Metformin treatment in type 2 diabetes in pregnancy: An active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy

Journal of Diabetes Research

Volumn 2015, Issue , 2015, Pages

  Ainuddin, Jahan Ara ^a   Karim, Nasim ^b   Zaheer, Sidra ^a   Ali, Syed Sanwer ^c   Hasan, Anjum Ara ^d  

^a DOW UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

^b BAHRIA UNIVERSITY   (Pakistan)

^c United Medical and Dental College   (Pakistan)

^d HAMDARD UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPHANE INSULIN; METFORMIN; RECOMBINANT HUMAN INSULIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; INSULIN;

ADD ON THERAPY; ADULT; ARTICLE; CONTROLLED STUDY; COST CONTROL; DRUG COST; DRUG DOSE INCREASE; FEMALE; GESTATIONAL AGE; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INSULIN TREATMENT; LENGTH OF STAY; LOADING DRUG DOSE; MATERNAL HYPERTENSION; NEWBORN INTENSIVE CARE; NON INSULIN DEPENDENT DIABETES MELLITUS; OPEN STUDY; PARALLEL DESIGN; PHASE 3 CLINICAL TRIAL; PREECLAMPSIA; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMALL FOR DATE INFANT; TREATMENT OUTCOME; VAGINAL DELIVERY; WEIGHT GAIN; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; PREGNANCY; PREGNANCY COMPLICATIONS;

ADULT; BLOOD GLUCOSE; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; GESTATIONAL AGE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; METFORMIN; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 84927539175     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2015/325851     Document Type: Article

References (28)

1. C. W. Spellman, "Pathophysiology of type 2 diabetes: Targeting islet cell dysfunction, " The Journal of the American Osteopathic Association, vol. 110, no. 3, pp. S2-S7, 2010.
2. C. A. Crawther, J. E. Hiller, R. J. Moss et al., "Effect of treatment of gestational diabetes mellitus on pregnancy outcomes, " The New England Journal of Medicine, vol. 352, no. 24, pp. 2477- 2486, 2005.
3. S. E. Inzucchi, R.M.Bergenstal, J. B. Buse et al., "Managementof hyperglycaemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the study of diabetes (EASD), " Diabetologia, vol. 55, no. 6, pp. 1577-1597, 2012.
4. G. Hawthorne, "Metformin use and diabetic pregnancy-has its time come?" DiabeticMedicine, vol. 23, no. 3, pp. 223-227, 2006.
5. A. E. Caballero, A. Delgado, C. A. Aguilar-Salinas et al., "The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: A placebo-controlled, randomized clinical trial, " Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 8, pp. 3943-3948, 2004.
6. D. Kirpichikov, S. I. McFarlane, and J. R. Sowers, "Metformin: An update, " Annals of Internal Medicine, vol. 63, pp. 1879-1894, 2002.
7. J. A. Rowan, W. M. Hague, W. Gao, M. R. Battin, and M. P. Moore, "Metformin versus insulin for the treatment of gestational diabetes, "The New England Journal of Medicine, vol. 358, no. 19, pp. 2003-2015, 2008.
8. W. M. Hague, P. M. Davoren, D. McIntyre, R. Norris, X. Xiaonian, and B. G. Charles, "Metformin crosses the placenta, " in Proceedings of the Medicine and Pregnancy, Novo Nordisk, Fremantle, Australia, October 2003.
9. C. J. Glueck, N.Goldenberg, J. Pranicoff, M. Loftspring, L. Sieve, and P. Wang, "Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy, " Human Reproduction, vol. 19, no. 6, pp. 1323-1330, 2004.
10. L. Harborne, R. Fleming, H. Lyall, J. Norman, and N. Sattar, "Descriptive review of the evidence for the use of metformin in polycystic ovary syndrome, " The Lancet, vol. 361, no. 9372, pp. 1894-1901, 2003.
11. S. Waheed, F. P. Malik, and S. B. Mazhar, "Efficacy of metformin versus insulin in the management of pregnancy with diabetes, " Journal of the College of Physicians and Surgeons Pakistan, vol. 23, no. 12, pp. 866-869, 2013.
12. R. C. E. Hughes and J. A. Rowan, "Pregnancy in women with type 2 diabetes:who takes metformin andwhat is the outcome?" Diabetic Medicine, vol. 23, no. 3, pp. 318-322, 2006.
13. C.O. Ekpebegh, E. J.Coetzee, L. van der Merwe, and N. S. Levitt, "A 10-year retrospective analysis of pregnancy outcome in pregestational Type 2 diabetes: comparison of insulin and oral glucose-lowering agents, " Diabetic Medicine, vol. 24, no. 3, pp. 253-258, 2007.
14. M. A. Mohammed, A. M. Abdelmonem, M. A. Abdullah, and A. A. El-Sayed, "Oral hypoglycemic as attractive alternative to insulin for the management of diabetes mellitus during pregnancy, " Gynecology & Obstetrics, vol. 4, no. 1, article 193, 2014.
15. J. Balani, S. L. Hyer, D. A. Rodin, and H. Shehata, "Pregnancy outcomes in women with gestational diabetes treated withmetformin or insulin: A case-control study, " Diabetic Medicine, vol. 26, no. 8, pp. 798-802, 2009.
16. C. P. Spaulonci, L. S. Bernardes, T. C. Trindade, M. Zugaib, and R. P. V. Francisco, "Randomized trial ofmetformin vs insulin in the management of gestational diabetes, " American Journal of Obstetrics and Gynecology, vol. 209, no. 1, pp. 34.e1-34.e7, 2013.
17. L. Rai, D. Meenakshi, and A. Kamath, "Metformin-a convenient alternative to insulin for Indian women with diabetes in pregnancy, " Indian Journal ofMedical Sciences, vol. 63, no. 11, pp. 491-497, 2009.
18. M. A. Hickman, R. McBride, K. A. Boggess, and R. Strauss, "Metformin compared with insulin in the treatment of pregnant women with overt diabetes: A randomized controlled trial, " The American Journal of Perinatology, vol. 30, no. 6, pp. 483-489, 2013.
19. K. Tertti, U. Ekblad, T. Vahlberg, and T. Rönnemaa, "Comparison of metformin and insulin in the treatment of gestational diabetes: A retrospective, case-control study, " Review of Diabetic Studies, vol. 5, no. 2, pp. 95-101, 2008.
20. M. I. Ibrahim, A. Hamdy, A. Shafik, S. Taha, M. Anwar, and M. Faris, "The role of addingmetformin in insulin-resistant diabetic pregnant women: A randomized controlled trial, " Archives of Gynecology and Obstetrics, vol. 289, no. 5, pp. 959-965, 2014.
21. B. Viollet, B. Guigas, N. S. Garcia, J. Leclerc, M. Foretz, and F. Andreelli, "Cellular and molecular mechanisms of metformin: An overview, " Clinical Science, vol. 122, no. 6, pp. 253-270, 2012.
22. K. Swaminathan, H. C. S. Howlett, and I. W. Campbell, "Metformin in diabetic pregnancy, " Journal of the Royal College of Physicians of Edinburgh, vol. 39, no. 1, pp. 10-14, 2009.
23. H. Ijas, M. Vaarasmaki, and L. Morinpaunen, "Metfromin should be considered in the treatment of gestational diabetes: A prospective randomized study, " BJOG, vol. 10, 2010.
24. E. Hellmuth, P. Damm, and L. Mølsted-Pedersen, "Oral hypoglycaemic agents in 118 diabetic pregnancies, " Diabetic Medicine, vol. 17, no. 7, pp. 507-511, 2000.
25. L. E.Moore, G. I. Brieny, and D.Clokey, "Metformin and insulin in themanagement of gestational diabetes mellitus, " The Journal of Reproductive Medicine, vol. 52, pp. 1011-1015, 2007.
26. E. J. Coetzee and W. P. U. Jackson, "Pregnancy in established non-insulin-dependent diabetics. A five-and-a-half year study at Groote Schuur Hospital, " South African Medical Journal, vol. 58, no. 20, pp. 795-802, 1980.
27. Clinical Guidelines Task Force and International Diabetes Federation, Global Guidelines for Type 2 Diabetes, 2009, http://www.idf.org/.
28. J. Ainuddin, N. Karim, A. A. Hasan, and S. A. Naqvi, "Metformin versus insulin treatment in gestational diabetes in pregnancy in a developing country. A randomized control trial, " Diabetes Research and Clinical Practice, vol. 107, no. 2, pp. 290- 299, 2015.