-
1
-
-
69549124775
-
Targeting interleukin-6 in pediatric rheumatic diseases
-
De Benedetti F. Targeting interleukin-6 in pediatric rheumatic diseases. Curr Opin Rheumatol 2009, 21:533-537.
-
(2009)
Curr Opin Rheumatol
, vol.21
, pp. 533-537
-
-
De Benedetti, F.1
-
2
-
-
84871318830
-
Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis
-
De Benedetti F., Brunner H.I., Ruperto N., et al. Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis. N Engl J Med 2012, 367:2385-2395.
-
(2012)
N Engl J Med
, vol.367
, pp. 2385-2395
-
-
De Benedetti, F.1
Brunner, H.I.2
Ruperto, N.3
-
3
-
-
40749152243
-
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial
-
Yokota S., Imagawa T., Mori M., et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet 2008, 371:998-1006.
-
(2008)
Lancet
, vol.371
, pp. 998-1006
-
-
Yokota, S.1
Imagawa, T.2
Mori, M.3
-
4
-
-
84874417699
-
Long-term treatment of systemic juvenile idiopathic arthritis with tocilizumab: results of an open label extension study in Japan
-
Yokota S., Imagawa T., Mori M., et al. Long-term treatment of systemic juvenile idiopathic arthritis with tocilizumab: results of an open label extension study in Japan. Ann Rheum Dis 2013, 72:627-628.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 627-628
-
-
Yokota, S.1
Imagawa, T.2
Mori, M.3
-
5
-
-
84864881812
-
Sustained remission of multicentric Castleman disease in children treated with tocilizumab, an anti-interleukin-6-receptor antibody
-
Galeotti C., Boucheron A., Guillaume S., et al. Sustained remission of multicentric Castleman disease in children treated with tocilizumab, an anti-interleukin-6-receptor antibody. Mol Cancer Ther 2012, 11:1623-1626.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 1623-1626
-
-
Galeotti, C.1
Boucheron, A.2
Guillaume, S.3
-
6
-
-
40749114497
-
Effect of interleukin-6-receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
-
Smolen J.S., Beaulieu A., Rubbert-Roth A., et al. Effect of interleukin-6-receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 2008, 371:987-997.
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
-
7
-
-
27144488346
-
Humanized anti-interleukin-6-receptor antibody treatment of multicentric Castleman disease
-
Nishimoto N., Kanakura Y., Aozasa K., et al. Humanized anti-interleukin-6-receptor antibody treatment of multicentric Castleman disease. Blood 2005, 106:2627-2632.
-
(2005)
Blood
, vol.106
, pp. 2627-2632
-
-
Nishimoto, N.1
Kanakura, Y.2
Aozasa, K.3
-
8
-
-
31544451391
-
Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6-receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement
-
Woo P., Wilkinson N., Prieur A.M., et al. Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6-receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement. Arthritis Res Ther 2005, 7:R1281-R1288.
-
(2005)
Arthritis Res Ther
, vol.7
, pp. R1281-R1288
-
-
Woo, P.1
Wilkinson, N.2
Prieur, A.M.3
-
9
-
-
20144362101
-
Therapeutic efficacy of humanized recombinant anti-interleukin-6-receptor antibody in children with systemic-onset juvenile idiopathic arthritis
-
Yokota S., Miyamae T., Imagawa T., et al. Therapeutic efficacy of humanized recombinant anti-interleukin-6-receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 2005, 52:818-825.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 818-825
-
-
Yokota, S.1
Miyamae, T.2
Imagawa, T.3
-
10
-
-
84874207708
-
Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis
-
Yokota S., Tanaka T., Kishimoto T. Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis. Ther Adv Musculoskelet Dis 2012, 4:387-397.
-
(2012)
Ther Adv Musculoskelet Dis
, vol.4
, pp. 387-397
-
-
Yokota, S.1
Tanaka, T.2
Kishimoto, T.3
-
11
-
-
84859210566
-
Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: the diagnostic significance of interleukin-18 and interleukin-6
-
Shimizu M., Nakagishi Y., Kasai K., et al. Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: the diagnostic significance of interleukin-18 and interleukin-6. Cytokine 2012, 58:287-294.
-
(2012)
Cytokine
, vol.58
, pp. 287-294
-
-
Shimizu, M.1
Nakagishi, Y.2
Kasai, K.3
-
13
-
-
84865441040
-
Risk of significant cytopenias after treatment with tocilizumab in systemic juvenile arthritis patients with a history of macrophage activation syndrome
-
Kessler E.A., Vora S.S., Verbsky J.W. Risk of significant cytopenias after treatment with tocilizumab in systemic juvenile arthritis patients with a history of macrophage activation syndrome. Pediatr Rheumatol Online J 2012, 10:30.
-
(2012)
Pediatr Rheumatol Online J
, vol.10
, pp. 30
-
-
Kessler, E.A.1
Vora, S.S.2
Verbsky, J.W.3
-
14
-
-
84861479447
-
Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis
-
Imagawa T., Yokota S., Mori M., et al. Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis. Mod Rheumatol 2012, 22:109-115.
-
(2012)
Mod Rheumatol
, vol.22
, pp. 109-115
-
-
Imagawa, T.1
Yokota, S.2
Mori, M.3
-
15
-
-
84878541159
-
Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases
-
Alten R., Maleitzke T. Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases. Ann Med 2013, 45:357-363.
-
(2013)
Ann Med
, vol.45
, pp. 357-363
-
-
Alten, R.1
Maleitzke, T.2
|