Community-onset Klebsiella pneumoniae pneumonia in Taiwan: Clinical features of the disease and associated microbiological characteristics of isolates from pneumonia and nasopharynx

Frontiers in Microbiology

Volumn 6, Issue FEB, 2015, Pages

  Lin, Yi Tsung ^a,b   Wang, Yu Ping ^a   Wang, Fu Der ^a,b   Fung, Chang Phone ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Capsular types; Klebsiella pneumoniae; MLST; Nasopharynx; Pneumonia

Indexed keywords

ADULT; AGED; ANTIBIOTIC SENSITIVITY; ARTICLE; CLINICAL FEATURE; COMMUNITY ACQUIRED PNEUMONIA; FEMALE; GENOTYPE; HUMAN; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; MULTILOCUS SEQUENCE TYPING; NASOPHARYNX; NONHUMAN; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; RISK FACTOR;

KLEBSIELLA PNEUMONIAE;

EID: 84927517382     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00122     Document Type: Article

References (33)

1. Chung, D. R., Park, M. H., Kim, S. H., Ko, K. S., Kang, C. I., Peck, K. R., et al. (2012). Prevalence and molecular characterization of serotype K1 Klebsiella pneumoniae strains from various clinical specimen sources in 11 Asian countries. J. Infect. 64, 622-625. doi: 10.1016/j.jinf.2012.02.007.
2. Cryz, S. J. Jr, Mortimer, P. M., Mansfield, V., and Germanier, R. (1986). Seroepidemiology of Klebsiella bacteremic isolates, and implications for vaccine development. J. Clin. Microbiol. 23, 687-690.
3. Dao, T. T., Liebenthal, D., Tran, T. K., Ngoc Thi Vu, B., Ngoc Thi Nguyen, D., Thi Tran, H. K., et al. (2014). Klebsiella pneumoniae oropharyngeal carriage in rural and urban Vietnam and the effect of alcohol consumption. PLoS ONE 9:e91999. doi: 10.1371/journal.pone.0091999.
4. Decre, D., Verdet, C., Emirian, A., Le Gourrierec, T., Petit, J. C., Offenstadt, G., et al. (2011). Emerging severe and fatal infections due to Klebsiella pneumoniae in two university hospitals in France. J. Clin. Microbiol. 49, 3012-3014. doi: 10.1128/jcm.00676-11.
5. Diancourt, L., Passet, V., Verhoef, J., Grimont, P. A., and Brisse, S. (2005). Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J. Clin. Microbiol. 43, 4178-4182. doi: 10.1128/jcm.43.8.4178-4182.2005.
6. Fang, C. T., Chuang, Y. P., Shun, C. T., Chang, S. C., and Wang, J. T. (2004). A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J. Exp. Med. 199, 697-705. doi: 10.1084/jem.20030857.
7. Fang, C. T., Lai, S. Y., Yi, W. C., Hsueh, P. R., Liu, K. L., and Chang, S. C. (2007). Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin. Infect. Dis. 45, 284-293. doi: 10.1086/519262.
8. Farida, H., Severin, J. A., Gasem, M. H., Keuter, M., Van Den Broek, P., Hermans, P. W., et al. (2013). Nasopharyngeal carriage of Klebsiella pneumoniae and other Gram-negative bacilli in pneumonia-prone age groups in Semarang, Indonesia. J. Clin. Microbiol. 51, 1614-1616. doi: 10.1128/jcm.00589-13.
9. Fine, M. J., Auble, T. E., Yealy, D. M., Hanusa, B. H., Weissfeld, L. A., Singer, D. E., et al. (1997). A prediction rule to identify low-risk patients with community-acquired pneumonia. N. Engl. J. Med. 336, 243-250. doi: 10.1056/nejm199701233360402.
10. Fung, C. P., Chang, F. Y., Lee, S. C., Hu, B. S., Kuo, B. I., Liu, C. Y., et al. (2002). A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis? Gut 50, 420-424. doi: 10.1136/gut.50.3.420.
11. Fung, C. P., Lin, Y. T., Lin, J. C., Chen, T. L., Yeh, K. M., Chang, F. Y., et al. (2012). Klebsiella pneumoniae in gastrointestinal tract and pyogenic liver abscess. Emerg. Infect. Dis. 18, 1322-1325. doi: 10.3201/eid1808.111053.
12. Griffin, A. T., Wiemken, T. L., and Arnold, F. W. (2013). Risk factors for cardiovascular events in hospitalized patients with community-acquired pneumonia. Int. J. Infect. Dis. 17, e1125-e1129. doi: 10.1016/j.ijid.2013.07.005.
13. Hsu, C. R., Lin, T. L., Chen, Y. C., Chou, H. C., and Wang, J. T. (2011). The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited. Microbiology 157, 3446-3457. doi: 10.1099/mic.0.050336-0.
14. Lauderdale, T. L., Chang, F. Y., Ben, R. J., Yin, H. C., Ni, Y. H., Tsai, J. W., et al. (2005). Etiology of community acquired pneumonia among adult patients requiring hospitalization in Taiwan. Respir. Med. 99, 1079-1086. doi: 10.1016/j.rmed.2005.02.026.
15. Liao, C. H., Huang, Y. T., Chang, C. Y., Hsu, H. S., and Hsueh, P. R. (2014). Capsular serotypes and multilocus sequence types of bacteremic Klebsiella pneumoniae isolates associated with different types of infections. Eur. J. Clin. Microbiol. Infect. Dis. 33, 365-369. doi: 10.1007/s10096-013-1964-z.
16. Lin, Y. T., Chen, T. L., Siu, L. K., Hsu, S. F., and Fung, C. P. (2010a). Clinical and microbiological characteristics of community-acquired thoracic empyema or complicated parapneumonic effusion caused by Klebsiella pneumoniae in Taiwan. Eur. J. Clin. Microbiol. Infect. Dis. 29, 1003-1010. doi: 10.1007/s10096-010-0961-8.
17. Lin, Y. T., Jeng, Y. Y., Chen, T. L., and Fung, C. P. (2010b). Bacteremic community-acquired pneumonia due to Klebsiella pneumoniae: clinical and microbiological characteristics in Taiwan, 2001-2008. BMC. Infect. Dis. 10:307. doi: 10.1186/1471-2334-10-307.
18. Lin, Y. T., Liu, C. J., Yeh, Y. C., Chen, T. J., and Fung, C. P. (2013). Ampicillin and amoxicillin use and the risk of Klebsiella pneumoniae liver abscess in Taiwan. J. Infect. Dis. 208, 211-217. doi: 10.1093/infdis/jit157.
19. Lin, Y. T., Wang, F. D., Chan, Y. J., Fu, Y. C., and Fung, C. P. (2014). Clinical and microbiological characteristics of tigecycline non-susceptible Klebsiella pneumoniae bacteremia in Taiwan. BMC. Infect. Dis. 14:1. doi: 10.1186/1471-2334-14-1.
20. Maruyama, T., Fujisawa, T., Okuno, M., Toyoshima, H., Tsutsui, K., Maeda, H., et al. (2013). A new strategy for healthcare-associated pneumonia: a 2-year prospective multicenter cohort study using risk factors for multidrug-resistant pathogens to select initial empiric therapy. Clin. Infect. Dis. 57, 1373-1383. doi: 10.1093/cid/cit571.
21. Paganin, F., Lilienthal, F., Bourdin, A., Lugagne, N., Tixier, F., Genin, R., et al. (2004). Severe community-acquired pneumonia: assessment of microbial aetiology as mortality factor. Eur. Respir. J. 24, 779-785. doi: 10.1183/09031936.04.00119503.
22. Pan, Y. J., Lin, T. L., Chen, Y. H., Hsu, C. R., Hsieh, P. F., Wu, M. C., et al. (2013). Capsular types of Klebsiella pneumoniae revisited by wzc sequencing. PLoS ONE 8:e80670. doi: 10.1371/journal.pone.0080670.
23. Rafat, C., Fihman, V., and Ricard, J. D. (2013). A 51-year-old man presenting with shock and lower-lobe consolidation with interlobar bulging fissure. Chest 143, 1167-1169. doi: 10.1378/chest.12-2007.
24. Rammaert, B., Goyet, S., Beaute, J., Hem, S., Te, V., Try, P. L., et al. (2012). Klebsiella pneumoniae related community-acquired acute lower respiratory infections in Cambodia: clinical characteristics and treatment. BMC. Infect. Dis. 12:3. doi: 10.1186/1471-2334-12-3.
25. Shon, A. S., Bajwa, R. P., and Russo, T. A. (2013). Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence 4, 107-118. doi: 10.4161/viru.22718.
26. Siu, L. K., Fung, C. P., Chang, F. Y., Lee, N., Yeh, K. M., Koh, T. H., et al. (2011). Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan. J. Clin. Microbiol. 49, 3761-3765. doi: 10.1128/jcm.00977-11.
27. Siu, L. K., Yeh, K. M., Lin, J. C., Fung, C. P., and Chang, F.-Y. (2012). Klebsiella pneumoniae liver abscess: a new invasive syndrome. Lancet Infect. Dis. 12, 881-887. doi: 10.1016/S1473-3099(12)70205-0.
28. Song, J. H., Oh, W. S., Kang, C. I., Chung, D. R., Peck, K. R., Ko, K. S., et al. (2008). Epidemiology and clinical outcomes of community-acquired pneumonia in adult patients in Asian countries: a prospective study by the Asian network for surveillance of resistant pathogens. Int. J. Antimicrob. Agents 31, 107-114. doi: 10.1016/j.ijantimicag.2007.09.014.
29. Turton, J. F., Perry, C., Elgohari, S., and Hampton, C. V. (2010). PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets. J. Med. Microbiol. 59, 541-547. doi: 10.1099/jmm.0.015198-0.
30. Wang, J. L., Chen, K. Y., Fang, C. T., Hsueh, P. R., Yang, P. C., and Chang, S. C. (2005). Changing bacteriology of adult community-acquired lung abscess in Taiwan: Klebsiella pneumoniae versus anaerobes. Clin. Infect. Dis. 40, 915-922. doi: 10.1086/428574.
31. Wu, H. S., Wang, F. D., Tseng, C. P., Wu, T. H., Lin, Y. T., and Fung, C. P. (2012). Characteristics of healthcare-associated and community-acquired Klebsiella pneumoniae bacteremia in Taiwan. J. Infect. 64, 162-168. doi: 10.1016/j.jinf.2011.11.005.
32. Yu, V. L., Hansen, D. S., Ko, W. C., Sagnimeni, A., Klugman, K. P., Von Gottberg, A., et al. (2007). Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg. Infect. Dis. 13, 986-993. doi: 10.3201/eid1307.070187.
33. Yu, W. L., Ko, W. C., Cheng, K. C., Lee, H. C., Ke, D. S., Lee, C. C., et al. (2006). Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin. Infect. Dis. 42, 1351-1358. doi: 10.1086/503420.