β-Catenin: A Key Player in Both Cell Adhesion and Wnt Signaling

Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions

Volumn , Issue , 2014, Pages 217-224

  Pettitt, Jonathan ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Cell adhesion; Drosophila; Wnt signaling; catenin

Indexed keywords

EID: 84926444181     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118444122.ch16     Document Type: Chapter

References (55)

1. Bahmanyar, S., Kaplan, D.D., Deluca, J.G. et al. (2008). beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes & Development, 22, 91-105.
2. Bienz, M. (2006) The PHD finger, a nuclear proteininteraction domain. Trends in Biochemical Science, 31, 35-40.
3. Brack, A.S., Murphy-Seiler, F., Hanifi, J. et al. (2009). BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Developmental Biology, 335, 1-51.
4. Brasch, J., Harrison, O.J., Honig, B., and Shapiro, L. (2012) Thinking outside the cell: how cadherins drive adhesion. Trends in Cell Biology, 22, 299-310.
5. Brembeck, F.H., Schwarz-Romond, T., Bakkers, J. et al. (2004). Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes & Development, 18, 2225-2230.
6. Bustos, V.H., Ferrarese, A., Venerando, A. et al. (2006). The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1. Proceedings of the National Academy of Sciences of the United States of America, 103, 19725-19730.
7. Butz, S., Stappert, J., Weissig, H., and Kemler, R. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science, 257, 1142-1144.
8. Chai, G., Ma, C., Bao, K. et al. (2010). Complete functional segregation of planarian-catenin-1 and -2 in mediating Wnt signaling and cell adhesion. The Journal of Biological Chemistry, 285, 24120-24130.
9. Chilov, D., Sinjushina, N., Rita, H. et al. (2011). Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain. Developmental Biology, 357, 259-268.
10. Costa, M., Raich, W., Agbunag, C. et al. (1998). A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. The Journal of Cell Biology, 141, 297-308.
11. Deka, J., Wiedemann, N., Anderle, P. et al. (2010). Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Cancer Research, 70, 6619-6628.
12. Dickinson, D.J., Nelson, W.J., and Weis, W.I. (2011) A polarized epithelium organized by beta-and alphacatenin predates cadherin and metazoan origins. Science, 331, 1336-1339.
13. Fiedler, M., Sánchez-Barrena, M.J., Nekrasov, M. et al. (2008). Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Molecular Cell, 30, 507-518.
14. Funayama, N., Fagotto, F., McCrea, P., and Gumbiner, B.M. (1995) Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling. The Journal of Cell Biology, 128, 959-968.
15. Gottardi, C.J. and Gumbiner, B.M. (2004) Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. The Journal of Cell Biology, 167, 339-349.
16. Gottardi, C.J. and Peifer, M. (2008) Terminal regions of beta-catenin come into view. Structure, 16, 336-338.
17. Grimson, M.J., Coates, J.C., Reynolds, J.P. et al. (2000). Adherens junctions and beta-catenin-mediated cell signalling in a non-metazoan organism. Nature, 408, 727-731.
18. Gu, B., Sun, P., Yuan, Y. et al. (2009). Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. The Journal of Cell Biology, 185, 811-826.
19. Hadjihannas, M.V., Brückner, M., and Behrens, J. (2010) Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Reports, 11, 317-324.
20. Hiroki, O. (2012) Evolution of the cadherin-catenin complex. Subcellular Biochemistry, 60, 9-35.
21. Hoffmans, R. and Basler, K. (2004) Identification and in vivo role of the Armadillo-Legless interaction. Development, 131, 4393-4400.
22. Hoffmans, R. and Basler, K. (2007) BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. Mechanisms of Development, 124, 59-67.
23. Huang, P., Senga, T., and Hamaguchi, M. (2007) A novel role of phospho-beta-catenin in microtubule regrowth at centrosome. Oncogene, 26, 4357-4371.
24. Huber, A.H. and Weis, W.I. (2001) The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell, 105, 391-402.
25. Huber, A.H., Nelson, W.J., and Weis, W.I. (1997) Threedimensional structure of the armadillo repeat region of beta-catenin. Cell, 90, 871-882.
26. Kennedy, M.W., Cha, S.-W., Tadjuidje, E. et al. (2010). A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus. Developmental Dynamics, 239, 271-283.
27. Kidd, A.R., Miskowski, J.A., Siegfried, K.R. et al. (2005). A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/ MAPK signaling. Cell, 121, 761-772.
28. Korswagen, H.C., Herman, M.A., and Clevers, H.C. (2000) Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. Nature, 406, 527-532.
29. Kramps, T., Peter, O., Brunner, E. et al. (2002). Wnt/ wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell, 109, 47-60.
30. Liu, J., Phillips, B.T., Amaya, M.F. et al. (2008). The C. elegans SYS-1 protein is a bona fide beta-catenin. Developmental Cell, 14, 751-761.
31. Mieszczanek, J., de La Roche, M., and Bienz, M. (2008) A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription. Proceedings of the National Academy of Sciences of the United States of America, 105, 19324-19329.
32. Mizumoto, K. and Sawa, H. (2007) Two betas or not two betas: regulation of asymmetric division by beta-catenin. Trends in Cell Biology, 17, 465-473.
33. Natarajan, L., Witwer, N.E., and Eisenmann, D.M. (2001) The divergent Caenorhabditis elegans betacatenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo. Genetics, 159, 159-172.
34. Nieto, M.A. (2011) The ins and outs of the epithelial to mesenchymal transition in health and disease. Annual Reviews of Cell and Developmental Biology, 27, 347-376.
35. Nüsslein-Volhard, C. and Wieschaus, E. (1980) Mutations affecting segment number and polarity in Drosophila. Nature, 287, 795-801.
36. Oda, H. and Takeichi, M. (2011) Evolution: structural and functional diversity of cadherin at the adherens junction. The Journal of Cell Biology, 193, 1137-1146.
37. Orsulic, S. and Peifer, M. (1996) An in vivo structurefunction study of armadillo, the beta-catenin homolog, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling. The Journal of Cell Biology, 134, 1283-1300.
38. Ozawa, M., Baribault, H., and Kemler, R. (1989) The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. The EMBO Journal, 8, 1711-1717.
39. Peifer, M. and Wieschaus, E. (1990) The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell, 63, 1167-1176.
40. Phillips, B.T. and Kimble, J. (2009) A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway. Developmental Cell, 17, 27-34.
41. Piedra, J., Martinez, D., Castano, J. et al. (2001). Regulation of beta-catenin structure and activity by tyrosine phosphorylation. The Journal of Biological Chemistry, 276, 20436-20443.
42. Piedra, J., Miravet, S., Castaño, J. et al. (2003). p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Molecular and Cellular Biology, 23, 2287-2297.
43. Pokutta, S. and Weis, W.I. (2007) Structure and mechanism of cadherins and catenins in cell-cell contacts. Annual Reviews of Cell and Developmental Biology, 23, 237-261.
44. Pokutta, S., Drees, F., Yamada, S. et al. (2008). Biochemical and structural analysis of alpha-catenin in cell-cell contacts. Biochemical Society Transactions, 36, 141-147.
45. Polakis, P. (2012) Wnt signaling in cancer. Cold Spring Harbor Perspectives in Biology, 4, a008052.
46. Roura, S., Miravet, S., Piedra, J. et al. (1999) Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. The Journal of Biological Chemistry, 274, 36734-36740.
47. Sampietro, J., Dahlberg, C.L., Cho, U.S. et al. (2006). Crystal structure of a beta-catenin/BCL9/Tcf4 complex. Molecular Cell, 24, 293-300.
48. Schneider, S.Q., Finnerty, J.R., and Martindale, M.Q. (2003) Protein evolution: structure-function relationships of the oncogene beta-catenin in the evolution of multicellular animals. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 295, 25-44.
49. Städeli, R. and Basler, K. (2005) Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins. Mechanisms of Development, 122, 1171-1182.
50. Takeichi, M. (2011) Self-organization of animal tissues: cadherin-mediated processes. Developmental Cell, 21, 24-26.
51. Tewari, R., Bailes, E., Bunting, K.A., and Coates, J.C. (2010) Armadillo-repeat protein functions: questions for little creatures. Trends in Cell Biology, 20, 470-481.
52. Valenta, T., Gay, M., Steiner, S. et al. (2011). Probing transcription-specific outputs of β-catenin in vivo. Genes & Development, 25, 2631-2643.
53. van Veelen, W., Le, N.H., Helvensteijn, W. et al. (2011). β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis. Gut, 60, 1204-1212.
54. Xing, Y., Takemaru, K., Liu, J. et al. (2008). Crystal structure of a full-length β-catenin. Structure, 16, 478-487.
55. Zhang, M., Zhang, J., Lin, S.-C., and Meng, A. (2012) β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos. Development, 139, 2009-2019.