Drugs of Abuse in HIV infection and neurotoxicity

Frontiers in Microbiology

Volumn 6, Issue MAR, 2015, Pages

  Hidalgo, Melissa ^a   Atluri, Venkata S R ^a   Nair, Madhavan ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

Alcohol; Cannabinoids; Cocaine; HIV; Methamphetamine; Neurocognitive disorders; Nicotine; Opioids

Indexed keywords

ALCOHOL; CANNABINOID; CANNABIS; CASPASE 3; CD209 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CLAUDIN 3; COCAINE; CYTOCHROME P450 2E1; GELATINASE A; GLUTAMIC ACID; GLYCOPROTEIN GP 120; HISTONE DEACETYLASE 2; ININDEXED DRUG; INTERLEUKIN 6; JUNCTIONAL ADHESION MOLECULE B; METHAMPHETAMINE; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINE; OCCLUDIN; OPIATE; PROTEIN ZO1; PROTEIN ZO2; PSYCHOSTIMULANT AGENT; QUINOLINIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WNT5A PROTEIN; WNT7A PROTEIN;

ARTICLE; DRUG ABUSE; ENCEPHALITIS; GENE EXPRESSION; GENETIC VARIABILITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NEUROTOXICITY; TOBACCO;

EID: 84927517668     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00217     Document Type: Article

References (56)

1. Antinori, A., Trotta, M. P., Lorenzini, P., Torti, C., Gianotti, N., Maggiolo, F., et al. (2007). Virological response to salvage therapy in HIV-infected persons carrying the reverse transcriptase K65R mutation. Antivir. Ther. 12, 1175-1183.
2. Atluri, V. S., Kanthikeel, S. P., Reddy, P. V., Yndart, A., and Nair, M. P. (2013). Human synaptic plasticity gene expression profile and dendritic spine density changes in HIV-infected human CNS cells: role in HIV-associated neurocognitive disorders (HAND). PLoS ONE 8:e61399. doi: 10.1371/journal.pone.0061399.
3. Atluri, V. S., Pilakka-Kanthikeel, S., Samikkannu, T., Sagar, V., Kurapati, K. R., Saxena, S. K., et al. (2014). Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder. Mol. Brain 7:37. doi: 10.1186/1756-6606-7-37.
4. Avraham, H. K., Jiang, S., Fu, Y., Rockenstein, E., Makriyannis, A., Zvonok, A., et al. (2014). The cannabinoid CB2 receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis. Br. J. Pharmacol. 171, 468-479. doi: 10.1111/bph.12478.
5. Banerjee, A., Strazza, M., Wigdahl, B., Pirrone, V., Meucci, O., and Nonnemacher, M. R. (2011). Role of mu-opioids as cofactors in human immunodeficiency virus type 1 disease progression and neuropathogenesis. J. Neurovirol. 17, 291-302. doi: 10.1007/s13365-011-0037-2.
6. Banerjee, A., Zhang, X., Manda, K. R., Banks, W. A., and Ercal, N. (2010). HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide. Free Radic. Biol. Med. 48, 1388-1398. doi: 10.1016/j.freeradbiomed.2010.02.023.
7. Berman, S., O'Neill, J., Fears, S., Bartzokis, G., and London, E. D. (2008). Abuse of amphetamines and structural abnormalities in the brain. Ann. N.Y. Acad. Sci. 1141, 195-220. doi: 10.1196/annals.1441.031.
8. Beyrer, C., Wirtz, A. L., Baral, S., Peryskina, A., and Sifakis, F. (2010). Epidemiologic links between drug use and HIV epidemics: an international perspective. J. Acquir. Immune Defic. Syndr. 55(Suppl. 1), S10-S16. doi: 10.1097/QAI.0b013e3181f9c0c9.
9. Brandt, J., Butters, N., Ryan, C., and Bayog, R. (1983). Cognitive loss and recovery in long-term alcohol abusers. Arch. Gen. Psychiatry 40, 435-442. doi: 10.1001/archpsyc.1983.01790040089012.
10. Buch, S., Yao, H., Guo, M., Mori, T., Su, T.-P., and Wang, J. (2012). Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction. J. Neuroimmune Pharmacol. 6, 503-515. doi: 10.1007/s11481-011-9297-0.
11. Byrd, D. A., Fellows, R. P., Morgello, S., Franklin, D., Heaton, R. K., Deutsch, R., et al. (2011). Neurocognitive impact of substance use in HIV infection. J. Acquir. Immune Defic. Syndr. 58, 154-162. doi: 10.1097/QAI.0b013e318229ba41.
12. Cao, J., Wang, S., Wang, J., Cui, W., Nesil, T., Vigorito, M., et al. (2013). RNA deep sequencing analysis reveals that nicotine restores impaired gene expression by viral proteins in the brains of HIV-1 transgenic rats. PLoS ONE 8:e68517. doi: 10.1371/journal.pone.0068517.
13. Conant, K., St Hillaire, C., Anderson, C., Galey, D., Wang, J., and Nath, A. (2004). Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases. J. Neurovirol. 10, 21-28. doi: 10.1080/13550280490261699.
14. Cook, J. A., Grey, D. D., Burke-Miller, J. K., Cohen, M. H., Vlahov, D., Kapadia, F., et al. (2007). Illicit drug use, depression and their association with highly active antiretroviral therapy in HIV-positive women. Drug Alcohol Depend. 89, 74-81. doi: 10.1016/j.drugalcdep.2006.12.002.
15. Cristiani, S. A., Pukay-Martin, N. D., and Bornstein, R. A. (2004). Marijuana use and cognitive function in HIV-infected people. J. Neuropsychiatry Clin. Neurosci. 16, 330-335. doi: 10.1176/jnp.16.3.330.
16. Czub, S., Koutsilieri, E., Sopper, S., Czub, M., Stahl-Hennig, C., Muller, J. G., et al. (2001). Enhancement of central nervous system pathology in early simian immunodeficiency virus infection by dopaminergic drugs. Acta Neuropathol. 101, 85-91. doi: 10.1007/s004010000313.
17. Darke, S., Sims, J., McDonald, S., and Wickes, W. (2000). Cognitive impairment among methadone maintenance patients. Addiction 95, 687-695. doi: 10.1046/j.1360-0443.2000.9556874.x.
18. Dhillon, N. K., Williams, R., Peng, F., Tsai, Y. J., Dhillon, S., Nicolay, B., et al. (2007). Cocaine-mediated enhancement of virus replication in macrophages: implications for human immunodeficiency virus-associated dementia. J. Neurovirol. 13, 483-495. doi: 10.1080/13550280701528684.
19. Dutta, R., and Roy, S. (2012). Mechanism(s) involved in Opioid drug abuse modulation of HAND. Curr. HIV Res. 10, 469-477. doi: 10.2174/157016212802138805.
20. Ellis, R., Langford, D., and Masliah, E. (2007). HIV and antiretroviral therapy in the brain: neuronal injury and repair. Nat. Rev. Neurosci. 8, 33-44. doi: 10.1038/nrn2040.
21. Eugenin, E. A., Clements, J. E., Zink, M. C., and Berman, J. W. (2011). HIV infection of human astrocytes disrupts blood brain barrier integrity by a gap junction dependent mechanism. J. Neurosci. 31, 9456-9465. doi: 10.1523/JNEUROSCI.1460-11.2011.
22. Fiala, M., Eshleman, A. J., Cashman, J., Lin, J., Lossinsky, A. S., Suarez, V., et al. (2005). Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells. J. Neurovirol. 11, 281-291. doi: 10.1080/13550280590952835.
23. Fitting, S., Knapp, P. E., Zou, S., Marks, W. D., Bowers, M. S., Akbarali, H. I., et al. (2014). Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na(+) influx, mitochondrial instability, and Ca(2)(+) overload. J. Neurosci. 34, 12850-12864. doi: 10.1523/JNEUROSCI.5351-13.2014.
24. Fitting, S., Xu, R., Bull, C., Buch, S. K., El-Hage, N., Nath, A., et al. (2011). Interactive comorbidity between opioid drug abuse and HIV-1 Tat. Am. J. Pathol. 177, 1397-1410. doi: 10.2353/ajpath.2010.090945.
25. Gelman, B. B., Lisinicchia, J. G., Chen, T., Johnson, K. M., Jennings, K., Freeman, D. H. Jr., et al. (2012). Prefrontal dopaminergic and enkephalinergic synaptic accommodation in HIV-associated neurocognitive disorders and encephalitis. J. Neuroimmune Pharmacol. 7, 686-700. doi: 10.1007/s11481-012-9345-4.
26. Gonzalez-Scarano, F., and Martin-Garcia, J. (2005). The neuropathogenesis of AIDS. Nat. Rev. Immunol. 5, 69-81. doi: 10.1038/nri1527.
27. Green, J. E., Saveanu, R. V., and Bornstein, R. A. (2004). The effect of previous alcohol abuse on cognitive function in HIV infection. Am. J. Psychiatry 161, 249-254. doi: 10.1176/appi.ajp.161.2.249.
28. Guan, J. S., Haggarty, S. J., Giacometti, E., Dannenberg, J. H., Joseph, N., Gao, J., et al. (2009). HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459, 55-60. doi: 10.1038/nature07925.
29. Hauser, K. F., and Knapp, P. E. (2014). Interactions of HIV and drugs of abuse: the importance of glia, neural progenitors, and host genetic factors. Int. Rev. Neurobiol. 118, 231-313. doi: 10.1016/B978-0-12-801284-0.00009-9.
30. Iudicello, J. E., Woods, S. P., Vigil, O., Scott, J. C., Cherner, M., Heaton, R. K., et al. (2010). Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence. J. Clin. Exp. Neuropsychol. 32, 704-718. doi: 10.1080/13803390903512637.
31. Kaul, M., Zheng, J., Okamoto, S., Gendelman, H. E., and Lipton, S. A. (2005). HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ. 12(Suppl. 1), 878-892. doi: 10.1038/sj.cdd.4401623.
32. Kim, H. J., Shin, A. H., and Thayer, S. A. (2011). Activation of cannabinoid type 2 receptors inhibits HIV-1 envelope glycoprotein gp120-induced synapse loss. Mol. Pharmacol. 80, 357-366. doi: 10.1124/mol.111.071647.
33. Korthuis, P. T., Zephyrin, L. C., Fleishman, J. A., Saha, S., Josephs, J. S., McGrath, M. M., et al. (2008). Health-related quality of life in HIV-infected patients: the role of substance use. AIDS Patient Care STDS 22, 859-867. doi: 10.1089/apc.2008.0005.
34. Kuo, W. H., Wilson, T. E., Weber, K. M., Madhava, V., Richardson, J., Delapenha, R., et al. (2004). Initiation of regular marijuana use among a cohort of women infected with or at risk for HIV in the Women's Interagency HIV Study (WIHS). AIDS Patient Care STDS 18, 702-713. doi: 10.1089/apc.2004.18.702.
35. Li, W., Huang, Y., Reid, R., Steiner, J., Malpica-Llanos, T., Darden, T. A., et al. (2008). NMDA receptor activation by HIV-Tat protein is clade dependent. J. Neurosci. 28, 12190-12198. doi: 10.1523/JNEUROSCI.3019-08.2008.
36. Liao, D., Lin, H., Law, P. Y., and Loh, H. H. (2005). Mu-opioid receptors modulate the stability of dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 102, 1725-1730. doi: 10.1073/pnas.0406797102.
37. Liu, X., Silverstein, P. S., Singh, V., Shah, A., Qureshi, N., and Kumar, A. (2012). Methamphetamine increases LPS-mediated expression of IL-8, TNF-α and IL-1Î2 in human macrophages through common signaling pathways. PLoS ONE 7:e33822. doi: 10.1371/journal.pone.0033822.
38. Mahajan, S. D., Aalinkeel, R., Sykes, D. E., Reynolds, J. L., Bindukumar, B., Adal, A., et al. (2008). Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: implication for HIV-1 neuropathogenesis in the context of drug abuse. Brain Res. 1203, 133-148. doi: 10.1016/j.brainres.2008.01.093.
39. Martin-Thormeyer, E. M., and Paul, R. H. (2009). Drug abuse and hepatitis C infection as comorbid features of HIV associated neurocognitive disorder: neurocognitive and neuroimaging features. Neuropsychol. Rev. 19, 215-231. doi: 10.1007/s11065-009-9101-6.
40. McArthur, J. C. (2004). HIV dementia: an evolving disease. J. Neuroimmunol. 157, 3-10. doi: 10.1016/j.jneuroim.2004.08.042.
41. McArthur, J. C., and Brew, B. J. (2010). HIV-associated neurocognitive disorders: is there a hidden epidemic? AIDS 24, 1367-1370. doi: 10.1097/QAD.0b013e3283391d56.
42. McCann, U. D., Wong, D. F., Yokoi, F., Villemagne, V., Dannals, R. F., and Ricaurte, G. A. (1998). Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35, 428. J. Neurosci. 18, 8417-8422.
43. Meade, C. S., Conn, N. A., Skalski, L. M., and Safren, S. A. (2011). Neurocognitive impairment and medication adherence in HIV patients with and without cocaine dependence. J. Behav. Med. 34, 128-138. doi: 10.1007/s10865-010-9293-5.
44. Miro, J. M., Del Rio, A., and Mestres, C. A. (2003). Infective endocarditis and cardiac surgery in intravenous drug abusers and HIV-1 infected patients. Cardiol. Clin. 21, 167-184, v-vi. doi: 10.1016/S0733-8651(03)00025-0.
45. Nair, M. P., Saiyed, Z. M., Nair, N., Gandhi, N. H., Rodriguez, J. W., Boukli, N., et al. (2009). Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells. J. Neuroimmune Pharmacol. 4, 129-139. doi: 10.1007/s11481-008-9128-0.
46. Nair, M. P., Schwartz, S. A., Mahajan, S. D., Tsiao, C., Chawda, R. P., Whitney, R., et al. (2004). Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDO. J. Neuroimmunol. 157, 56-60. doi: 10.1016/j.jneuroim.2004.08.040.
47. Nath, A., Hauser, K. F., Wojna, V., Booze, R. M., Maragos, W., Prendergast, M., et al. (2002). Molecular basis for interactions of HIV and drugs of abuse. J. Acquir. Immune Defic. Syndr. 31(Suppl. 2), S62-S69. doi: 10.1097/00126334-200210012-00006.
48. Nave, K. A., and Trapp, B. D. (2008). Axon-glial signaling and the glial support of axon function. Annu. Rev. Neurosci. 31, 535-561. doi: 10.1146/annurev.neuro.30.051606.094309.
49. Osmanov, S., Pattou, C., Walker, N., Schwardlander, B., and Esparza, J. (2002). Estimated global distribution and regional spread of HIV-1 genetic subtypes in the year 2000. J. Acquir. Immune Defic. Syndr. 29, 184-190. doi: 10.1097/00042560-200202010-00013.
50. Perry, S. W., Norman, J. P., Litzburg, A., Zhang, D., Dewhurst, S., and Gelbard, H. A. (2005). HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. J. Immunol. 174, 4333-4344. doi: 10.4049/jimmunol.174.7.4333.
51. Sacktor, N. (2002). The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J. Neurovirol. 8(Suppl. 2), 115-121. doi: 10.1080/13550280290101094.
52. Sacktor, N., Tarwater, P. M., Skolasky, R. L., McArthur, J. C., Selnes, O. A., Becker, J., et al. (2001). CSF antiretroviral drug penetrance and the treatment of HIV-associated psychomotor slowing. Neurology 57, 542-544. doi: 10.1212/WNL.57.3.542.
53. Samikkannu, T., Rao, K. V., Kanthikeel, S. P., Atluri, V. S., Agudelo, M., Roy, U., et al. (2014). Immunoneuropathogenesis of HIV-1 clades B and C: role of redox expression and thiol modification. Free Radic. Biol. Med. 69, 136-144. doi: 10.1016/j.freeradbiomed.2013.12.025.
54. Shah, A., Kumar, S., Simon, S. D., Singh, D. P., and Kumar, A. (2013). HIV gp120-and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1. Cell Death Dis. 4, e850. doi: 10.1038/cddis.2013.374.
55. Yao, H., Bethel-Brown, C., and Buch, S. (2009). Cocaine Exposure Results in Formation of Dendritic Varicosity in Rat Primary Hippocampal Neurons. Am. J. Infect. Dis. 5, 26-30. doi: 10.3844/ajidsp.2009.26.30.
56. Yi, Y., Lee, C., Liu, Q. H., Freedman, B. D., and Collman, R. G. (2004). Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: implications for neuropathogenesis. J. Neurovirol. 10(Suppl. 1), 91-96. doi: 10.1080/753312758.