, Houang E, et al. Isolation of Acinetobacter spp including A. baumannii from vegetables: implications for hospital-acquired infections. J Hosp Infect 1999;42(3):201-4
20. Ong CW, Lye DC, Khoo KL, et al. Severe community-acquired Acinetobacter baumannii pneumonia: an emerging highly lethal infectious disease in the Asia-Pacific. Respirology 2009;14(8):1200-5
21. Oh YJ, Song SH, Baik SH, et al. A case of fulminant community-acquired Acinetobacter baumannii pneumonia in Korea. Korean J Intern Med 2013;28(4): 486-90
22. Anstey NM, Currie BJ, Hassell M, et al. Community-acquired bacteremic Acinetobacter pneumonia in tropical Australia is caused by diverse strains of Acinetobacter baumannii, with carriage in the throat in at-risk groups. J Clin Microbiol 2002;40(2):685-6
23. Bick JA, Semel JD. Fulminant community-acquired Acinetobacter pneumonia in a healthy woman. Clin Infect Dis 1993;17(4):820-1
24. Westh H, Terp J. Community-acquired bacteremic Acinetobacter calcoaceticus var. anitratus pneumonia. Infection 1988;16(5): 303-4
25. Gradon JD, Chapnick EK, Lutwick LI. Infective endocarditis of a native valve due to Acinetobacter: case report and review. Clin Infect Dis 1992;14(5):1145-8
26. Cordes LG, Brink EW, Checko PJ, et al. A cluster of Acinetobacter pneumonia in foundry workers. Ann Intern Med 1981; 95(6):688-93
27. Goodhart GL, Abrutyn E, Watson R, et al. Community-acquired Acinetobacter calcoaceticus var anitratus pneumonia. JAMA 1977;238(14):1516-18
28. Christie C, Mazon D Jr, et al. Molecular heterogeneity of Acinetobacter baumanii isolates during seasonal increase in prevalence. Infect Control Hosp Epidemiol 1995;16(10):590-4
29. Chu YW, Leung CM, Houang ETS, et al. Skin Carriage of Acinetobacters in Hong Kong. J Clin Microbiol 1999;37(9):2962-7
30. Zeana C, Larson E, Sahni J, et al. The epidemiology of multidrug-resistant Acinetobacter baumannii: does the community represent a reservoir? Infect Control Hosp Epidemiol 2003;24(4):275-9
31. Dijkshoorn L, Aucken H, Gerner-Smidt P, et al. Comparison of outbreak and nonoutbreak Acinetobacter baumannii strains by genotypic and phenotypic methods. J Clin Microbiol 1996;34(6):1519-25
32. Peng C, Zong Z, Fan H. Acinetobacter baumannii isolates associated with community-acquired pneumonia in West China. Clin Microbiol Infect 2012;18(12): E491-3
33. Ozaki T, Nishimura N, Arakawa Y, et al. Community-acquired Acinetobacter baumannii meningitis in a previously healthy 14-month-old boy. J Infect Chemother 2009;15(5):322-4
34. Alcohol use and your health. Centers for Disease Control and Prevention. Atlanta G 2014. Available from: http://www.cdc.gov/alcohol/fact-sheets/alcohol-use.htm [Last accessed 26 November 2014]
35. Lowman W, Kalk T, Menezes CN, et al. A case of community-acquired Acinetobacter baumannii meningitis-has the threat moved beyond the hospital? J Med Microbiol 2008;57(5):676-8
36. Farrugia DN, Elbourne LD, Hassan KA, et al. The complete genome and phenome of a community-acquired Acinetobacter baumannii. PLoS One 2013; 8(3):e58628
37. Gamble L, Mason CM, Nelson S. The effects of alcohol on immunity and bacterial infection in the lung. Med Mal Infect 2006; 36(2):72-7
38. Pruett SB, Schwab C, Zheng Q, et al. Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3. J Immunol 2004;173(4):2715-24
39. Goral J, Karavitis J, Kovacs EJ. Exposure-dependent effects of ethanol on the innate immune system. Alcohol 2008; 42(4):237-47
40. Cook RT, Zhu X, Coleman RA, et al. T-cell activation after chronic ethanol ingestion in mice. Alcohol 2004;33(3): 175-81
41. Asplund MB, Coelho C, Cordero RJ, et al. Alcohol impairs J774. 16 macrophage-like cell antimicrobial functions in acinetobacter baumannii infection. Virulence 2013;4(6): 467-72
42. Fiuza C, Salcedo M, Clemente G, et al. In vivo neutrophil dysfunction in cirrhotic patients with advanced liver disease. J Infect Dis 2000;182(2):526-33
43. Gandhi JA, Ekhar VV, Asplund MB, et al. Alcohol enhances Acinetobacter baumannii-associated pneumonia and systemic dissemination by impairing neutrophil antimicrobial activity in a murine model of infection. PLoS One 2014;9(4): e95707
44. Crews FT, Bechara R, Brown LA, et al. Cytokines and Alcohol. Alcohol Clin Exp Res 2006;30(4):720-30
45. Nouri-Aria KT, Alexander GJ, Portmann BC, et al. T and B cell function in alcoholic liver disease. J Hepatol 1986; 2(2):195-207
46. Smith MG, Des Etages SG, Snyder M. Microbial synergy via an ethanol-triggered pathway. Mol Cell Biol 2004;24(9):3874-84
47. Smith MG, Gianoulis TA, Pukatzki S, et al. New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes Dev 2007;21(5):601-14
48. Edwards J, Patel G, Wareham DW. Low concentrations of commercial alcohol hand rubs facilitate growth of and secretion of extracellular proteins by multidrug-resistant strains of Acinetobacter baumannii. J Med Microbiol 2007;56(12):1595-9
49. Nwugo CC, Arivett BA, Zimbler DL, et al. Effect of ethanol on differential protein production and expression of potential virulence functions in the opportunistic pathogen Acinetobacter baumannii. PLoS One 2012;7(12):e51936
50. Geerlings SE, Hoepelman AI. Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol Med Microbiol 1999;26(3-4):259-65
51. Garćia-Garmendia JL, Ortiz-Leyba C, Garnacho-Montero J, et al. Risk Factors for Acinetobacter baumannii Nosocomial Bacteremia in Critically Ill Patients: a Cohort Study. Clin Infect Dis 2001; 33(7):939-46
52. Delamaire M, Maugendre D, Moreno M, et al. Impaired leucocyte functions in diabetic patients. Diabet Med 1997;14(1): 29-34
53. Andersen B, Goldsmith GH, Spagnuolo PJ. Neutrophil adhesive dysfunction in diabetes mellitus; the role of cellular and plasma factors. J Lab Clin Med 1988;111(3):275-85
54. Tater D, Tepaut B, Bercovici JP, et al. Polymorphonuclear cell derangements in type I diabetes. Horm Metab Res 1987; 19(12):642-7
55. Balasoiu D, van Kessel KC, van Kats-Renaud HJ, et al. Granulocyte function in women with diabetes and asymptomatic bacteriuria. Diabetes Care 1997;20(3):392-5
56. Repine JE, Clawson CC, Goetz FC. Bactericidal function of neutrophils from patients with acute bacterial infections and from diabetics. J Infect Dis 1980;142(6): 869-75
57. Mazade MA, Edwards MS. Impairment of type III Group B streptococcus-stimulated superoxide production and opsonophagocytosis by neutrophils in diabetes. Mol Genet Metab 2001;73(3): 259-67
58. Lecube A, Pachon G, Petriz J, et al. Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement. PLoS One 2011;6(8):e23366
59. Peleg AY, Weerarathna T, McCarthy JS, et al. Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev 2007;23(1):3-13
60. Zozulinska D, Majchrzak A, Sobieska M, et al. Serum interleukin-8 level is increased in diabetic patients. Diabetologia 1999; 42(1):117-18
61. Ohno Y, Aoki N, Nishimura A. In vitro production of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1993;77(4):1072-7
62. Fournier PE, Vallenet D, Barbe V, et al. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet 2006;2(1):e7
63. Lee Y, Yoon S, Lee HS, et al. A case of severe community-acquired Acinetobacter baumannii pneumonia with bacteremia. Infect Chemother 2012;44(2):71-4
64. Sharma A, Shariff M, Thukral SS, et al. Chronic community-acquired Acinetobacter pneumonia that responded slowly to rifampicin in the anti-tuberculous regime. J Infect 2005;51(3):e149-52
65. Suchyta MR, Peters JI, Black RD. Chronic Acinetobacter calcoaceticus var antiratus pneumonia. Am J Med Sci 1987;294(2): 117-19
66. Carter JD, Cutolo EP, Behnke RH, et al. Pulmonary infiltrates in an elderly man. Hosp Pract (1995) 1999;34(8):21-2
67. Chang WN, Lu CH, Huang CR, et al. Community-Acquired Acinetobacter Meningitis in Adults. Infection 2000;28(6): 395-7
68. Lu CH, Huang CR, Chang WN, et al. Community-acquired bacterial meningitis in adults: the epidemiology, timing of appropriate antimicrobial therapy, and prognostic factors. Clin Neurol Neurosurg 2002;104(4):352-8
69. Ryu SH, Yu CM, Suh SO, et al. A case of community-acquired Acinetobacter meningitis. Infect Chemother 2012;44(6):473-6
70. Chiang WC, Su CP, Hsu CY, et al. Community-acquired bacteremic cellulitis caused by Acinetobacter baumannii. J Formos Med Assoc 2003;102(9):650-2
71. Astal Z, El-Manama A, Sharif F. Antibiotic resistance of bacteria associated with community-acquired urinary tract infections in the southern area of the Gaza Strip. J Chemother 2002;14(3):259-64
72. Lau SM, Peng MY, Chang FY. Resistance rates to commonly used antimicrobials among pathogens of both bacteremic and non-bacteremic community-acquired urinary tract infection. J Microbiol Immunol Infect 2004;37(3):185-91
73. Antibiotic Expert Groups. Therapeutic guidelines: antibiotic. Version 15. Melbourne: Therapeutic Guidelines Limited; 2014