DNA polymerase-mediated synthesis of unbiased Threose Nucleic Acid (TNA) polymers requires 7-deazaguanine to suppress G:G mispairing during TNA transcription

Journal of the American Chemical Society

Volumn 137, Issue 12, 2015, Pages 4014-4017

  Dunn, Matthew R ^a,c   Larsen, Andrew C ^c   Zahurancik, Walter J ^d   Fahmi, Nour Eddine ^c   Meyers, Madeline ^b,c   Suo, Zucai ^d   Chaput, John C ^b,c  

^a School of Life Sciences   (United States)

^b Department of Chemistry and Biochemistry ^*  (United States)

^c Arizona State University   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CHAINS; MOLECULES; NUCLEIC ACIDS; POLYMERS; SYNTHESIS (CHEMICAL); TRANSCRIPTION;

CHAIN TERMINATIONS; CHEMICAL SOLUTIONS; DARWINIAN EVOLUTION; ENZYME ACTIVE SITES; FUTURE APPLICATIONS; HIGH-EFFICIENCY; LIGAND BINDING ACTIVITY; PRE-STEADY STATE;

DNA;

DNA POLYMERASE; DOUBLE STRANDED DNA; NUCLEIC ACID; POLYMER; PRIMER DNA; SINGLE STRANDED DNA; THREOSE NUCLEIC ACID; UNCLASSIFIED DRUG; 7-DEAZAGUANINE; DNA DIRECTED DNA POLYMERASE; ERYTHROSE; GUANINE; TETROSE;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; DNA TEMPLATE; ENZYME ACTIVE SITE; HYDROGEN BOND; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION; STEADY STATE; SYNTHESIS; ANALOGS AND DERIVATIVES; ARCHAEON; BASE PAIRING; CHEMISTRY; ENZYMOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE;

ARCHAEA; BASE PAIRING; BASE SEQUENCE; DNA-DIRECTED DNA POLYMERASE; GUANINE; NUCLEIC ACIDS; TETROSES;

EID: 84926355512     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja511481n     Document Type: Article

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