Complications of reduced intensity conditioning HSCT for XIAP deficiency (Alloimmune Cytopenias and HLH) successfully managed with donor lymphocyte infusion

Journal of Pediatric Hematology/Oncology

Volumn 37, Issue 3, 2015, Pages e198-e199

  Varghese, Anu S ^a   Lee, Helena ^b   Bonney, Denise ^b   Hughes, Stephen ^a   Wynn, Robert ^b  

^a MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^b ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

reduced intensity regimen; stem cell transplant; T cell chimerism; XIAP

Indexed keywords

GRANULOCYTE ANTIBODY; MYELOABLATIVE AGENT; X LINKED INHIBITOR OF APOPTOSIS; XIAP PROTEIN, HUMAN;

ADOLESCENT; ALLOIMMUNITY; ARTICLE; CASE REPORT; CYTOPENIA; DONOR LYMPHOCYTE INFUSION; ENGRAFTMENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOPHAGOCYTIC SYNDROME; HUMAN; IMMUNE DEFICIENCY; MALE; NEUTROPENIA; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; T LYMPHOCYTE; X LINKED INHIBITOR OF APOPTOSIS PROTEIN DEFICIENCY; ADVERSE EFFECTS; ALLOTRANSPLANTATION; COMPLICATION; CYTOLOGY; DEFICIENCY; GENETIC DISEASES, X-LINKED; GENETICS; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; LYMPHOPROLIFERATIVE DISORDERS; MULTIMODALITY CANCER THERAPY; PANCYTOPENIA; PATHOLOGY; PROGNOSIS;

ADOLESCENT; COMBINED MODALITY THERAPY; GENETIC DISEASES, X-LINKED; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LYMPHOCYTES; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; LYMPHOPROLIFERATIVE DISORDERS; MALE; MYELOABLATIVE AGONISTS; PANCYTOPENIA; PROGNOSIS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84926409309     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0000000000000191     Document Type: Article

References (10)

1. Speckmann C, Lehmberg K, Albert MH,. X-linked inhibitor of apoptosis (XIAP) deficiency: the spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis. Clin Immunol. 2013; 149: 133-141.
2. Marsh RA, Rao K, Satwani P,. Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes. Blood. 2013; 121: 877-883.
3. Cooper N, Rao K, Gilmour K,. Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis. Blood. 2006; 107: 1233-1236.
4. Marsh RA, Vaughn G, Kim M-O,. Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation. Blood. 2010; 116: 5824-5831.
5. Terrell CE, Jordan MB,. Mixed hematopoietic or T-cell chimerism above a minimal threshold restores perforin-dependent immune regulation in perforin-deficient mice. Blood. 2013; 122: 2618-2621.
6. Vitté-Mony I, Korneluk RG, Diaz-Mitoma F,. Role of XIAP protein, a human member of the inhibitor of apoptosis (IAP) protein family, in phytohemagglutinin-induced apoptosis of human T cell lines. Apoptosis. 1997; 2: 501-509.
7. Rigaud S, Fondanèche M-C, Lambert N,. XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome. Nature. 2006; 444: 110-114.
8. Jordan MB, Allen CE, Weitzman S,. How I treat hemophagocytic lymphohistiocytosis. Blood. 2011; 118: 4041-4052.
9. Frey N V, Porter DL,. Graft-versus-host disease after donor leukocyte infusions: presentation and management. Best Pract Res Clin Haematol. 2008; 21: 205-222.
10. Baron F, Maris MB, Storer BE,. High doses of transplanted CD34+ cells are associated with rapid T-cell engraftment and lessened risk of graft rejection, but not more graft-versus-host disease after nonmyeloablative conditioning and unrelated hematopoietic cell transplantation. Leukemia. 2005; 19: 822-828.