Simultaneous screening for 45 poisonous alkaloids in blood by LC-MS/MS

Journal of Forensic Medicine

Volumn 31, Issue 1, 2015, Pages 28-33

  Zhai, Jin Xiao ^a,b   Shen, Min ^b   Liu, Wei ^b  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Alkaloids; Blood; Chromatography, liquid; Forensic toxicology; Tandem mass spectrometry

Indexed keywords

ALKALOID;

BLOOD; CHEMISTRY; FORENSIC MEDICINE; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; PROCEDURES; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

ALKALOIDS; CHROMATOGRAPHY, LIQUID; FORENSIC MEDICINE; HUMANS; LIQUID-LIQUID EXTRACTION; MASS SPECTROMETRY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84926368402     PISSN: 10045619     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1004-5619.2015.01.007     Document Type: Article

References (18)

1. Talaty N, Takáts Z, Cooks RG. Rapid in situ detection of alkaloids in plant tissue under ambient conditions using desorption electrospray ionization [J]. Analyst, 2005, 130(12): 1624-1633.
2. Spiller GA. Caffeine[M]. Boca Raton: CRC Press Inc, 1997.
3. Beyer J, Peters FT, Kraemer T, et al. Detection and validated quantification of toxic alkaloids in human blood plasma-comparison of LC-APCI-MS with LC-ESI-MS/MS[J]. J Mass Spectrom, 2007, 42 (5): 621-633.
4. Maurer HH. Demands on scientific studies in clinical toxicology [J]. Forensic Sci Int, 2007, 165(2-3): 194-198.
5. Jin M, Zhang FR, Cai XY, et al. Determination of atropine in plasma and urine by HPLC[J]. Chinese Journal of Hospital Pharmacy, 2005, 25(5): 426-428.
6. Namera A, Yashiki M, Hirose Y, et al. Quantitative analysis of tropane alkaloids in biological materials by gas chromatography-mass spectrometry[J]. Forensic Sci Int, 2002, 130(1): 34-43.
7. Ito K, Ohyama Y, Konishi Y, et al. Method for the simultaneous determination of Aconitum alkaloids and their hydrolysis products by gas chromatography-mass spectrometry in human serum[J]. Planta Med, 1997, 63(1): 75-79.
8. Oertel R, Richter K, Ebert U, et al. Determination of scopolamine in human serum by gas chromatography-ion trap tandem mass spectrometry [J]. J Chromatogr B Biomed Appl, 1996, 682(2): 259-264.
9. Jacob P 3rd, Wu S, Yu L, et al. Simultaneous determination of mecamylamine, nicotine, and cotinine in plasma by gas chromatography-mass spectrometry [J]. J Pharm Biomed Anal, 2000, 23(4): 653-661.
10. Cognard E, Staub C. Determination of nicotine and its major metabolite cotinine in plasma or serum by gas chromatography-mass spectrometry using ion-trap detection[J]. Clin Chem Lab Med, 2003, 41 (12): 1599-1607.
11. Steenkamp PA, Harding NM, van Heerden FR, et al. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry [J]. Forensic Sci Int, 2004, 145(1): 31-39.
12. Oertel R, Richter K, Ebert U, et al. Determination of scopolamine in human serum and microdialysis samples by liquid chromatography-tandem mass spectrometry [J]. J Chromatogr B Biomed Sci Appl, 2001, 750(1): 121-128.
13. Jones GR, Singer PP, Bannach B. Application of LC-MS analysis to a colchicine fatality [J]. J Anal Toxicol, 2002, 26(6): 365-369.
14. Chèze M, Lenoan A, Deveaux M, et al. Determination of ibogaine and noribogaine in biological fluids and hair by LC-MS/MS after Tabernanthe iboga abuse Iboga alkaloids distribution in a drowning death case [J]. Forensic Sci Int, 2008, 176(1): 58-66.
15. Peters FT, Drummer OH, Musshoff F. Validation of new methods[J]. Forensic Sci Int, 2007, 165(2-3): 216-224.
16. Hesse M. Alkaloids: nature's curse or blessing? [M]. Weinheim: Wiley-VCH, 2002: 313-316.
17. Gergov M, Ojanperä I, Vuori E. Simultaneous screening for 238 drugs in blood by liquid chromatography-ion spray tandem mass spectrometry with multiple-reaction monitoring [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2003, 795(1): 41-53.
18. Liu G, Dong J, Wang H, et al. Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry [J]. J Pharm Biomed Anal, 2011, 54(5): 1065-1072.