Ventilation/perfusion distribution abnormalities in morbidly obese subjects before and after bariatric surgery

Chest

Volumn 147, Issue 4, 2015, Pages 1127-1134

  Rivas, Eva ^a   Arismendi, Ebymar ^a   Agustí, Alvar ^a   Sanchez, Marcelo ^a   Delgado, Salvadora ^a   Gistau, Concepción ^a   Wagner, Peter D ^b   Rodriguez Roisin, Roberto ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; CARBON MONOXIDE; FIBRINOGEN; INTERLEUKIN 8; LEPTIN; OXYGEN; TUMOR NECROSIS FACTOR RECEPTOR 1; CARBON DIOXIDE;

ADULT; AGE; AMBIENT AIR; APNEA HYPOPNEA INDEX; ARTERIAL OXYGEN TENSION; ARTICLE; ATELECTASIS; BARIATRIC SURGERY; BLOOD CARBON DIOXIDE TENSION; BLOOD FLOW; BODY MASS; BODY WEIGHT; BREATHING; BREATHING DISORDER; CARBON MONOXIDE BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; EXPIRATORY RESERVE VOLUME; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FUNCTIONAL RESIDUAL CAPACITY; HEART INDEX; HEART OUTPUT; HUMAN; HYPERTENSION; HYPOXIC LUNG VASOCONSTRICTION; INERT GAS EXCHANGE; INTERMETHOD COMPARISON; LEUKOCYTE COUNT; LUNG ALVEOLUS OXYGEN TENSION; LUNG ARTERY PRESSURE; LUNG GAS EXCHANGE; LUNG HEMODYNAMICS; LUNG VASCULAR RESISTANCE; LUNG VENTILATION DISTRIBUTION; LUNG VOLUME; METABOLIC SYNDROME X; MORBID OBESITY; NEUTROPHIL COUNT; OXYGEN BREATHING; OXYGEN TENSION; PH; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ROUX Y ANASTOMOSIS; SHUNTING; SLEEVE GASTRECTOMY; SMOKING; SPIROMETRY; TOTAL LUNG CAPACITY; TREATMENT OUTCOME; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WEIGHT REDUCTION; BLOOD; BLOOD GAS ANALYSIS; COMPARATIVE STUDY; FOLLOW UP; LUNG; LUNG VENTILATION PERFUSION RATIO; MIDDLE AGED; OBESITY, MORBID; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY;

BARIATRIC SURGERY; BLOOD GAS ANALYSIS; CARBON DIOXIDE; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG; MIDDLE AGED; OBESITY, MORBID; OXYGEN; PROSPECTIVE STUDIES; RESPIRATION; VENTILATION-PERFUSION RATIO;

EID: 84927144379     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.14-1749     Document Type: Article

References (29)

1. World Health Organization Global Health Observatory. Obesity: situation and trends. World Health Organization website. http://www.who.int/gho/ncd/risk-factors/obesity-text/en/. Accessed June 12, 2014.
2. Finucane MM , Stevens GA , Cowan MJ ,et al; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional, and global trends in body-mass index since 1980: systematic analysis of healthexamination surveys andepidemiological studies with 960 country-years and 9·1 million participants . Lancet. 2011; 377 (9765): 557-567.
3. Flum DR , Belle SH , King WC ,et al; Longitudinal Assessment of Bariatric Surgery (LABS) Consortium. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med. 2009; 361 (5): 445-454.
4. Colquitt JL, Picot J, Loveman E, Clegg AJ. Surgery for obesity. Cochrane Database Syst Rev. 2009 ;(2): CD003641.
5. Jones RL , Nzekwu MM. Theeffects of body mass index on lung volumes. Chest. 2006; 130 (3): 827-833.
6. Salome CM , King GG , Berend N. Physiology of obesity andeffects on lung function. J Appl Physiol (1985). 2010; 108 (1): 206-211.
7. Holley HS , Milic-Emili J , Becklake MR , Bates DV. Regional distribution of pulmonary ventilation and perfusion in obesity. J Clin Invest. 1967; 46 (4): 475-481.
8. Rivas E , Arismendi E , Sanchez M ,et al. Ventilation-perfusion imbalance, systemic inflammation and lung imaging in severe obesity before and after bariatric surgery. Am J Respir Crit Care Med. 2014; 189: A5387.
9. AASM. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep. 1999; 22 (5): 667-689.
10. Roca J , Sanchis J , Agusti-Vidal A ,et al. Spirometric reference values from a Mediterranean population. Bull Eur Physiopathol Respir. 1986; 22 (3): 217-224.
11. Roca J , Rodriguez-Roisin R , Cobo E , Burgos F, Perez J, Clausen JL. Single-breath carbon monoxide diff using capacity prediction equations from a Mediterranean population. Am Rev Respir Dis. 1990; 141 (4 pt 1): 1026-1032.
12. Roca J , Burgos F , Barberà JA ,et al. Predictionequations for plethysmographic lung volumes. Respir Med. 1998; 92 (3): 454-460.
13. Polverino E, Gómez FP, Manrique H,et al. Gasexchange response to short-acting beta2-agonists in chronic obstructive pulmonary disease severeexacerbations. Am J Respir Crit Care Med. 2007; 176 (4): 350-355.
14. Roca J , Wagner PD. Contribution of multiple inert gaselimination technique to pulmonary medicine. 1. Principles and information content of the multiple inert gaselimination technique. Thorax. 1994; 49 (8): 815-824.
15. Brown CV , Martin MJ , Shoemaker WC ,et al. Theeffect of obesity on bioimpedance cardiac index. Am J Surg. 2005; 189 (5): 547-550.
16. Cardús J , Burgos F , Diaz O ,et al. Increase in pulmonary ventilation-perfusion inequality with age in healthy individuals. Am J Respir Crit Care Med. 1997; 156 (2 pt 1): 648-653.
17. Gale GE , Torre-Bueno JR , Moon RE , Saltzman HA , Wagner PD. Ventilationperfusion inequality in normal humans duringexercise at sea level and simulated altitude. J Appl Physiol (1985). 1985; 58 (3): 978-988.
18. Leone N , Courbon D , Thomas F ,et al. Lung function impairment and metabolic syndrome: the critical role of abdominal obesity. Am J Respir Crit Care Med. 2009; 179 (6): 509-516.
19. Wehrmeister FC , Menezes AM , Muniz LC , Martínez-Mesa J , Domingues MR , Horta BL. Waist circumference and pulmonary function: a systematic review and meta-analysis. Syst Rev. 2012; 1: 55.
20. Zavorsky GS , Hoff man SL. Pulmonary gasexchange in the morbidly obese. Obes Rev. 2008; 9 (4): 326-339.
21. Gabrielsen AM , Lund MB , Kongerud J , Viken KE , Røislien J , Hjelmesæth J. The relationship between anthropometric measures, blood gases, and lung function in morbidly obese white subjects. Obes Surg. 2011; 21 (4): 485-491.
22. Barrera F , Reidenberg MM , Winters WL , Hungspreugs S. Ventilation-perfusion relationships in the obese patient. J Appl Physiol. 1969; 26 (4): 420-426.
23. Agustí AG , Cardús J , Roca J , Grau JM , Xaubet A , Rodriguez-Roisin R. Ventilation-perfusion mismatch in patients with pleuraleff usion:effects of thoracentesis. Am J Respir Crit Care Med. 1997; 156 (4 pt 1): 1205-1209.
24. Aghamohammadzadeh R, Greenstein AS, Yadav R ,et al. Effects of bariatric surgery on human small artery function:evidence for reduction in perivascular adipocyte inflammation, and the restoration of normal anticontractile activity despite persistent obesity. J Am Coll Cardiol. 2013; 62 (2): 128-135.
25. Dantzker DR , Wagner PD , West JB. Instability of lung units with low Va/Q ratios during O2 breathing. J Appl Physiol. 1975; 38 (5): 886-895.
26. Santos C , Ferrer M , Roca J , Torres A , Hernández C , Rodriguez-Roisin R. Pulmonary gasexchange response to oxygen breathing in acute lung injury. Am J Respir Crit Care Med. 2000; 161 (1): 26-31.
27. Greenstein AS , Khavandi K , Withers SB ,et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation. 2009; 119 (12): 1661-1670.
28. Zavorsky GS , Wilson B. Sex, girth, waists and hips (what matters for gasexchange inextreme obesity?). Respir Physiol Neurobiol. 2010; 170 (1): 120-122.
29. Zavorsky GS , Christou NV , Kim do J , Carli F , Mayo NE. Preoperative gender differences in pulmonary gasexchange in morbidly obese subjects. Obes Surg. 2008; 18 (12): 1587-1598.