-
1
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couedic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144-1148.
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
-
2
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7(4):387-397.
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
-
3
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365(9464):1054-1061.
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
-
4
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352 (17):1779-1790.
-
(2005)
N Engl J Med
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
-
5
-
-
84890372480
-
Somatic mutations of calreticulin in myeloproliferative neoplasms
-
Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369 (25):2379-2390.
-
(2013)
N Engl J Med
, vol.369
, Issue.25
, pp. 2379-2390
-
-
Klampfl, T.1
Gisslinger, H.2
Harutyunyan, A.S.3
-
6
-
-
84890328032
-
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
-
Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369(25):2391-2405.
-
(2013)
N Engl J Med
, vol.369
, Issue.25
, pp. 2391-2405
-
-
Nangalia, J.1
Massie, C.E.2
Baxter, E.J.3
-
7
-
-
84897568260
-
Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia
-
Rotunno G, Mannarelli C, Guglielmelli P, et al. Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia. Blood. 2014;123(10):1552-1555.
-
(2014)
Blood
, vol.123
, Issue.10
, pp. 1552-1555
-
-
Rotunno, G.1
Mannarelli, C.2
Guglielmelli, P.3
-
8
-
-
84904056081
-
CALR and ASXL1 mutationsbased molecular prognostication in primary myelofibrosis: An international study of 570 patients
-
Tefferi A, Guglielmelli P, Lasho TL, et al. CALR and ASXL1 mutationsbased molecular prognostication in primary myelofibrosis: an international study of 570 patients. Leukemia. 2014;28(7):1494-500.
-
(2014)
Leukemia
, vol.28
, Issue.7
, pp. 1494-1500
-
-
Tefferi, A.1
Guglielmelli, P.2
Lasho, T.L.3
-
9
-
-
84922693801
-
Effect of mutation order on myeloproliferative neoplasms
-
Ortmann CA, Kent DG, Nangalia J, et al. Effect of mutation order on myeloproliferative neoplasms. N Engl J Med. 2015;372(7):601-612.
-
(2015)
N Engl J Med
, vol.372
, Issue.7
, pp. 601-612
-
-
Ortmann, C.A.1
Kent, D.G.2
Nangalia, J.3
-
10
-
-
77956696835
-
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
-
Verstovsek S, Kantarjian H, Mesa RA, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med. 2010;363(12):1117-1127.
-
(2010)
N Engl J Med
, vol.363
, Issue.12
, pp. 1117-1127
-
-
Verstovsek, S.1
Kantarjian, H.2
Mesa, R.A.3
-
11
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366(9):799-807.
-
(2012)
N Engl J Med
, vol.366
, Issue.9
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
-
12
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
Harrison C, Kiladjian JJ, Al-Ali HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366(9):787-798.
-
(2012)
N Engl J Med
, vol.366
, Issue.9
, pp. 787-798
-
-
Harrison, C.1
Kiladjian, J.J.2
Al-Ali, H.K.3
-
13
-
-
84926337489
-
Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: Results of a median 3-year follow-up of COMFORT-I
-
Verstovsek S, Mesa RA, Gotlib J, et al. Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I. Haematologica. 2015;(4):479-488.
-
(2015)
Haematologica
, Issue.4
, pp. 479-488
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
-
14
-
-
84891303523
-
Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
-
Cervantes F, Vannucchi AM, Kiladjian JJ, et al. Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis. Blood. 2013;122(25):4047-4053.
-
(2013)
Blood
, vol.122
, Issue.25
, pp. 4047-4053
-
-
Cervantes, F.1
Vannucchi, A.M.2
Kiladjian, J.J.3
-
15
-
-
84899056972
-
Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study
-
Guglielmelli P, Biamonte F, Rotunno G, et al. Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study. Blood. 2014;123(14):2157-2160.
-
(2014)
Blood
, vol.123
, Issue.14
, pp. 2157-2160
-
-
Guglielmelli, P.1
Biamonte, F.2
Rotunno, G.3
-
16
-
-
84896997474
-
A pooled overall survival analysis of the COMFORT studies: 2 randomized phase 3 trials of ruxolitinib for the treatment of myelofibrosis
-
abstract 2820
-
Hagop K, Kiladjian J-J, Gotlib J, et al. A pooled overall survival analysis of the COMFORT studies: 2 randomized phase 3 trials of ruxolitinib for the treatment of myelofibrosis. Blood. 2013;122(21):abstract 2820.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
Hagop, K.1
Kiladjian, J.-J.2
Gotlib, J.3
-
17
-
-
84889852354
-
Resolution of bone marrow fibrosis in a patient receiving JAK1/JAK2 inhibitor treatment with ruxolitinib
-
Wilkins BS, Radia D, Woodley C, Farhi SE, Keohane C, Harrison CN. Resolution of bone marrow fibrosis in a patient receiving JAK1/JAK2 inhibitor treatment with ruxolitinib. Haematologica. 2013;98(12):1872-1876.
-
(2013)
Haematologica
, vol.98
, Issue.12
, pp. 1872-1876
-
-
Wilkins, B.S.1
Radia, D.2
Woodley, C.3
Farhi, S.E.4
Keohane, C.5
Harrison, C.N.6
-
18
-
-
84926386428
-
Complete clinical, histopathologic and molecular remission of primary myelofibrosis with long-term treatment with the JAK1/2 inhibitor ruxolitinib
-
San Fransisco, CA, USA, Abstract 1836
-
Al-Ali HK, Hubert K, Lange T, et al. Complete clinical, histopathologic and molecular remission of primary myelofibrosis with long-term treatment with the JAK1/2 inhibitor ruxolitinib. 56th ASH Annual Meeting. San Fransisco, CA, USA. 6-9, 2014. Abstract 1836.
-
(2014)
56Th ASH Annual Meeting
, pp. 6-9
-
-
Al-Ali, H.K.1
Hubert, K.2
Lange, T.3
-
19
-
-
84902686517
-
Safety evaluation of ruxolitinib for treating myelofibrosis
-
Galli S, McLornan D, Harrison C. Safety evaluation of ruxolitinib for treating myelofibrosis. Expert Opin Drug Saf. 2014;13(7):967-976.
-
(2014)
Expert Opin Drug Saf
, vol.13
, Issue.7
, pp. 967-976
-
-
Galli, S.1
McLornan, D.2
Harrison, C.3
-
20
-
-
84872424841
-
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
-
Hasselbalch HC. Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development? Leukemia Res. 2013;37(2):214-220.
-
(2013)
Leukemia Res
, vol.37
, Issue.2
, pp. 214-220
-
-
Hasselbalch, H.C.1
-
21
-
-
84893773351
-
Rapid and long-lasting decrease of T-regulatory cells in patients with myelofibrosis treated with ruxolitinib
-
Massa M, Rosti V, Campanelli R, Fois G, Barosi G. Rapid and long-lasting decrease of T-regulatory cells in patients with myelofibrosis treated with ruxolitinib. Leukemia. 2014;28(2):449-451.
-
(2014)
Leukemia
, vol.28
, Issue.2
, pp. 449-451
-
-
Massa, M.1
Rosti, V.2
Campanelli, R.3
Fois, G.4
Barosi, G.5
-
22
-
-
84902657461
-
The JAK1/JAK2 inhibitor ruxolitinib substantially affects NK cell biology
-
Rudolph J, Cornez I, Brossart P, Wolf D. The JAK1/JAK2 inhibitor ruxolitinib substantially affects NK cell biology. Blood. 2013;122(21):16.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
Rudolph, J.1
Cornez, I.2
Brossart, P.3
Wolf, D.4
-
23
-
-
84902677082
-
The Pan-JAK inhibitor ruxolitinib impairs T-cell activation, cytokine production and proliferation in vivo and in vitro
-
Wolschke C, Alchalby H, Ayuk F, et al. The Pan-JAK inhibitor ruxolitinib impairs T-cell activation, cytokine production and proliferation in vivo and in vitro. Blood. 2013;122(21):2001.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
Wolschke, C.1
Alchalby, H.2
Ayuk, F.3
-
24
-
-
84924763699
-
Decrease of T regulatory cells in patients with myelofibrosis receiving ruxolitinib
-
Campanelli R, Fois G, Poletto V, et al. Decrease of T regulatory cells in patients with myelofibrosis receiving ruxolitinib. Blood. 2013;122(21):4057.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
Campanelli, R.1
Fois, G.2
Poletto, V.3
-
25
-
-
84902665938
-
JAK inhibition reduces CD25 high CD27+ FOXp3+ T regulatory cells and causes a silencing of T effector cells in patients with myeloproliferative neoplasms whilst promoting a TH17 phenotype
-
Kordasti SY, Seidl T, Abellan PP, et al. JAK inhibition reduces CD25 high CD27+ FOXp3+ T regulatory cells and causes a silencing of T effector cells in patients with myeloproliferative neoplasms whilst promoting a TH17 phenotype. Blood. 2013;122(21):4092.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
Kordasti, S.Y.1
Seidl, T.2
Abellan, P.P.3
-
26
-
-
84866158913
-
JAK inhibitors in psoriasis: A promising new treatment modality
-
Kwatra SG, Dabade TS, Gustafson CJ, Feldman SR. JAK inhibitors in psoriasis: a promising new treatment modality. J Drugs Dermatol. 2012;11(8):913-918.
-
(2012)
J Drugs Dermatol
, vol.11
, Issue.8
, pp. 913-918
-
-
Kwatra, S.G.1
Dabade, T.S.2
Gustafson, C.J.3
Feldman, S.R.4
-
27
-
-
84891365474
-
Jakpot! New small molecules in autoimmune and inflammatory diseases
-
Ghoreschi K, Gadina M. Jakpot! New small molecules in autoimmune and inflammatory diseases. Exp Dermatol. 2014;23(1):7-11.
-
(2014)
Exp Dermatol
, vol.23
, Issue.1
, pp. 7-11
-
-
Ghoreschi, K.1
Gadina, M.2
-
28
-
-
84908315856
-
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition
-
Xing L, Dai Z, Jabbari A, et al. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition. Nature Med. 2014;20(9):1043-1049.
-
(2014)
Nature Med
, vol.20
, Issue.9
, pp. 1043-1049
-
-
Xing, L.1
Dai, Z.2
Jabbari, A.3
-
29
-
-
84902581112
-
Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease
-
Spoerl S, Mathew NR, Bscheider M, et al. Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease. Blood. 2014;123(24):3832-3842.
-
(2014)
Blood
, vol.123
, Issue.24
, pp. 3832-3842
-
-
Spoerl, S.1
Mathew, N.R.2
Bscheider, M.3
-
30
-
-
84921891315
-
Ruxolitinib versus standard therapy for the treatment of polycythemia vera
-
Vannucchi AM, Kiladjian JJ, Griesshammer M, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372(5):426-435.
-
(2015)
N Engl J Med
, vol.372
, Issue.5
, pp. 426-435
-
-
Vannucchi, A.M.1
Kiladjian, J.J.2
Griesshammer, M.3
|