Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy

Journal of Physiology and Pharmacology

Volumn 66, Issue 2, 2015, Pages 227-231

  Tomaszek, A ^a,b   Kiczak, Liliana ^a,c   Bania, J ^a,c   Paslawska, U ^a,c   Zacharski, M ^a,c   Janiszewski, A ^a,c   Noszczyk Nowak, A ^a,c   Dziegiel, P ^a,b   Kuropka, P ^c   Ponikowski, P ^a,b   Jankowska, E A ^a,b  

^a REGIONAL SPECIALIST HOSPITAL   (Poland)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

^c WROC AW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

Adrenal glands; Cardiomyopathy; Circulating catecholamines; Dopamine hydroxylase; Tachyarrhythmic experimental model of heart failure; Tyrosine hydroxylase

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; BRAIN NATRIURETIC PEPTIDE; CATECHOLAMINE; CATECHOLAMINE SYNTHESIZING ENZYME; DOPAMINE BETA MONOOXYGENASE; ENZYME; PHENYLETHANOLAMINE N METHYLTRANSFERASE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; ADRENALIN; MESSENGER RNA; NORADRENALIN;

ADRENAL GLAND; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE EXPRESSION; HEART LEFT VENTRICLE EJECTION FRACTION; HISTOLOGY; MALE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; SWINE; TACHYCARDIA INDUCED CARDIOMYOPATHY; ANIMAL; BLOOD; CARDIOMYOPATHY; ENZYMOLOGY; GENETICS; HEART VENTRICLE; METABOLISM; PATHOPHYSIOLOGY; PIG; TACHYCARDIA;

ADRENAL GLANDS; ANIMALS; AROMATIC-L-AMINO-ACID DECARBOXYLASES; CARDIOMYOPATHIES; CATECHOLAMINES; DOPAMINE BETA-HYDROXYLASE; EPINEPHRINE; GENE EXPRESSION; HEART VENTRICLES; MALE; NATRIURETIC PEPTIDE, BRAIN; NOREPINEPHRINE; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RNA, MESSENGER; SWINE; TACHYCARDIA; TYROSINE 3-MONOOXYGENASE;

EID: 84927521546     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Chatterjee K. Pathophysiology of systolic and diastolic heart failure. Med Clin North Am 2012; 96: 891-899.
2. Jankowska EA, Ponikowski P, Piepoli MF, Banasiak W, Anker SD, Poole-Wilson PA. Autonomic imbalance and immune activation in chronic heart failure - pathophysiological links. Cardiovasc Res 2006; 70: 434-445.
3. Cohn JN, Levine TB, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984; 311: 819-823.
4. Hasking GJ, Esler MD, Jennings GL, Burton D, Johns JA, Korner PI. Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 1986; 73: 615-621.
5. Dixon JA, Spinale FG. Large animal models of heart failure: A critical link in the translation of basic science to clinical practice. Circ Heart Fail 2009; 2: 262-271.
6. Leenen FH. Brain mechanisms contributing to sympathetic hyperactivity and heart failure. Circ Res 2007; 101: 221-223.
7. Kvetnansky R, Sabban EL, Palkovits M. Catecholaminergic systems in stress: structural and molecular genetics approaches. Physiol Rev 2009; 89: 535-606.
8. Kvetnansky R, Weise VK, Thoa NB, Kopin IJ. Effects of chronic guanethidine treatment and adrenal medullectomy on plasma levels of catecholamines and corticosterone in forcibly immobilized rats. J Pharmacol Exp Ther 1979; 209: 287-291.
9. Kiczak L, Tomaszek A, Bania J, et al. Expression and complex formation of MMP9, MMP2, NGAL and TIMP1 in porcine myocardium but not in skeletal muscles in male pigs with systolic heart failure. Biomed Res Int 2013; 2013: 283856. doi: 10.1155/2013/283856.
10. Kiczak L, Tomaszek A, Bania J, et al. Matrix metalloproteinase 9/neutrophil gelatinase associated lipocalin/tissue inhibitor of metalloproteinasess type 1 complexes are localized within cardiomyocytes and serve as a reservoir of active metalloproteinase in porcine female myocardium. J Physiol Pharmacol. 2014; 65: 365-375.
11. Tomaszek A, Kiczak L, Bania J, et al. Changes in parasympathetic system in medulla oblongata in male pigs in the course of tachycardia-induced cardiomyopathy. Auton Neurosci 2013; 177: 253-259.
12. Khan MB, Lee BR, Kamitani T. A simple and sensitive method for the demonstration of norepinephrine-storing adrenomedullary chromaffin cells. Histochem Cell Biol 2012; 138: 155-165.
13. Pfaffl MW. A new mathematical model for quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: 2000-2007.
14. Malpas SC. Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. Physiol Rev 2010; 90: 513-557.
15. Aunis D, Langley K. Physiological aspects of exocytosis in chromaffin cells of the adrenal medulla. Acta Physiol Scand 1999; 167: 89-97.
16. Verhofstad AA, Coupland RE, Colenbrander B. Immunohistochemical and biochemical analysis of the development of the noradrenaline- and adrenaline-storing cells in the adrenal medulla of the rat and pig. Arch Histol Cytol 1989; 52 (Suppl): 351-360.
17. Schneider J, Lother A, Hein L, Gilsbach R. Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis. Basic Res Cardiol 2011; 106: 591-602.
18. Kaminska B, Czerwinska J, Wojciechowicz B, Nynca A, Ciereszko R. Genistein and daidzein affect in vitro steroidogenesis but not gene expression of steroidogenic enzymes in adrenals of pigs. J Physiol Pharmacol 2014; 65: 127-133.
19. Bakovic D, Pivac N, Zubin Maslov P, Breskovic T, Damonja G, Dujic Z. Spleen volume changes during adrenergic stimulation with low doses of epinephrine. J Physiol Pharmacol. 2013; 64: 649-655.
20. Sabban EL, Nankova BB, Serova LI, Kvetnansky R, Liu X. Molecular regulation of gene expression of catecholamine biosynthetic enzymes by stress: sympathetic ganglia versus adrenal medulla. Ann NY Acad Sci 2004; 1018: 370-377.