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Volumn 11, Issue 1, 2015, Pages 4-6

Developing new oral targeted therapies for RA can be challenging

Author keywords

[No Author keywords available]

Indexed keywords

FOSTAMATINIB; METHOTREXATE; PLACEBO; ANTIRHEUMATIC AGENT;

EID: 84926408937     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2014.187     Document Type: Short Survey
Times cited : (4)

References (10)
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  • 2
    • 77952887713 scopus 로고    scopus 로고
    • The SYK tyrosine kinase: A crucial player in diverse biological functions
    • Mócsai, A., Ruland, J. & Tybulewicz, V. L. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat. Rev. Immunol. 10, 387-402 (2010).
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    • Mócsai, A.1    Ruland, J.2    Tybulewicz, V.L.3
  • 3
    • 84912051613 scopus 로고    scopus 로고
    • Effects of fostamatinib, an oral spleen tyrosine kinase inhibitor, in rheumatoid arthritis patients with an inadequate response to methotrexate: Results from a phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Weinblatt, M. E. et al. Effects of fostamatinib, an oral spleen tyrosine kinase inhibitor, in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Arthritis Rheumatol. http://dx.doi.org/10.1002/art.3885.
    • Arthritis Rheumatol.
    • Weinblatt, M.E.1
  • 4
    • 84919378443 scopus 로고    scopus 로고
    • A phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 2 dosing regimens of fostamatinib in patients with rheumatoid arthritis with an inadequate response to a tumor necrosis factor-α antagonist
    • Genovese, M. C. et al. A phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 2 dosing regimens of fostamatinib in patients with rheumatoid arthritis with an inadequate response to a tumor necrosis factor-α antagonist. J. Rheumatol. http://dx.doi.org/10.3899/jrheum.140238 (2014).
    • (2014) J. Rheumatol.
    • Genovese, M.C.1
  • 5
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    • Treatment of rheumatoid arthritis with a Syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial
    • Weinblatt, M. E. et al. Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial. Arthritis Rheum. 58, 3309-3318 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 3309-3318
    • Weinblatt, M.E.1
  • 6
    • 84875845688 scopus 로고    scopus 로고
    • Effects of fostamatinib (R788), an oral spleen tyrosine kinase inhibitor, on health-related quality of life in patients with active rheumatoid arthritis: Analyses of patient-reported outcomes from a randomized, doubleblind, placebo-controlled trial
    • Weinblatt, M. E. et al. Effects of fostamatinib (R788), an oral spleen tyrosine kinase inhibitor, on health-related quality of life in patients with active rheumatoid arthritis: analyses of patient-reported outcomes from a randomized, doubleblind, placebo-controlled trial. J. Rheumatol. 40, 369-378 (2013).
    • (2013) J. Rheumatol. , vol.40 , pp. 369-378
    • Weinblatt, M.E.1
  • 7
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    • Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
    • Fleischmann, R. et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N. Engl. J. Med. 367, 495-507 (2012).
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    • Fleischmann, R.1
  • 8
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    • Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
    • Van Vollenhoven, R. et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N. Engl. J. Med. 367, 508-519 (2012).
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    • Van Vollenhoven, R.1
  • 9
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    • Burmester, G. R. et al. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet 381, 451-460 (2013).
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    • Genovese, M. C. et al. 24-week results of a blinded phase 2b dose-ranging study of baricitinib, an oral Janus kinase 1/Januse kinase 2 inhibitor, in combination with traditional disease modifying antirheumatic drugs in patients with rheumatoid arthritis [abstract 2487]. Arthritis Rheum. 64 (Suppl.), S1049-S1050 (2012).
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    • Genovese, M.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.