Extraction of perfluorinated alkyl acids from human serum for determination of the combined xenoestrogenic transactivity: A method development

Chemosphere

Volumn 129, Issue , 2015, Pages 232-238

  Bjerregaard Olesen, Christian ^a   Bossi, Rossana ^a   Bech, Bodil Hammer ^a   Bonefeld Jorgensen, Eva Cecilie ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Estrogen receptor; Perfluorinated compounds; Preparative normal phase HPLC; Solid phase extraction; Weak anion exchange; Xenoestrogenicity

Indexed keywords

CHEMICAL CONTAMINATION; CONSUMER PRODUCTS; ENDOCRINE DISRUPTERS; ENDOCRINOLOGY; HORMONES; PHASE SEPARATION; POTABLE WATER;

ANION EXCHANGE; ESTROGEN RECEPTOR; NORMAL PHASE HPLC; PERFLUORINATED COMPOUNDS; SOLID-PHASE EXTRACTION; XENOESTROGENICITY;

EXTRACTION;

ALKYL GROUP; ESTRADIOL; ESTROGEN RECEPTOR; ESTRONE; PERFLUORINATED ALKYL ACID; PERFLUORO COMPOUND; TESTOSTERONE; TETRAHYDROFURAN; UNCLASSIFIED DRUG; ENDOCRINE DISRUPTOR; FLUOROCARBON;

ENDOCRINE DISRUPTOR; EXCRETION; EXTRACTION METHOD; GENE EXPRESSION; HEALTH RISK; HORMONE; METABOLISM; POLLUTION EXPOSURE; SERUM;

ARTICLE; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; EXTRACTION; FEMALE; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE DETERMINATION; HUMAN; LIQUID LIQUID EXTRACTION; LUCIFERASE ASSAY; MALE; PREGNANT WOMAN; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TRANSACTIVATION; WEAK ANION EXCHANGE; XENOESTROGENIC TRANSACTIVITY; BLOOD; METABOLISM; PREGNANCY; PROCEDURES;

DENMARK;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDOCRINE DISRUPTORS; FEMALE; FLUOROCARBONS; HUMANS; MALE; PREGNANCY; RECEPTORS, ESTROGEN; SOLID PHASE EXTRACTION;

EID: 84926357285     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2014.08.071     Document Type: Article

References (23)

1. Benninghoff A.D., Bisson W.H., Koch D.C., Ehresman D.J., Kolluri S.K., Williams D.E. Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro. Toxicol. Sci. 2011, 120(1):42-58.
2. Bonefeld-Jorgensen E.C., Grunfeld H.T., Gjermandsen I.M. Effect of pesticides on estrogen receptor transactivation in vitro: a comparison of stable transfected MVLN and transient transfected MCF-7 cells. Mol. Cell. Endocrinol. 2005, 244(1-2):20-30.
3. Bonefeld-Jorgensen E.C., Hjelmborg P.S., Reinert T.S., Andersen B.S., Lesovoy V., Lindh C.H., Hagmar L., Giwercman A., Erlandsen M., Manicardi G.C., Spano M., Toft G., Bonde J.P. Xenoestrogenic activity in blood of European and Inuit populations. Environ. Health 2006, 5:12.
4. Bonefeld-Jorgensen E.C., Long M., Bossi R., Ayotte P., Asmund G., Kruger T., Ghisari M., Mulvad G., Kern P., Nzulumiki P., Dewailly E. Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study. Environ. Health 2011, 10:88.
5. Bonefeld-Jørgensen E.C., Long M., Fredslund S.O., Bossi R., Olsen J. Breast cancer risk after exposure to perfluorinated compounds in Danish Women: a case-control study nested in the Danish National Birth Cohort. Cancer Causes Control 2014, 10.1007/s10552-014-0446-7.
6. Bossi R., Riget F.F., Dietz R. Temporal and spatial trends of perfluorinated compounds in ringed seal (Phoca hispida) from Greenland. Environ. Sci. Technol. 2005, 39(19):7416-7422.
7. R.O. Burney, S.B. Mooney, L.C. Giudice (2008) Endocrinology of pregnancy, in: Endocrinology of Female Reproduction. <>. (Accessed 16.03.2012). http://www.endotext.org/female/female13/femaleframe13.htm.
8. Demirpence E., Duchesne M.J., Badia E., Gagne D., Pons M. MVLN cells: a bioluminescent MCE-7-derived cell line to study the modulation of estrogenic activity. J. Steroid Biochem. Mol. Biol. 1993, 46(3):355-364.
9. Fei C., McLaughlin J.K., Tarone R.E., Olsen J. Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort. Environ. Health Perspect. 2007, 115(11):1677-1682.
10. Fei C., McLaughlin J.K., Lipworth L., Olsen J. Maternal levels of perfluorinated chemicals and subfecundity. Hum. Reprod. 2009, 24(5):1200-1205.
11. Haug L.S., Huber S., Becher G., Thomsen C. Characterisation of human exposure pathways to perfluorinated compounds - comparing exposure estimates with biomarkers of exposure. Environ. Int. 2011, 37(4):687-693.
12. Hjelmborg P.S., Ghisari M., Bonefeld-Jorgensen E.C. SPE-HPLC purification of endocrine-disrupting compounds from human serum for assessment of xenoestrogenic activity. Anal. Bioanal. Chem. 2006, 385(5):875-887.
13. Kjeldsen L.S., Bonefeld-Jorgensen E.C. Perfluorinated compounds affect the function of sex hormone receptors. Environ. Sci. Pollut. Res. 2013, 20(11):8031-8044.
14. Kortenkamp A. Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals. Environ. Health Perspect. 2007, 115(Suppl. 1):98-105.
15. Kruger T., Long M., Ghisari M., Bonefeld-Jorgensen E.C. The combined effect of persistent organic pollutants in the serum POP mixture in Greenlandic Inuit: xenoestrogenic, xenoandrogenic and dioxin-like transactivities. Biomarkers 2012, 17(8):692-705.
16. Stockholm Convention, Listing of POPs in the Stockholm Convention. (2009) <>. (Accessed 24.07.2014). http://chm.pops.int/Convention/ThePOPs/ListingofPOPs/tabid/2509/Default.aspx.
17. Long M., Bossi R., Bonefeld-Jørgensen E.C. Level and temporal trend of perfluoroalkyl acids in Greenlandic Inuit. Int. J. Circumpolar Health 2012, 71. E1-E13.
18. Long M., Ghisari M., Bonefeld-Jorgensen E.C. Effects of perfluoroalkyl acids on the function of the thyroid hormone and the aryl hydrocarbon receptor. Environ. Sci. Pollut. Res. Int. 2013, 20(11):8045-8056.
19. Nilsson H., Karrman A., Westberg H., Rotander A., van Bavel B., Lindstrom G. A time trend study of significantly elevated perfluorocarboxylate levels in humans after using fluorinated ski wax. Environ. Sci. Technol. 2010, 44(6):2150-2155.
20. Olsen G.W., Burris J.M., Ehresman D.J., Froehlich J.W., Seacat A.M., Butenhoff J.L., Zobel L.R. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ. Health Perspect. 2007, 115(9):1298-1305.
21. Pons M., Gagne D., Nicolas J.C., Mehtali M. A new cellular model of response to estrogens: a bioluminescent test to characterize (anti) estrogen molecules. Biotechniques 1990, 9(4):450-459.
22. Posner S., Ross S., Poulsen P.B., Jörundsdottir H.Ó., Gunnlaugsdóttir H., Trier X., Jensen A.A., Katsogiannis A.A., Herzke D., Bonefeld-Jorgensen E.C., Jönsson C., Pedersen G.A., Ghisari M., Jensen S. Per- and polyfluorinated substances in the Nordic Countries - use, occurence and toxicology 2013, 542. TemaNord, Norden. 10.6027/TN2013-542.
23. Taniyasu S., Kannan K., So M.K., Gulkowska A., Sinclair E., Okazawa T., Yamashita N. Analysis of fluorotelomer alcohols, fluorotelomer acids, and short- and long-chain perfluorinated acids in water and biota. J. Chromatogr. A 2005, 1093(1-2):89-97.