Postoperative impaired glucose tolerance is an early predictor of pancreas graft failure

Diabetologia

Volumn 57, Issue 10, 2014, Pages 2076-2080

  Mittal, Shruti ^a,b,c   Nagendran, Myura ^d   Franklin, Rachel H ^a   Sharples, Edward J ^b,e   Friend, Peter J ^a,e   Gough, Stephen C L ^b,c  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Metabolic biomarkers; Pancreas transplant; Risk factors; Survival; Transplant outcome; Type 1 diabetes

Indexed keywords

ALEMTUZUMAB; GLUCOSE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; BLOOD SAMPLING; COLD ISCHEMIA; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FAILURE; KIDNEY GRAFT REJECTION; KIDNEY PANCREAS TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; PANCREAS TRANSPLANTATION; POSTOPERATIVE PERIOD; PREDICTIVE VALUE; PRIORITY JOURNAL; SEX DIFFERENCE; BLOOD; COMPLICATION; DIABETES MELLITUS, TYPE 1; GLUCOSE INTOLERANCE; METABOLISM; MIDDLE AGED; PANCREAS; RETROSPECTIVE STUDY; RISK FACTOR;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCOSE INTOLERANCE; GRAFT SURVIVAL; HUMANS; MALE; MIDDLE AGED; PANCREAS; PANCREAS TRANSPLANTATION; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84926639613     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3320-y     Document Type: Article

References (9)

1. Gruessner RW, Gruessner AC (2013) The current state of pancreas transplantation. Nat Rev Endocrinol 9:555-562
2. Axelrod DA, Sung RS, Meyer KH, Wolfe RA, Kaufman DB (2010) Systematic evaluation of pancreas allograft quality, outcomes and geographic variation in utilization. Am J Transplant 10:837-845
3. Dieterle CD, Veitenhansl M, Gutt B et al (2007) Impaired glucose tolerance in pancreas grafted diabetic patients is due to insulin secretory defects. Exp Clin Endocrinol Diabetes 115:647-653
4. Gruessner AC, Sutherland DE, Gruessner RW (2012) Long-term outcome after pancreas transplantation. Curr Opin Organ Transplant 17:100-105
5. Pfeffer F, Nauck MA, Drognitz O, Benz S, von Dobschuetz E, Hopt UT (2003) Postoperative oral glucose tolerance and stimulated insulin secretion: a predictor of endocrine graft function more than 10 years after pancreas-kidney transplantation. Transplantation 76:1427-1431
6. Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539-553
7. Battezzati A, Benedini S, Caldara R et al (2001) Prediction of the longterm metabolic success of the pancreatic graft function. Transplantation 71:1560-1565
8. Baitello M, Galante NZ, Coutinho Lde S et al (2011) Impact of delayed pancreatic graft function in simultaneous pancreas-kidney transplantation. J Bras Nefrol 33:180-188
9. Sosenko JM, Skyler JS, Herold KC, Palmer JP (2012) The metabolic progression to type 1 diabetes as indicated by serial oral glucose tolerance testing in the Diabetes Prevention Trial-Type 1. Diabetes 61:1331-1337