Identification of a novel fosXCC gene conferring fosfomycin resistance in Campylobacter

Journal of Antimicrobial Chemotherapy

Volumn 70, Issue 4, 2014, Pages 1261-1263

  Wang, Yang ^a   Yao, Hong ^a   Deng, Fengru ^a   Liu, Dejun ^a   Zhang, Yi ^b   Shen, Zhangqi ^c  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c IOWA STATE UNIVERSITY   (United States)

Author keywords

Food safety; Food producing animal; Foodborne pathogens; Multidrug resistance

Indexed keywords

FOSFOMYCIN; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL GENE; BACTERIAL STRAIN; CAMPYLOBACTER; CAMPYLOBACTER COLI; CAMPYLOBACTER JEJUNI; CATALYSIS; ESCHERICHIA COLI; FOSX GENE; GENOMIC ISLAND; HUMAN; LETTER; LISTERIA MONOCYTOGENES; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PREDICTION; PROMOTER REGION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; SERRATIA MARCESCENS; STAPHYLOCOCCUS HAEMOLYTICUS; ANIMAL; CAMPYLOBACTERIOSIS; CHINA; DRUG EFFECTS; FECES; GENETICS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PIG; SWINE DISEASE; VETERINARY;

ANIMALS; ANTI-BACTERIAL AGENTS; CAMPYLOBACTER; CAMPYLOBACTER INFECTIONS; CHINA; DRUG RESISTANCE, BACTERIAL; FECES; FOSFOMYCIN; GENES, BACTERIAL; MICROBIAL SENSITIVITY TESTS; SWINE; SWINE DISEASES;

EID: 84926454979     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku488     Document Type: Letter

References (15)

1. Forsgren A, Walder M. Antimicrobial activity of fosfomycin in vitro. J Antimicrob Chemother 1983; 11: 467-71.
2. Fillgrove KL, Pakhomova S, Newcomer ME et al. Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms. J Am Chem Soc 2003; 125: 15730-1.
3. Karageorgopoulos DE, Wang R, Yu XH et al. Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens. J Antimicrob Chemother 2012; 67: 255-68.
4. Kobayashi S, Kuzuyama T, Seto H. Characterization of the fomA and fomB gene products from Streptomyces wedmorensis, which confer fosfomycin resistance on Escherichia coli. Antimicrob Agents Chemother 2000; 44: 647-50.
5. Ruiz-Palacios GM. The health burden of Campylobacter infection and the impact of antimicrobial resistance: playing chicken. Clin Infect Dis 2007; 44: 701-3.
6. Engberg J, Aarestrup FM, Taylor DE et al. Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. Emerg Infect Dis 2001; 7: 24-34.
7. Luangtongkum T, Jeon B, Han J et al. Antibiotic resistance in Campylobacter: emergence, transmission and persistence. Future Microbiol 2009; 4: 189-200.
8. Nogawa T, Takeuchi Y, Watanabe J et al. Clinical trial of fosfomycin for Campylobacter enteritis. Jpn J Antibiotics 1984; 37: 1620-4.
9. Wang Y, Zhang M, Deng F et al. Emergence of multidrug-resistant Campylobacter species isolates with a horizontally acquired rRNA methylase. Antimicrob Agents Chemother 2014; 58: 5405-12.
10. Navas J, Leon J, Arroyo M et al. Nucleotide sequence and intracellular location of the product of the fosfomycin resistance gene from transposon Tn2921. Antimicrob Agents Chemother 1990; 34: 2016-8.
11. Arca P, Reguera G, Hardisson C. Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicentre survey. J Antimicrob Chemother 1997; 40: 393-9.
12. Arnold K, Bordoli L, Kopp J et al. The SWISS-MODEL workspace: a webbased environment for protein structure homology modelling. Bioinformatics 2006; 22: 195-201.
13. Fillgrove KL, Pakhomova S, Schaab MR et al. Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes. Biochemistry 2007; 46: 8110-20.
14. Karlyshev AV, Wren BW. Development and application of an insertional system for gene delivery and expression in Campylobacter jejuni. Appl Environ Microbiol 2005; 71: 4004-13.
15. Parkhill J, Wren BW, Mungall K et al. The genome sequence of the foodborne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 2000; 403: 665-8.