Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for the detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging

Journal of Neurotrauma

Volumn 32, Issue 8, 2015, Pages 527-533

  McMahon, Paul J ^a   Panczykowski, David M ^a   Yue, John K ^b   Puccio, Ava M ^a   Inoue, Tomoo ^b   Sorani, Marco D ^b   Lingsma, Hester F ^d   Maas, Andrew I R ^e   Valadka, Alex B ^f   Yuh, Esther L ^c   Mukherjee, Pratik ^c   Manley, Geoffrey T ^b   Okonkwo, David O ^a   Casey, Scott S ^b   Cheong, Maxwell ^c   Cooper, Shelly R ^b   Dams O'Connor, Kristen ^g   Gordon, Wayne A ^g   Hricik, Allison J ^a   Lawless, Kerri ^a   Menon, David ^h   Schnyer, David M ⁱ   Vassar, Mary J ^b   more..

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^f Seton Brain and Spine Institute   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF CAMBRIDGE   (United Kingdom)

ⁱ UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

biomarkers; imaging; traumatic brain injury

Indexed keywords

BIOLOGICAL MARKER; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN AND BREAKDOWN PRODUCT; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; AMNESIA; ARTICLE; COHORT ANALYSIS; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONSCIOUSNESS DISORDER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ELISA KIT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GLASGOW COMA SCALE; HUMAN; INJURY SCALE; INJURY SEVERITY; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIPLE TRAUMA; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OUTCOME ASSESSMENT; POSTTRAUMATIC COMPLICATION; PRACTICE GUIDELINE; PREDICTIVE VALUE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PUPIL REFLEX; SCREENING; SENSITIVITY AND SPECIFICITY; TRAUMATIC BRAIN INJURY; UNCONSCIOUSNESS; BLOOD; BRAIN INJURIES; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; MIDDLE AGED; REPRODUCIBILITY; SEVERITY OF ILLNESS INDEX; SINGLE BLIND PROCEDURE; VERY ELDERLY; X-RAY COMPUTED TOMOGRAPHY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; BRAIN INJURIES; CHILD; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 84926660913     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2014.3635     Document Type: Article

References (23)

1. Stocchetti, N., Pagan, F., Calappi, E., Canavesi, K., Beretta, L., Citerio, G., Cormio, M., Colombo, A. (2004). Inaccurate early assessment of neurological severity in head injury. J. Neurotrauma 21, 1131-1140.
2. Vos, P.E., Lamers, K.J., Hendriks, J.C., van Haaren, M., Beems, T., Zimmerman, C., van Geel, W., de Reus, H., Biert, J., and Verbeek, M.M. (2004). Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury. Neurology 62, 1303-1310.
3. Papa, L., Lewis, L.M., Silvestri, S., Falk, J.L., Giordano, P., Brophy, G.M., Demery, J.A., Liu, M.C., Mo, J., Akinyi, L., Mondello, S., Schmid, K., Robertson, C.S., Tortella, F.C., Hayes, R.L., and Wang, K.K. (2012). Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention. J. Trauma Acute Care Surg. 72, 1335-1344.
4. Eng, L.F., Ghirnikar, R.S., and Lee, Y.L. (2000). Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem. Res. 25, 1439-1451.
5. Lee, Y.B., Du, S., Rhim, H., Lee, E.B., Markelonis, G.J., and Oh, T.H. (2000). Rapid increase in immunoreactivity to GFAP in astrocytes in vitro induced by acidic pH is mediated by calcium influx and calpain I. Brain Res. 864, 220-229.
6. Okonkwo, D.O., Yue, J.K., Puccio, A.M., Panczykowski, D., Inoue, T., McMahon, P.J., Sorani, M.D., Yuh, E.L., Lingsma, H., Maas, A., Valadka, A. and Manley, G.T.; Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. (2013). GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective TRACK-TBI Study. J. Neurotrauma 30, 1490-1497.
7. Yue, J.K., Vassar, M.J., Lingsma, H.F., Cooper, S.R., Okonkwo, D.O., Valadka, A.B., Gordon, W.A., Maas, A.I., Mukherjee, P., Yuh, E.L., Puccio, A.M., Schnyer, D.M., Manley, G.T., Track-Tbi, I., Casey, S.S., Cheong, M., Dams-O'Connor, K., Hricik, A.J., Knight, E.E., Kulubya, E.S., Menon, D.K., Morabito, D.J., Pacheco, J.L., and Sinha, T.K. (2013). Transforming research and clinical knowledge in traumatic brain injury pilot: multicenter implementation of the common data elements for traumatic brain injury. J. Neurotrauma 30, 1831-1844.
8. Jagoda, A.S., Bazarian, J.J., Bruns, J.J., Jr., Cantrill, S.V., Gean, A.D., Howard, P.K., Ghajar, J., Riggio, S., Wright, D.W., Wears, R.L., Bakshy, A., Burgess, P., Wald, M.M., and Whitson, R.R.; American College of Emergency Physicians, Centers for Disease Control and Prevention. (2008). Clinical policy: neuroimaging and decisionmaking in adult mild traumatic brain injury in the acute setting. Ann. Emerg. Med. 52, 714-748.
9. Manley, G.T., Diaz-Arrastia, R., Brophy, M., Engel, D., Goodman, C., Gwinn, K., Veenstra, T.D., Ling, G., Ottens, A.K., Tortella, F., and Hayes, R.L. (2010). Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group. Arch. Phys. Med. Rehabil. 91, 1667-1672.
10. Zoltewicz, J.S., Scharf, D., Yang, B., Chawla, A., Newsom, K.J., and Fang, L. (2012). Characterization of antibodies that detect human GFAP after traumatic brain injury. Biomark. Insights 7, 71-79.
11. Papa, L., Lewis, L.M., Falk, J.L., Zhang, Z., Silvestri, S., Giordano, P., Brophy, G.M., Demery, J.A., Dixit, N.K., Ferguson, I., Liu, M.C., Mo, J., Akinyi, L., Schmid, K., Mondello, S., Robertson, C.S., Tortella, F.C., Hayes, R.L., and Wang, K.K. (2012). Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Ann. Emerg. Med. 59, 471-483.
12. Duhaime, A.C., Gean, A.D., Haacke, E.M., Hicks, R., Wintermark, M., Mukherjee, P., Brody, D., Latour, L., and Riedy, G.; Common Data Elements Neuroimaging Working Group Members, Pediatric Working Group Members. (2010). Common data elements in radiologic imaging of traumatic brain injury. Arch. Phys. Med. Rehabil. 91, 1661-1666.
13. Whyte, J., Vasterling, J., and Manley, G.T. (2010). Common data elements for research on traumatic brain injury and psychological health: current status and future development. Arch. Phys. Med. Rehabil. 91, 1692-1696.
14. Vickers, A.J., and Elkin, E.B. (2006). Decision curve analysis: a novel method for evaluating prediction models. Med. Decis. Making 26, 565-574.
15. Papa, L., Stiell, I.G., Clement, C.M., Pawlowicz, A., Wolfram, A., Braga, C., Draviam, S., and Wells, G.A. (2012). Performance of the Canadian CT Head Rule and the New Orleans Criteria for predicting any traumatic intracranial injury on computed tomography in a United States Level I trauma center. Acad. Emerg. Med. 19, 2-10.
16. Mondello, S., Muller, U., Jeromin, A., Streeter, J., Hayes, R.L., and Wang, K.K. (2011). Blood-based diagnostics of traumatic brain injuries. Exp. Rev. Mol. Diagn. 11, 65-78.
17. Honda, M., Tsuruta, R., Kaneko, T., Kasaoka, S., Yagi, T., Todani, M., Fujita, M., Izumi, T., and Maekawa, T. (2010). Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. J. Trauma 69, 104-109.
18. Pelinka, L.E., Kroepfl, A., Leixnering, M., Buchinger, W., Raabe, A., and Redl, H. (2004). GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. J. Neurotrauma 21, 1553-1561.
19. Mondello, S., Papa, L., Buki, A., Bullock, M.R., Czeiter, E., Tortella, F.C., Wang, K.K., and Hayes, R.L. (2011). Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. Crit. Care 15, R156.
20. Stiell, I.G., Clement, C.M., Rowe, B.H., Schull, M.J., Brison, R., Cass, D., Eisenhauer, M.A., McKnight, R.D., Bandiera, G., Holroyd, B., Lee, J.S., Dreyer, J., Worthington, J.R., Reardon, M., Greenberg, G., Lesiuk, H., MacPhail, I., and Wells, G.A. (2005). Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury. JAMA 294, 1511-1518.
21. Smits, M., Dippel, D.W., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, D.R., van Rijssel, D.A., Hofman, P.A., Twijnstra, A., Tanghe, H.L., and Hunink, M.G. (2010). Minor head injury: CT-based strategies for management-A cost-effectiveness analysis. Radiology 254, 532-540.
22. Ruan, S., Noyes, K., and Bazarian, J.J. (2009). The economic impact of S-100B as a pre-head CT screening test on emergency department management of adult patients with mild traumatic brain injury. J. Neurotrauma 26, 1655-1664.
23. Hunink, M.G. (2005). Decision making in the face of uncertainty and resource constraints: examples from trauma imaging. Radiology 235, 375-383.