-
1
-
-
84881296154
-
Phase II and Phase III attrition rates 2011-2012
-
Arrowsmith, J. & Miller, P. Phase II and Phase III attrition rates 2011-2012. Nature Rev. Drug Discov. 12, 569 (2013).
-
(2013)
Nature Rev. Drug Discov.
, vol.12
, pp. 569
-
-
Arrowsmith, J.1
Miller, P.2
-
2
-
-
0024520844
-
Surrogate endpoints in clinical trials: Definition and operational criteria
-
Prentice, R. L. Surrogate endpoints in clinical trials: definition and operational criteria. Stat. Med. 8, 431-440 (1989).
-
(1989)
Stat. Med.
, vol.8
, pp. 431-440
-
-
Prentice, R.L.1
-
3
-
-
34248178511
-
Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: Post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
-
Eijkelkamp, W. B. et al. Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial. J. Am. Soc. Nephrol. 18, 1540-1546 (2007).
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 1540-1546
-
-
Eijkelkamp, W.B.1
-
4
-
-
0035723259
-
Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease
-
Jafar, T. H. et al. Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease. Kidney Int. 60, 1131-1140 (2001).
-
(2001)
Kidney Int.
, vol.60
, pp. 1131-1140
-
-
Jafar, T.H.1
-
5
-
-
4344621497
-
Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy
-
de Zeeuw, D. et al. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation 110, 921-927 (2004).
-
(2004)
Circulation
, vol.110
, pp. 921-927
-
-
De Zeeuw, D.1
-
6
-
-
0035806626
-
Effect of statin therapy on C-reactive protein levels: The pravastatin inflammation/CRP evaluation (PRINCE): A randomized trial and cohort study
-
Albert, M. A., Danielson, E., Rifai, N. & Ridker, P. M. Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study. JAMA 286, 64-70 (2001).
-
(2001)
JAMA
, vol.286
, pp. 64-70
-
-
Albert, M.A.1
Danielson, E.2
Rifai, N.3
Ridker, P.M.4
-
7
-
-
84883750690
-
Effects of atorvastatin and rosuvastatin on renal function: A meta-analysis
-
Savarese, G. et al. Effects of atorvastatin and rosuvastatin on renal function: a meta-analysis. Int. J. Cardiol. 167, 2482-2489 (2013).
-
(2013)
Int. J. Cardiol.
, vol.167
, pp. 2482-2489
-
-
Savarese, G.1
-
8
-
-
63649095045
-
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial
-
Ridker, P. M. et al. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 373, 1175-1182 (2009).
-
(2009)
Lancet
, vol.373
, pp. 1175-1182
-
-
Ridker, P.M.1
-
9
-
-
19944433033
-
Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: A randomized, placebo-controlled trial
-
De Jager, J. et al. Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J. Intern. Med. 257, 100-109 (2005).
-
(2005)
J. Intern. Med.
, vol.257
, pp. 100-109
-
-
De Jager, J.1
-
10
-
-
77953857048
-
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
-
Bailey, C. J., Gross, J. L., Pieters, A., Bastien, A. & List, J. F. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 375, 2223-2233 (2010).
-
(2010)
Lancet
, vol.375
, pp. 2223-2233
-
-
Bailey, C.J.1
Gross, J.L.2
Pieters, A.3
Bastien, A.4
List, J.F.5
-
11
-
-
80155124676
-
Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
-
Nauck, M. A. et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care 34, 2015-2022 (2011).
-
(2011)
Diabetes Care
, vol.34
, pp. 2015-2022
-
-
Nauck, M.A.1
-
12
-
-
79953787215
-
Increased serum potassium affects renal outcomes: A post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
-
Miao, Y. et al. Increased serum potassium affects renal outcomes: a post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial. Diabetologia 54, 44-50 (2011).
-
(2011)
Diabetologia
, vol.54
, pp. 44-50
-
-
Miao, Y.1
-
13
-
-
34249897487
-
Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: A randomized controlled study of benazepril and losartan in chronic renal insufficiency
-
Hou, F. F. et al. Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency. J. Am. Soc. Nephrol. 18, 1889-1898 (2007).
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 1889-1898
-
-
Hou, F.F.1
-
14
-
-
84896697373
-
The effect of ramipril and telmisartan on serum potassium and its association with cardiovascular and renal events: Results from the ONTARGET trial
-
Lambers Heerspink, H. J. et al. The effect of ramipril and telmisartan on serum potassium and its association with cardiovascular and renal events: results from the ONTARGET trial. Eur. J. Prev. Cardiol. 21, 299-309 (2014).
-
(2014)
Eur. J. Prev. Cardiol.
, vol.21
, pp. 299-309
-
-
Lambers Heerspink, H.J.1
-
15
-
-
84893805586
-
The importance of short-term off-target effects in estimating the long-term renal and cardiovascular protection of angiotensin receptor blockers
-
Smink, P. A. et al. The importance of short-term off-target effects in estimating the long-term renal and cardiovascular protection of angiotensin receptor blockers. Clin. Pharmacol. Ther. 95, 208-215 (2014).
-
(2014)
Clin. Pharmacol. Ther.
, vol.95
, pp. 208-215
-
-
Smink, P.A.1
-
16
-
-
84896465696
-
A prediction of the renal and cardiovascular efficacy of aliskiren in ALTITUDE using short-term changes in multiple risk markers
-
Smink, P. A. et al. A prediction of the renal and cardiovascular efficacy of aliskiren in ALTITUDE using short-term changes in multiple risk markers. Eur. J. Preventive Cardiol. 21, 434-441 (2014).
-
(2014)
Eur. J. Preventive Cardiol.
, vol.21
, pp. 434-441
-
-
Smink, P.A.1
|