The epidemiology of cancers in human immunodeficiency virus infection and after organ transplantation

Seminars in Oncology

Volumn 42, Issue 2, 2015, Pages 247-257

  Grulich, Andrew E ^a   Vajdic, Claire M ^b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; CANCER EPIDEMIOLOGY; CANCER RISK; COLORECTAL CANCER; DISEASE SEVERITY; EPSTEIN BARR VIRUS; ESOPHAGUS CANCER; GRAFT RECIPIENT; HELICOBACTER PYLORI; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HODGKIN DISEASE; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IMMUNOSUPPRESSIVE TREATMENT; KAPOSI SARCOMA; LARYNX CANCER; LIP CANCER; LUNG CANCER; MELANOMA; MERKEL CELL POLYOMAVIRUS; NASOPHARYNX CANCER; NEOPLASM; NON MELANOMA SKIN CANCER; NONHODGKIN LYMPHOMA; ORGAN TRANSPLANTATION; PLASMACYTOMA; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; WART VIRUS; ADVERSE EFFECTS; COMPLICATION; NEOPLASMS;

HIV INFECTIONS; HUMANS; NEOPLASMS; ORGAN TRANSPLANTATION;

EID: 84926362916     PISSN: 00937754     EISSN: 15328708     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2014.12.029     Document Type: Review

References (105)

1. R. Hoover, and J.F. Fraumeni Jr Risk of cancer in renal-transplant recipients Lancet 2 7820 1973 55 57
2. I. Penn Kaposi's sarcoma in transplant recipients Transplantation 64 5 1997 669 673
3. J.J. Goedert, T.R. Cote, P. Virgo, S.M. Scoppa, D.W. Kingma, M.H. Gail, E.S. Jaffe, and R.J. Biggar Spectrum of AIDS-associated malignant disorders Lancet 351 9119 1998 1833 1839
4. S. Franceschi, L. Dal Maso, and S. Arniani Risk of cancer other than Kaposi's sarcoma and non-Hodgkin's lymphoma in persons with AIDS in Italy. Cancer and AIDS Registry Linkage Study Br J Cancer 78 7 1998 966 970
5. A.E. Grulich, Y. Li, A. McDonald, P.K. Correll, M.G. Law, and J.M. Kaldor Rates of non-AIDS-defining cancers in people with HIV infection before and after AIDS diagnosis Aids 16 8 2002 1155 1161
6. S.A. Birkeland, H. Lokkegaard, and H.H. Storm Cancer risk in patients on dialysis and after renal transplantation Lancet 355 9218 2000 1886 1887
7. L. Kyllonen, K. Salmela, and E. Pukkala Cancer incidence in a kidney-transplanted population Transpl Int 13 Suppl 1 2000 S394 S398
8. J. Adami, H. Gabel, and B. Lindelof Cancer risk following organ transplantation: a nationwide cohort study in Sweden Br J Cancer 89 7 2003 1221 1227
9. C.M. Vajdic, S.P. McDonald, and M.R. McCredie Cancer incidence before and after kidney transplantation JAMA 296 23 2006 2823 2831
10. P.J. Villeneuve, D.E. Schaubel, S.S. Fenton, F.A. Shepherd, Y. Jiang, and Y. Mao Cancer incidence among canadian kidney transplant recipients Am J Transplant 7 4 2007 941 948
11. Y. Jiang, P.J. Villeneuve, S.S. Fenton, D.E. Schaubel, L. Lilly, and Y. Mao Liver transplantation and subsequent risk of cancer: findings from a Canadian cohort study Liver Transpl 14 11 2008 1588 1597
12. Y. Jiang, P.J. Villeneuve, A. Wielgosz, D.E. Schaubel, S.S. Fenton, and Y. Mao The incidence of cancer in a population-based cohort of Canadian heart transplant recipients Am J Transplant 10 3 2010 637 645
13. E.A. Engels, R.M. Pfeiffer, and J.F. Fraumeni Jr Spectrum of cancer risk among US solid organ transplant recipients JAMA 306 17 2011 1891 1901
14. A.E. Grulich, M.T. van Leeuwen, MO Falster, and CM Vajdic Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 370 9581 2007 59 67
15. International Agency for Research on Cancer working group on the evaluation of carcinogenic risk to humans. Biological Agents, Volume 100B: A review of human carcinogens IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 2012 IARC Lyon, France
16. V. Beral, and R. Newton Overview of the epidemiology of immunodeficiency-associated cancers J Natl Cancer Inst Monogr 23 1998 1 6
17. M.J. Silverberg, C. Chao, and W.A. Leyden HIV infection, immunodeficiency, viral replication, and the risk of cancer Cancer Epidemiol Biomarkers Prev 20 12 2011 2551 2559
18. M. Guiguet, F. Boue, J. Cadranel, J.M. Lang, E. Rosenthal, and D. Costagliola Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study Lancet Oncol 10 12 2009 1152 1159
19. S. Franceschi, L.D. Maso, and M. Rickenbach Kaposi sarcoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy Br J Cancer 99 5 2008 800 804
20. E.L. Yanik, S. Napravnik, and S.R. Cole Incidence and timing of cancer in HIV-infected individuals following initiation of combination antiretroviral therapy Clin Infect Dis 57 5 2013 756 764
21. M.T. van Leeuwen, C.M. Vajdic, and M.G. Middleton Continuing declines in some but not all HIV-associated cancers in Australia after widespread use of antiretroviral therapy Aids 23 16 2009 2183 2190
22. H.A. Robbins, M.S. Shiels, R.M. Pfeiffer, and E.A. Engels Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States AIDS 28 6 2014 881 890
23. F.J. Moloney, H. Comber, P. O'Lorcain, P. O'Kelly, P.J. Conlon, and G.M. Murphy A population-based study of skin cancer incidence and prevalence in renal transplant recipients Br J Dermatol 154 3 2006 498 504
24. E. Lanoy, D. Costagliola, and E.A. Engels Skin cancers associated with HIV infection and solid-organ transplantation among elderly adults Int J Cancer 126 7 2010 1724 1731
25. B. Krynitz, G. Edgren, and B. Lindelof Risk of skin cancer and other malignancies in kidney, liver, heart and lung transplant recipients 1970 to 2008 - a Swedish population-based study Int J Cancer 132 6 2013 1429 1438
26. R. Na, A.E. Grulich, N.S. Meagher, G.W. McCaughan, A.M. Keogh, and C.M. Vajdic Comparison of de novo cancer incidence in Australian liver, heart and lung transplant recipients Am J Transplant 13 1 2013 174 183
27. D. Collett, L. Mumford, N.R. Banner, J. Neuberger, and C. Watson Comparison of the incidence of malignancy in recipients of different types of organ: a UK Registry audit Am J Transplant 10 8 2010 1889 1896
28. C. Lebbe, C. Legendre, and C. Frances Kaposi sarcoma in transplantation Transplant Rev (Orlando) 22 4 2008 252 261
29. D. Serraino, C. Angeletti, and M.P. Carrieri Kaposi's sarcoma in transplant and HIV-infected patients: an epidemiologic study in Italy and France Transplantation 80 12 2005 1699 1704
30. G. Stallone, A. Schena, and B. Infante Sirolimus for Kaposi's sarcoma in renal-transplant recipients N Engl J Med 352 13 2005 1317 1323
31. G. Tessari, L. Naldi, and L. Boschiero Incidence and clinical predictors of Kaposi's sarcoma among 1721 Italian solid organ transplant recipients: a multicenter study Eur J Dermatol 16 5 2006 553 557
32. S.M. Mbulaiteye, and E.A. Engels Kaposi's sarcoma risk among transplant recipients in the United States (1993-2003) Int J Cancer 119 11 2006 2685 2691
33. E.J. Ariza-Heredia, and R.R. Razonable Human herpes virus 8 in solid organ transplantation Transplantation 92 8 2011 837 844
34. M.C. Robotin, M.G. Law, and S. Milliken Clinical features and predictors of survival of AIDS-related non-Hodgkin's lymphoma in a population-based case series in Sydney, Australia HIV Med 5 5 2004 377 384
35. C.M. Vajdic, M.T. van Leeuwen, and J.J. Turner No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency Int J Cancer 127 11 2010 2732 2735
36. J. Polesel, G.M. Clifford, and M. Rickenbach Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy Aids 22 2 2008 301 306
37. S. Preston-Martin, L.M. Kirstein, and J.M. Pogoda Use of mammographic screening by HIV-infected women in the Women's Interagency HIV Study (WIHS) Prev Med 34 3 2002 386 392
38. Collaboration of Observational HIVERESG, J. Bohlius, and K. Schmidlin Incidence and risk factors of HIV-related non-Hodgkin's lymphoma in the era of combination antiretroviral therapy: a European multicohort study Antivir Ther 14 8 2009 1065 1074
39. A.E. Grulich, X. Wan, and M.G. Law B-cell stimulation and prolonged immune deficiency are risk factors for non-Hodgkin's lymphoma in people with AIDS Aids 14 2 2000 133 140
40. A.J. De Roos, D.K. Mirick, and K.L. Edlefsen Markers of B-cell activation in relation to risk of non-Hodgkin lymphoma Cancer Res 72 18 2012 4733 4743
41. E.A. Engels, R.M. Pfeiffer, O. Landgren, and R.D. Moore Immunologic and virologic predictors of AIDS-related non-Hodgkin lymphoma in the highly active antiretroviral therapy era J Acquir Immune Defic Syndr 54 1 2010 78 84
42. M.T. van Leeuwen, A.E. Grulich, and A.C. Webster Immunosuppression and other risk factors for early and late non-Hodgkin lymphoma after kidney transplantation Blood 114 3 2009 630 637
43. S.C. Quinlan, R.M. Pfeiffer, L.M. Morton, and E.A. Engels Risk factors for early-onset and late-onset post-transplant lymphoproliferative disorder in kidney recipients in the United States Am J Hematol 86 2 2011 206 209
44. T.M. Gibson, E.A. Engels, C.A. Clarke, C.F. Lynch, D.D. Weisenburger, and L.M. Morton Risk of diffuse large B-cell lymphoma after solid organ transplantation in the United States Am J Hematol 89 7 2014 714 720
45. International Agency for Research on Cancer working group on the evaluation of carcinogenic risk to humans. Pharmaceuticals, Volume 100A: A review of human carcinogens IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 2012 IARC Lyon, France
46. P. Fernberg, G. Edgren, and J. Adami Time trends in risk and risk determinants of non-Hodgkin lymphoma in solid organ transplant recipients Am J Transplant 11 11 2011 2472 2482
47. T.E. Starzl, M.A. Nalesnik, and K.A. Porter Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy Lancet 1 8377 1984 583 587
48. J. Reekie, C. Kosa, and F. Engsig Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies Cancer 116 2010 5306 5315
49. M.A. Kowalkowski, M.A. Mims, R.S. Day, X.L. Du, W. Chan, and E.Y. Chiao Longer duration of combination antiretroviral therapy reduces the risk of Hodgkin lymphoma: A cohort study of HIV-infected male veterans Cancer Epidemiol 38 2014 386 392
50. C.A. Clarke, L.M. Morton, and C. Lynch Risk of lymphoma subtypes after solid organ transplantation in the United States Br J Cancer 109 1 2013 280 288
51. S.C. Quinlan, O. Landgren, L.M. Morton, and E.A. Engels Hodgkin lymphoma among US solid organ transplant recipients Transplantation 90 9 2010 1011 1015
52. F.M. Shebl, K. Bhatia, and E.A. Engels Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States Int J Cancer 126 10 2010 2503 2508
53. Y.X. Zhang, X.E. Gui, Y.H. Zhong, Y.P. Rong, and Y.J. Yan Cancer in cohort of HIV-infected population: prevalence and clinical characteristics J Cancer Res Clin Oncol 137 4 2011 609 614
54. C.Y. Cheung, M.F. Lam, and K.H. Chu Malignancies after kidney transplantation: Hong Kong renal registry Am J Transplant 12 11 2012 3039 3046
55. L. Dal Maso, S. Franceschi, and J. Polesel Risk of cancer in persons with AIDS in Italy, 1985-1998 Br J Cancer 89 1 2003 94 100
56. A.G. Abraham, G. D'Souza, and Y. Jing Invasive cervical cancer risk among HIV-infected women: a North American multicohort collaboration prospective study J Acquir Immune Defic Syndr 62 4 2013 405 413
57. S.A. Denslow, A.F. Rositch, C. Firnhaber, J. Ting, and J.S. Smith Incidence and progression of cervical lesions in women with HIV: a systematic global review Int J STD AIDS 25 3 2014 163 177
58. S. Blitz, J. Baxter, and J. Raboud Evaluation of HIV and highly active antiretroviral therapy on the natural history of human papillomavirus infection and cervical cytopathologic findings in HIV-positive and high-risk HIV-negative women J Infect Dis 208 3 2013 454 462
59. A.K. Chaturvedi, M.M. Madeleine, R.J. Biggar, and E.A. Engels Risk of human papillomavirus-associated cancers among persons with AIDS J Natl Cancer Inst 101 16 2009 1120 1130
60. M.J. Silverberg, B. Lau, and A.C. Justice Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America Clin Infect Dis 54 7 2012 1026 1034
61. E.Y. Chiao, C.M. Hartman, H.B. El-Serag, and T.P. Giordano The impact of HIV viral control on the incidence of HIV-associated anal cancer J Acquir Immune Defic Syndr 63 5 2013 631 638
62. N.F. Crum-Cianflone, K.H. Hullsiek, and V.C. Marconi Anal cancers among HIV-infected persons: HAART is not slowing rising incidence AIDS 24 4 2010 535 543
63. A.E. Grulich, R. Hillman, J.M. Brotherton, and C.K. Fairley Time for a strategic research response to anal cancer Sex Health 9 6 2012 628 631
64. Madeleine, M.M. Finch, J.L. Lynch, C.F. Goodman, and M.T. Engels EA. HPV-related cancers after solid organ transplantation in the United States Am J Transplant 13 12 2013 3202 3209
65. M.T. van Leeuwen, A.C. Webster, and M.R. McCredie Effect of reduced immunosuppression after kidney transplant failure on risk of cancer: population based retrospective cohort study BMJ 340 2010 c570
66. V.V. Sahasrabuddhe, M.S. Shiels, K.A. McGlynn, and E.A. Engels The risk of hepatocellular carcinoma among individuals with acquired immunodeficiency syndrome in the United States Cancer 118 24 2012 6226 6233
67. G.M. Clifford, M. Rickenbach, and J. Polesel Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma AIDS 22 16 2008 2135 2141
68. D. Serraino, P. Piselli, and G. Busnach Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe Eur J Cancer 43 14 2007 2117 2123
69. C.M. Vajdic, G.W. McCaughan, and A.E. Grulich Cancer risk after organ transplantation JAMA 307 7 2012 663
70. J. Koshiol, K. Pawlish, M.T. Goodman, K.A. McGlynn, and E.A. Engels Risk of Hepatobiliary Cancer After Solid Organ Transplant in the United States Clin Gastroenterol Hepatol 12 2013 1541 1549
71. L.M. Morton, T.M. Gibson, C.A. Clarke, C.F. Lynch, D.D. Weisenburger, and E.A. Engels Hepatitis B or C virus infection and risk of non-Hodgkin lymphoma among solid organ transplant recipients Haematologica 99 5 2014 70 73
72. L. Waters, J. Stebbing, S. Mandalia, A.M. Young, M. Nelson, B. Gazzard, and M. Bower Hepatitis C infection is not associated with systemic HIV-associated non-Hodgkin's lymphoma: a cohort study Int J Cancer 116 1 2005 161 163
73. S. Franceschi, J. Polesel, and M. Rickenbach Hepatitis C virus and non-Hodgkin's lymphoma: findings from the Swiss HIV cohort study Br J Cancer 95 11 2006 1598 1602
74. F. Bonnet, E. Balestre, and R. Thiebaut Factors associated with the occurrence of AIDS-related non-Hodgkin lymphoma in the era of highly active antiretroviral therapy: Aquitaine Cohort, France Clin Infect Dis 42 3 2006 411 417
75. E.C. Persson, M.S. Shiels, S.M. Dawsey, K. Bhatia, L.A. Anderson, and E.A. Engels Increased risk of stomach and esophageal malignancies in people with AIDS Gastroenterology 143 4 2012 943 950
76. H. Feng, M. Shuda, Y. Chang, and P.S. Moore Clonal integration of a polyomavirus in human Merkel cell carcinoma Science 319 5866 2008 1096 1100
77. International Agency for Research on Cancer working group on the evaluation of carcinogenic risk to humans Malaria and some Polyomaviruses (SV40, BK, JC, and Merkel cell viruses) Volume 104 2013 IARC Lyon, France
78. E.A. Engels, M. Frisch, J.J. Goedert, R.J. Biggar, and R.W. Miller Merkel cell carcinoma and HIV infection Lancet 359 9305 2002 497 498
79. V. Koljonen, H. Kukko, and E. Tukiainen Incidence of Merkel cell carcinoma in renal transplant recipients Nephrol Dial Transplant 24 10 2009 3231 3235
80. M.M. Friedlaender, D. Rubinger, E. Rosenbaum, G. Amir, and E. Siguencia Temporary regression of Merkel cell carcinoma metastases after cessation of cyclosporine Transplantation 73 11 2002 1849 1850
81. K.G. Paulson, J.G. Iyer, and A. Blom Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage J Invest Dermatol 133 3 2013 642 646
82. G.M. Clifford, M. Lise, and S. Franceschi Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection Br J Cancer 106 3 2012 447 452
83. F.M. Shebl, E.A. Engels, J.J. Goedert, and A.K. Chaturvedi Pulmonary infections and risk of lung cancer among persons with AIDS J Acquir Immune Defic Syndr 55 3 2010 375 379
84. M. Guech-Ongey, E.A. Engels, J.J. Goedert, R.J. Biggar, and S.M. Mbulaiteye Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States Int J Cancer 122 11 2008 2590 2593
85. C.M. Vajdic, M.T. van Leeuwen, and S.P. McDonald Increased incidence of squamous cell carcinoma of eye after kidney transplantation J Natl Cancer Inst 99 17 2007 1340 1342
86. M.J. Silverberg, W. Leyden, E.M. Warton, C.P. Quesenberry Jr., E.A. Engels, and M.M. Asgari HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer J Natl Cancer Inst 105 5 2013 350 360
87. C.M. Perrett, S.L. Walker, and P. O'Donovan Azathioprine treatment photosensitizes human skin to ultraviolet A radiation Br J Dermatol 159 1 2008 198 204
88. A. Ingvar, K.E. Smedby, and B. Lindelof Immunosuppressive treatment after solid organ transplantation and risk of post-transplant cutaneous squamous cell carcinoma Nephrol Dial Transplant 25 8 2010 2764 2771
89. P. Jensen, S. Hansen, and B. Moller Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens J Am Acad Dermatol 40 2 Pt 1 1999 177 186
90. F.O. Zwald, and M. Brown Skin cancer in solid organ transplant recipients: advances in therapy and management: part I. Epidemiology of skin cancer in solid organ transplant recipients J Am Acad Dermatol 65 2 2011 253 261
91. R.P. Carroll, H.M. Ramsay, A.A. Fryer, C.M. Hawley, D.L. Nicol, and P.N. Harden Incidence and prediction of nonmelanoma skin cancer post-renal transplantation: a prospective study in Queensland, Australia Am J Kidney Dis 41 3 2003 676 683
92. H.M. Ramsay, A.A. Fryer, C.M. Hawley, A.G. Smith, D.L. Nicol, and P.N. Harden Factors associated with nonmelanoma skin cancer following renal transplantation in Queensland, Australia J Am Acad Dermatol 49 3 2003 397 406
93. R. Gogia, M. Binstock, R. Hirose, W.J. Boscardin, M.M. Chren, and S.T. Arron Fitzpatrick skin phototype is an independent predictor of squamous cell carcinoma risk after solid organ transplantation J Am Acad Dermatol 68 4 2013 585 591
94. M.J. Veness, D.I. Quinn, and C.S. Ong Aggressive cutaneous malignancies following cardiothoracic transplantation: the Australian experience Cancer 85 8 1999 1758 1764
95. J. Kanitakis, L. Alhaj-Ibrahim, S. Euvrard, and A. Claudy Basal cell carcinomas developing in solid organ transplant recipients: clinicopathologic study of 176 cases Arch Dermatol 139 9 2003 1133 1137
96. C.A. Harwood, C.M. Proby, J.M. McGregor, M.T. Sheaff, I.M. Leigh, and R. Cerio Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series J Am Acad Dermatol 54 2 2006 290 300
97. C.M. Vajdic, M.T. van Leeuwen, and A.C. Webster Cutaneous melanoma is related to immune suppression in kidney transplant recipients Cancer Epidemiol Biomarkers Prev 18 8 2009 2297 2303
98. C.M. Vajdic, A.H. Chong, and P.J. Kelly Survival after cutaneous melanoma in kidney transplant recipients: a population-based matched cohort study Am J Transplant 14 6 2014 1368 1375
99. M.T. van Leeuwen, A.E. Grulich, and S.P. McDonald Immunosuppression and other risk factors for lip cancer after kidney transplantation Cancer Epidemiol Biomarkers Prev 18 2 2009 561 569
100. S. Moyano, J. Ordi, and M. Caballero Laryngeal squamous cell carcinoma in HIV-positive patients: lack of association with human papillomavirus infection HIV Med 10 10 2009 634 639
101. M.S. Shiels, and E.A. Engels Increased risk of histologically defined cancer subtypes in human immunodeficiency virus-infected individuals: clues for possible immunosuppression-related or infectious etiology Cancer 118 19 2012 4869 4876
102. E.A. Engels, C.A. Clarke, and R.M. Pfeiffer Plasma cell neoplasms in US solid organ transplant recipients Am J Transplant 13 6 2013 1523 1532
103. J.J. Goedert, C. Schairer, and T.S. McNeel Risk of breast, ovary, and uterine corpus cancers among 85,268 women with AIDS Br J Cancer 95 5 2006 642 648
104. M.S. Shiels, J.J. Goedert, R.D. Moore, E.A. Platz, and E.A. Engels Reduced risk of prostate cancer in U.S. Men with AIDS Cancer Epidemiol Biomarkers Prev 19 11 2010 2910 2915
105. K.K. Jorgensen, L. Lindstrom, and M. Cvancarova Immunosuppression after liver transplantation for primary sclerosing cholangitis influences activity of inflammatory bowel disease Clin Gastroenterol Hepatol 11 5 2013 517 523