DFS70/LEDGFp75: An enigmatic autoantigen at the interface between autoimmunity, AIDS, and cancer

Frontiers in Immunology

Volumn 6, Issue MAR, 2015, Pages

  Basu, Anamika ^a   Sanchez, Tino W ^a   Casiano, Carlos A ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoantibodies; Autoantigens; Autoimmunity; Cancer; DFS70; HIV; LEDGFp75

Indexed keywords

LENS EPITHELIUM DERIVED GROWTH FACTOR; LENS EPITHELIUM DERIVED GROWTH FACTOR P75; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; DISEASE ASSOCIATION; EYE DISEASE; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOFLUORESCENCE; IMMUNOGENICITY; INFLAMMATION; NEOPLASM; PROTEIN EXPRESSION; PROTEIN STRUCTURE; QUANTITATIVE ASSAY; SIGNAL TRANSDUCTION; SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASE;

EID: 84926651155     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00116     Document Type: Article

References (15)

1. Ochs RL, Muro Y, Si Y, Ge H, Chan EK, Tan EM. Autoantibodies to DFS70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. J Allergy Clin Immunol (2000) 105:1211-20. doi: 10.1067/mai.2000.107039
2. Ganapathy V, Casiano CA. Autoimmunity to the nuclear autoantigen DFS70 (LEDGF): what exactly are the autoantibodies trying to tell us? Arthritis Rheum (2004) 50:684-8. doi:10.1002/art.20095
3. Mahler M, Fritzler MJ. The clinical significance of the dense fine speckled immunofluorescence pattern on HEp-2 cells for the diagnosis of systemic autoimmune diseases. Clin Dev Immunol (2012) 2012:494356. doi:10.1155/2012/494356
4. Dellavance A, Viana VS, Leon EP, Bonfa ES, Andrade LE, Leser PG. The clinical spectrum of antinuclear antibodies associated with the nuclear dense fine speckled immunofluorescence pattern. J Rheumatol (2005) 32:2144-9.
5. Miyara M, Albesa R, Charuel JL, El Amri M, Fritzler MJ, Ghillani-Dalbin P, et al. Clinical phenotypes of patients with anti-DFS70/LEDGF antibodies in a routine ANA referral cohort. Clin Dev Immunol (2013) 2013:703759. doi:10.1155/2013/703759
6. Mariz HA, Sato EI, Barbosa SH, Rodrigues SH, Dellavance A, Andrade LE. Pattern on the antinuclear antibody-HEp-2 test is a critical parameter for discriminating antinuclear antibody-positive healthy individuals and patients with autoimmune rheumatic diseases. Arthritis Rheum (2011) 63:191-200. doi:10.1002/art.30084
7. Mahler M, Parker T, Peebles CL, Andrade LE, Swart A, Carbone Y, et al. Anti-DFS70/LEDGF antibodies are more prevalent in healthy individuals compared to patients with systemic autoimmune rheumatic diseases. J Rheumatol (2012) 39:2104-10. doi:10.3899/jrheum.120598
8. Basu A, Rojas H, Banerjee H, Cabrera IB, Perez KY, De León M, et al. Expression of the stress response oncoprotein LEDGF/p75 in human cancer: a study of 21 tumor types. PLoS One (2012) 7:e30132. doi:10.1371/journal.pone.0030132
9. Leitz J, Reuschenbach M, Lohrey C, Honegger A, Accardi R, Tommasino M, et al. Oncogenic human papillomaviruses activate the tumor-associated lens epithelial-derived growth factor (LEDGF) gene. PLoS Pathog (2014) 10:e1003957. doi:10.1371/journal.ppat.1003957
10. Leoh LS, Mediavilla-Varela M, Basu A, Casiano CA. Autoantibodies to LEDGFp75/DFS70: natural autoantibodies or sensors of an augmented state of cellular oxidative stress. In: Conrad K, Chan EKL, Fritzler MJ, Humbel RL, von Landenberg P, Shoenfeld Y, editors. "From Pathogenesis to Therapy of Autoimmune Diseases" Autoimmunity, Autoantigens, and Autoantibodies. (Vol. 6), Lengerich: PABST Science Publishers (2009). p. 137-55.
11. Debyser Z, Christ F, De Rijck J, Gijsbers R. Host factors for retroviral integration site selection. Trends Biochem Sci (2014) 40:108-16. doi:10.1016/j.tibs.2014.12.001
12. Ogawa Y, Sugiura K, Watanabe A, Kunimatsu M, Mishima M, Tomita Y, et al. Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain. J Autoimmun (2004) 23:221-31. doi:10.1016/j.jaut.2004.07.003
13. Shinohara T, Singh DP, Fatma N. LEDGF, a survival factor, activates stress-related genes. Prog Retin Eye Res (2002) 21:341-58. doi:10.1016/S1350-9462(02)00007-1
14. Basu A, Drame A, Muñoz R, Gijsbers R, Debyser Z, De Leon M, et al. Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in PCa cells. Prostate (2012) 72:597-611. doi:10.1002/pros.21463
15. Sutherland HG, Newton K, Brownstein DG, Holmes MC, Kress C, Semple CA, et al. Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. Mol Cell Biol (2006) 26:7201-10. doi:10.1128/MCB.00459-06