Cardiac troponin testing in idiopathic inflammatory myopathies and systemic sclerosis-spectrum disorders: Biomarkers to distinguish between primary cardiac involvement and low-grade skeletal muscle disease activity

Annals of the Rheumatic Diseases

Volumn 74, Issue 5, 2015, Pages 795-798

  Hughes, Michael ^a   Lilleker, James B ^a   Herrick, Ariane L ^a   Chinoy, Hector ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CREATINE KINASE MB; LACTATE DEHYDROGENASE; TROPONIN C; TROPONIN I; TROPONIN T;

ACUTE CORONARY SYNDROME; BINDING AFFINITY; DISEASE ACTIVITY; ENDOCARDITIS; HEART DISEASE; HEART MUSCLE INJURY; HUMAN; MUSCLE REGENERATION; MYOCARDITIS; MYOSITIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; SKELETAL MUSCLE; SYSTEMIC SCLEROSIS; CARDIOMYOPATHIES; COMPLICATION; HEART MUSCLE; METABOLISM;

BIOMARKERS; CARDIOMYOPATHIES; HUMANS; MUSCLE, SKELETAL; MYOCARDIUM; MYOSITIS; SCLERODERMA, SYSTEMIC; TROPONIN I; TROPONIN T;

EID: 84926432141     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-206812     Document Type: Review

References (29)

1. Denbow CE, Lie JT, Tancredi R.G., et al. Cardiac involvement in polymyositis: a clinicopathologic study of 20 autopsied patients. Arthritis Rheum 1979; 22:1088-92.
2. Steen VD, Medsger TA Jr. Severe organ involvement in systemic sclerosis with diffuse scleroderma. Arthritis Rheum 2000; 43:2437-44.
3. Lundberg IE. The heart in dermatomyositis and polymyositis. Rheumatology (Oxford) 2006; 45:iv18-21.
4. Kahan A, Coghlan G, McLaughlin V. Cardiac complications of systemic sclerosis. Rheumatology (Oxford) 2009; 48:iii45-8.
5. Tyndall AJ, Bannert B, Vonk M., et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis 2010; 69:1809-15.
6. Zhang L, Wang GC, Ma L, et al Cardiac involvement in adult polymyositis or dermatomyositis: a systematic review. Clin Cardiol 2012; 35:686-91.
7. Bulkley BH, Ridolfi RL, Salyer W.R., et al. Myocardial lesions of progressive systemic sclerosis: a cause of cardiac dysfunction. Circulation 1976; 53:483-90.
8. Meune C, Vignaux O, Kahan A., et al. Heart involvement in systemic sclerosis: evolving concept and diagnostic methodologies. Arch Cardiovasc Dis 2010; 103:46-52.
9. Lai YT, Dai YS, Yen M.F., et al. Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population-based longitudinal follow-up study. Br J Dermatol 2013; 168:1054-9.
10. Man A, Zhu Y, Zhang Y., et al. The risk of cardiovascular disease in systemic sclerosis: a population-based cohort study. Ann Rheum Dis 2013; 72:1188-93.
11. Bodor GS, Survant L, Voss E.M., et al. Cardiac troponin T composition in normal and regenerating human skeletal muscle. Clin Chem 1997; 43:476-84.
12. Skeik N, Patel DC A review of troponins in ischemic heart disease and other conditions. Int J Angiol 2007; 16:53-8.
13. Clause KC, Tchao J, Powell M.C., et al. Developing cardiac and skeletal muscle share fast-skeletal myosin heavy chain and cardiac troponin-I expression. PLoS One 2012; 7:e40725.
14. Adams JE III, Bodor GS, Dávila-Román VG, et al. Cardiac troponin I: a marker with high specificity for cardiac injury. Circulation 1993; 88:101-6.
15. Anderson PAW, Malouf NN, Oakeley A.E., et al. Troponin T isoform expression in humans: a comparison among normal and failing adult heart, fetal heart and adult and fetal skeletal muscle. Circ Res 1991; 69:1226-33.
16. Erlacher P, Lercher A, Falkensammer J., et al. Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis. Clin Chim Acta 2001; 306:27-33.
17. Hamm CW, Goldmann BU, Heeschen C, et al Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I. N Engl J Med 1997; 337:1648-53.
18. Maynard S, Menown I, Adgey A. Troponin T or troponin I as cardiac markers in ischaemic heart disease. Heart 2000; 83:371-3.
19. Jeremias A, Gibson CM Narrative review: alternative causes for elevated cardiac troponin levels when acute coronary syndromes are excluded. Ann Intern Med 2005; 142:786-91.
20. Agewall S, Giannitsis E, Jernberg T., et al. Troponin elevation in coronary vs. non-coronary disease. Eur Heart J 2011; 32:404-11.
21. Hamilton JS, Sharpe PC Two cases of inflammatory muscle disease presenting with raised serum concentrations of troponin T. J Clin Pathol 2005; 58:1323-4.
22. Schwarzmeier JD, Hamwi A, Preisel M., et al. Positive troponin T without cardiac involvement in inclusion body myositis. Hum Pathol 2005; 36:917-21.
23. Lindberg C, Klintberg L, Oldfors A. Raised troponin T in inclusion body myositis is common and serum levels are persistent over time. Neuromuscul Disord 2006; 16; 495-7.
24. Aggarwal R, Lebiedz-Odrobina D, Sinha A., et al. Serum cardiac troponin T, but not troponin I, is elevated in idiopathic inflammatory myopathies. J Rheumatol 2009; 36:2711-14.
25. Cox FM, Delgado V, Verschuuren J.J., et al. The heart in sporadic inclusion body myositis: a study in 51 patients. J Neurol 2010; 257:447-51.
26. Dinser R, Frerix M, Meier FMP, et al. Endocardial and myocardial involvement in systemic sclerosis-is there a relevant inflammatory component? Joint Bone Spine 2013; 80:320-3.
27. Vasta B, Flower V, Bucciarelli-Ducci C, et al. Abnormal cardiac enzymes in systemic sclerosis: a report of four patients and review of the literature. Clin Rheumatol 2014; 33:435-8.
28. Miller FW, Rider LG, Chung Y.L., et al. Proposed preliminary core set measures for disease outcome assessment in adult and juvenile idiopathic inflammatory myopathies. Rheumatology (Oxford) 2001; 40:1262-73.
29. Kiely PDW, Bruckner FE, Nisbet J.A., et al. Serum skeletal troponin I in inflammatory muscle disease: relation to creatine kinase, CKMB and cardiac troponin I. Ann Rheum Dis 2000; 59:750-1.